8-Cyclopentadienyltricarbonyl 99mTc 8-Oxooctanoic Acid: A Novel Radiotracer for Evaluation of Medium Chain Fatty Acid Metabolism in the Liver

Bioconjugate Chemistry

Volumn 15, Issue 1, 2004, Pages 121-127

  Lee, Byung Chul ^a,b   Choe, Yearn Seong ^a   Chi, Dae Yoon ^b   Paik, Jin Young ^a   Lee, Kyung Han ^a   Choi, Yong ^a   Kim, Byung Tae ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Inha University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CHAINS; CHLORINE COMPOUNDS; CHROMIUM COMPOUNDS; FATTY ACIDS; METABOLISM; OXIDATION; RADIOACTIVE TRACERS; RADIOACTIVITY; SODIUM COMPOUNDS;

AQUEOUS EXTRACTION; BLOOD SAMPLES; FATTY ACID METABOLISM; FERROCENYL; HUMAN SERUM; IN-CONTROL; MEDIUM-CHAIN FATTY ACIDS; RADIOCHEMICAL YIELD; SYNTHESISED; TRANSFER REACTION;

RATS;

8 CYCLOPENTADIENYLTRICARBONYL 8 OXOOCTANOIC ACID TECHNETIUM TC 99M; CARBON TETRACHLORIDE; CHROMIUM CHLORIDE; CHROMIUM DERIVATIVE; CYCLOPENTADIENE DERIVATIVE; MEDIUM CHAIN FATTY ACID; METHYL 8 FERROCENYL 8 OXOOCTANOATE; OCTANOIC ACID DERIVATIVE; OXIDE; SODIUM; TECHNETIUM 99M; TRACER; UNCLASSIFIED DRUG; 8 CYCLOPENTADIENYLTRICARBONYLTECHNETIUM 8 OXOOCTANOIC ACID; 8-CYCLOPENTADIENYLTRICARBONYLTECHNETIUM-8-OXOOCTANOIC ACID; DIAGNOSTIC AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FATTY ACID; RADIOPHARMACEUTICAL AGENT; SOLVENT; TECHNETIUM COMPLEX;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; HYDROLYSIS; KIDNEY; LIVER CLEARANCE; LIVER METABOLISM; MALE; METABOLITE; MOUSE; NONHUMAN; RADIOACTIVITY; SERUM; SYNTHESIS; ANIMAL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG STABILITY; HUMAN; IMAGE PROCESSING; IN VITRO STUDY; INSTITUTE FOR CANCER RESEARCH MOUSE; INTOXICATION; LIVER; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SCINTISCANNING; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; CARBON TETRACHLORIDE POISONING; DRUG STABILITY; FATTY ACIDS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INDICATORS AND REAGENTS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; OCTANOIC ACIDS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0842285215     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0341268     Document Type: Article

References (25)

