Evaluation of [1-11C]Octanoate as a new radiopharmaceutical for assessing liver function using positron emission tomography

Nuclear Medicine and Biology

Volumn 25, Issue 5, 1998, Pages 467-472

  Yamamura, Norio ^a   Magata, Yasuhiro ^b   Kitano, Haruhiro ^b   Konishi, Junji ^b   Saji, Hideo ^a  

^a Grad Sch Pharmaceutical Sci   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Beta oxidation; Biodistribution; Fatty acid; Liver function; Metabolism; PET study

Indexed keywords

CARBON 11; CARBON TETRACHLORIDE; DRUG METABOLITE; OCTANOIC ACID C 11; OCTANOIC ACID DERIVATIVE; PALMITIC ACID; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; ASPARTATE AMINOTRANSFERASE; DIAGNOSTIC AGENT; OCTANOIC ACID; PALMITIC ACID DERIVATIVE;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG UPTAKE; FATTY ACID OXIDATION; HEPATITIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; ANIMAL; BIOTRANSFORMATION; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; ISOTOPE LABELING; LIVER; LIVER FUNCTION TEST; METHODOLOGY; RAT; SCINTISCANNING; SYNTHESIS; TISSUE DISTRIBUTION; WISTAR RAT;

ACETATES; ADULT; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOTRANSFORMATION; HUMANS; ISOTOPE LABELING; LIVER; LIVER FUNCTION TESTS; MALE; MICE; OCTANOIC ACIDS; PALMITATES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0032111547     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(98)00011-0     Document Type: Article

References (30)

1. Bennett M. J. The enzymes of mitochondrial fatty acid oxidation. Clin. Chim. Acta. 226:1994;211-224.
2. Forch J., Less M., Sloane-Stanley G. H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:1957;497-509.
3. Fraitz I. B. Factors influencing the rates of long-chain fatty acid oxidation and synthesis in mammalian systems. Physiol. Rev. 41:1961;51-129.
4. 18F] 2-deoxy-2-fluoro-D-glucose . J. Nucl. Med. 19:1978;1154-1161.
5. Gholson C. F., Provenza J. M., Bacon B. R. Hepatologic considerations in patients with parenchymal liver disease undergoing surgery. Am. J. Gastroenterol. 85:1990;487-496.
6. Goodman M. M., Kirsch G., Knapp F. F. Jr. Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids. J. Med. Chem. 27:1984;390-397.
7. Hjelle J. J., Grubbs J. H., Beer D. G., Petersen D. R. Time course of the carbon tetrachloride-induced decrease in mitochondrial aldehyde dehydrogenase activity. Toxicol. Appl. Pharmacol. 67:1983;159-165.
8. 11C]hexanoate as a PET tracer of fatty acid metabolism. Ann. Nucl. Med. 9:1995;51-57.
9. Kamiike W., Burdelski M., Steinhoff G., Ringe B., Lauchart W., Pichlmayr R. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation. Transplantation. 45:1988;138-143.
10. Karmen A. A note on the spectrophotometric assay of glutamic-oxalacetic transaminase in human blood. J. Clin. Invest. 34:1955;131-133.
11. Karmen A., Wroblerwski F., Ladue J. S. Transaminase activity in human blood. J. Clin. Invest. 34:1955;126-131.
12. Knapp F. F. Jr, Ambrose K. R., Goodman M. M. New radioiodinated methyl-branched fatty acids for cardiac studies. Eur. J. Nucl. Med. 12:1986;S39-S44.
13. Knapp F. F. Jr, Franken P., Kropp J. Cardiac SPECT with iodine-123-labeled fatty acids Evaluation of myocardial viability with BMIPP . J. Nucl. Med. 36:1995;1022-1030.
14. Kornberg A., Pricer W. E. J. Enzymatic esterification of α-glycerophosphate by long-chain fatty acids. J. Biol. Chem. 204:1953;345-357.
15. Kudo M., Todo A., Ikekubo K., Hino M., Ito H., Yamaguchi H., et al. Estimation of hepatic functional reserve by asialoglycoprotein receptor-binding, radiolabeled synthetic ligand Tc-99m-galactosyl-neoglycoalbumin - preclinical and clinical studies. Kaku Igaku. 24:1987;1653-1662.
16. 11C]octanoate in rats Pharmacokinetic basis for its application as a radiopharmaceutical for studying brain fatty acid metabolism . Ann. Nucl. Med. 9:1995;137-142.
17. Lanir A., Jenkins R. L., Caldwell C., Lee R. G., Khettry U., Clouse M. E. Hepatic transplantation survival Correlation with adenine nucleotide level in donor liver . Hepatology. 8:1988;471-475.
18. Liu W., Schob O., Pugmire J. E., Jackson D., Zucker K. A., Fry D. E., et al. Glycohydrolases as markers of hepatic ischemia-reperfusion injury and recovery. Hepatology. 24:1996;157-162.
19. Lossow W. J., Chaikoff I. L. Carbohydrate sparing of fatty acid oxidation. I: The relation of fatty acid chain length to the degree of sparing. II: The metabolism by which carbohydrate spares the oxidation of palmitic acid. Arch. Biochem. Biophys. 57:1955;23-40.
20. Martin D. B. Metabolism and energy Mechanisms. Frohlich E. D. Pathophysiology. 2nd edn. 1976;365-383 Lippincott, Philadelphia.
21. 18F-Labeled octanoates as potential agents for cerebral fatty acid studies The influence of 4-substitution and the fluorine position on biodistribution . Chem. Pharm. Bull. 43:1995;607-615.
22. 18F]Fluorooctanoic acid and its β-substituted derivatives as potential agents for cerebral fatty acid studies Synthesis and biodistribution . Nucl. Med. Biol. 21:1994;809-817.
23. Pochapsky S. S., VanBrocklin H. F., Welch M. J., Katzenellenbogen J. A. Synthesis and tissue distribution of fluorine-18-labeled trifluorohexadecanoic acids Considerations in the development of metabolically blocked myocardial imaging agents . Bioconjug. Chem. 1:1990;231-244.
24. Saha G. B., Go R. T., MacIntyre W. J. Radiopharmaceucticals for cardiovascular imaging. Int. J. Radiat. Appl. Instrum. B. 19:1992;1-20.
25. Schelbert H. R., Henze E., Schon H. R., Keen R., Hansen H., Selin C., et al. C-11 palmitate for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography III. In vivo demonstration of the effects of substrate availability on myocardial metabolism . Am. Heart J. 105:1983;492-504.
26. Schelbert H. R., Henze E., Keen R., Schon H. R., Hansen H., Selin C., et al. C-11 palmitate for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography IV. In vivo evaluation of acute demand-induced ischemia in dogs . Am. Heart J. 106:1983;736-750.
27. Seglen P. O. Preparation of rat liver cells: II. Effects of ions and chelators on tissue dispersion. Exp. Cell Res. 76:1973;25-30.
28. Seglen P. O. Preparation of isolated rat liver cells. Methods Cell Biol. 13:1976;29-83.
29. Sellevold O. F. M., Jynge P., Aarstad K. High-performance liquid chromatography A rapid isocratic method for determination of creatine compounds and adenine nucleotides in myocardial tissue . J. Mol. Cell. Cardiol. 18:1986;517-527.
30. Zakim D. Metabolism of glucose and fatty acids by the liver. Zakim D., Boyer T. D. Hepatology. 1982;76-109 Saunders, Philadelphia.