Functional characterization of an alternative [lactate dehydrogenase-like] malate dehydrogenase in Plasmodium falciparum

Parasitology Research

Volumn 92, Issue 1, 2004, Pages 43-47

  Chan, M ^a   Sim, T S ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

LACTATE DEHYDROGENASE; MALATE DEHYDROGENASE; PROTOZOAL PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

AFFINITY CHROMATOGRAPHY; ARTICLE; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PURIFICATION; ESCHERICHIA COLI; GENE IDENTIFICATION; GENETIC CODE; GENOME; MOLECULAR CLONING; MOLECULAR PHYLOGENY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OXIDATION; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; L-LACTATE DEHYDROGENASE; MALATE DEHYDROGENASE; MOLECULAR SEQUENCE DATA; NAD; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

ESCHERICHIA COLI; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0842265633     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-003-0996-1     Document Type: Article

References (12)

1. Bzik DJ, Fox BA, Gonyer K (1993) Expression of Plasmodium falciparum lactate dehydrogenase in Escherichia coli. Mol Biochem Parasitol 59:155-166
2. Certa U, Ghersa P, Dobeli H, Matile H, Kocher HP (1988) Aldolase activity of a Plasmodium falciparum protein with protective properties. Science 240:1036-1038
3. Chapman ADM, Cortes A, Dafforn TR, Clarke AR, Brady RL (1999) Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydroaenase, α-ketomalonate and tetrahydoNAD. J Mol Biol 285:703-712
4. Florens L, Washburn MP, Raine JD, Anthony RM, Graingerk M, Haynes JD, Moch JK, Muster N, Sacci JB, Tabb DL, Witney AA, Wolters D, Wu Y, Gardner MJ, Holderk AA, Sinden RE, Yates JR, Carucci DJ (2002) A proteomic view of the Plasmodium falciparum life cycle. Nature 419(3):520-526
5. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Huffman SL, Newbold C, Davis RW, Fraser CM, Barrell B (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419(6):498-511
6. Gietl C (1992) Malate dehydrogenase isoenzymes: cellular locations and role in the flow of metabolites between the cytoplasm and cell organelles. Biochim Biophys Acta 1100:217-34
7. Goward RC, Nicholls DJ (1994) Malate dehydrogenase: a model for structure, evolution and catalysis. Prot Sci 3:1883-1888
8. Hicks KE, Read M, Holloway SP, Sims PFG, Hyde JE (1991) Glycolytic pathway of the human malaria parasite Plasmodium falciparum: primary sequence analysis of the gene encoding 3-phosphoglycerate kinase and chromosomal mapping studies. Gene 100:123-129
9. Kaslow DC, Hill S (1990) Cloning metabolic pathway genes by complementation in Escherichia coli: isolation and expression of Plasmodium falciparum glucose phosphate isomerase. J Biol Chem 265:12337-12341
10. Lang-Unnasch N (1992) Purification and properties of Plasmodium falciparum malate dehydrogenase. Mol Biochem Parasitol 50:17-25
11. Madern D (2002) Molecular evolution within the L-malate and L-lactate dehydrogenase superfamily. J Mol Evol 54:825-840
12. Sim J, Chin HS, Wong E, Sim TS (in press) Conserved structural modules and bonding networks in isopenicillin N synthase related non-haem iron-dependent oxygenase and oxidases. J Mol Catal