1. Burt, A. D., and James, O. F. W. (1994) Pathophysiology of the Liver. Pathology of the Liver (MacSween, R. N. M., Anthony, P. P., Scheuer, P. J., Burt, A. D., and Portmann, B. C., Eds.) pp 51-81, Churchill Livingstone, New York.
2. Zakim, D. (1996) Metabolism of Glucose and Fatty Acids by the Liver. Hepatology. A Textbook of Liver Disease (Zakim, D., and Boyer, T. D., Eds.) pp 58-92, Saunders, Philadelphia.
3. 11C]octanoate as a new radiopharmaceutical for assessing liver function using positron emission tomography. Nucl. Med. Biol. 25, 467-472.
4. 99m-labeled medium-chain fatty acid analogues metabolized by β-oxidation: radiopharmaceutical for assessing liver function. Bioconjugate Chem. 10, 489-495.
5. Bennett, M. J. (1994) The enzymes of mitochondrial fatty acid oxidation. Clin. Chim. Acta 226, 211-224.
6. Yamamura, N., Magata, Y., Konishi, J., and Saji, H. (1999) Evaluation of radioiodinated medium chain fatty acids as new diagnostic agents for the determination of hepatic viability. Eur. J. Nucl. Med. 26, 1597-1605.
7. Eckelman, W. C., Karesh, S. M., and Reba, R. C. (1975) New compounds: fatty acid and long chain hydrocarbon derivatives containing a strong chelating agent. J. Pharma. Sci. 64, 704-706.
8. Karesh, S. M., Eckelman, W. C., and Reba, R. C. (1977) Biological distribution of chemical analogues of fatty acids and long chain hydrocarbons containing a strong chelating agent. J. Pharm. Sci. 86, 225-228.
9. 99mTc-labeled fatty acid analogues for myocardial imaging. Nucl. Med. Biol. 18, 215-226.
10. 99mtechnetium fatty acid. Nucl. Med. Biol. 21, 117-123.
11. Loberg, M. D., Cooper, M., Harvey, E., Callery, P., and Faith, W. (1976) Development of new radiopharmaceuticals based on N-substituted iminodiacetic acid. J. Nucl. Med. 17, 633-638.
12. Ryan, J., Cooper, M., Loberg, M., Harvey, E., and Sikorski, S. (1977) Technetium-99m-labeled N-(2,6-dimethylphenyl-carbamoylmethyl) iminodiacetic acid (Tc-99m HIDA): a new radiopharmaceutcial for hepatobiliary imaging studies. J. Nucl. Med. 18, 997-1004.
13. Eisenhut, M. (1982) Simple labeling of omega-phenylfatty acids by iodine isotope exchange. Int. J. Appl. Radiat. Isot. 33, 499-504.
14. Ambrose, K. R., Owen, B. A., Goodman, M. M., and Knapp, F. F., Jr. (1987) Evaluation of the metabolism in rat hearts of two new radioiodinated 3-methyl-branched fatty acid myocardial imaging agents. Eur. J. Nucl. Med. 12, 486-491.
15. Schwochau, K. (1994) Technetium radiopharmaceuticals. Fundamentals, synthesis, structure, and development. Angew. Chem., Int. Ed. 33, 2258-2267.
16. Jurisson, S., Berning, D., Jia, W., and Ma, D. S. (1993) Coordination compounds in nuclear medicine. Chem. Rev. 93, 1137-1156.
17. Gholson, C. F., Provenza, J. M., and Bacon, B. R. (1990) Hepatological considerations in patients with parenchymal liver disease undergoing surgery. Am. J. Gastroenterol. 85, 487-496.
18. Spradau, T. W. and Katzenellenbogen, J. A. (1998) Preparation of cyclopentadienyltricarbonylrhenium complexes using a double ligand transfer reaction. Organometallics 17, 2009-2017.
19. Cesati, R. R., III, Tamagnan, G., Baldwin, R. H., Zoghbi, S. S., Innis, R. B., and Katzenellenbogen, J. A. (1999) Synthesis of cyclopentadienyl tricarbonyl technetium phenyl-tropane derivatives by direct double ligand transfer with ferrocene precursors. J. Labelled Compd. Radiopharm. 42, S150-152.
20. Skaddan, M. B., Wust, F. R., Jonson, S., Syhre, R., Welch, M. J., Spies, H., and Katzenellenbogen, J. A. (2000) Radiochemical synthesis and tissue distribution of Tc-99m-labeled 7α-substituted estradiol complex. Nucl. Med. Biol. 27, 269-278.
21. Hjelle, J. J., Grubbs, J. H., Beer, D. G., and Petersen, D. R. (1983) Time course of the carbon tetrachloride-induced decrease in mitochondrial aldehyde dehydrogenase activity. Toxicol. Appl. Pharmacol. 67, 159-165.
22. Forch, J., Less, M., and Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509.
23. Reeves, P. C. (1963) Carboxylation of Aromatic Compound: Ferrocenecarboxylic Acid. Organic Syntheses (Mrowca, J. J., Borecki, M. M., and Sheppard, W. A., Eds.) Coll. Vol. VI, pp 625-627, John Wiley & Sons, New York.
24. Burness, D. M. (1963) 3-Methyl-2-Furoic Acid and 3-Methylfuran. Organic Syntheses (Cason, J., and Hutchinson, R. B., Eds.) Coll. Vol. IV, pp 628-630, John Wiley & Sons, New York.
25. Hamilton, J. A. (1989) Medium-chain fatty acid binding to albumin and transfer to phospholipid bilayers. Proc. Natl. Acad. Sci. U.S.A. 86, 2663-2667.