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Volumn 50, Issue 2, 2004, Pages 355-364

[13C]Nandrolone Excretion in Trained Athletes: Interindividual Variability in Metabolism

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; NANDROLONE; 19 NORANDROSTERONE; 19-NORANDROSTERONE; CARBON; ESTRANE DERIVATIVE;

EID: 0742321921     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2003.022848     Document Type: Article
Times cited : (33)

References (47)
  • 1
    • 0002902148 scopus 로고    scopus 로고
    • Disorders of the testes and the male reproductive tract
    • Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Philadelphia: WB Saunders Co.
    • Griffin JE, Wilson JD. Disorders of the testes and the male reproductive tract. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Williams textbook of endocrinology, 9th ed. Philadelphia: WB Saunders Co., 1998:819-75.
    • (1998) Williams Textbook of Endocrinology, 9th Ed. , pp. 819-875
    • Griffin, J.E.1    Wilson, J.D.2
  • 2
    • 0035181618 scopus 로고    scopus 로고
    • Clinical review 138. Anabolic-androgenic steroid therapy in the treatment of chronic diseases
    • Basaria S, Wahlstrom JT, Dobs A. Clinical review 138. Anabolic-androgenic steroid therapy in the treatment of chronic diseases. J Clin Endocrinol Metab 2001;86:5108-17.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5108-5117
    • Basaria, S.1    Wahlstrom, J.T.2    Dobs, A.3
  • 4
    • 0012734960 scopus 로고    scopus 로고
    • Historique et évolution du dopage
    • De Mondenard JP. Historique et évolution du dopage. Ann Toxicol Anal 2000;XII:5-18.
    • (2000) Ann Toxicol Anal , vol.12 , pp. 5-18
    • De Mondenard, J.P.1
  • 7
    • 0032985748 scopus 로고    scopus 로고
    • Steroids and steroid-like compounds
    • Blue JG, Lombardo JA. Steroids and steroid-like compounds. Clin Sports Med 1999;18:667-89.
    • (1999) Clin Sports Med , vol.18 , pp. 667-689
    • Blue, J.G.1    Lombardo, J.A.2
  • 8
    • 0004082043 scopus 로고    scopus 로고
    • The pathology of drug abuse
    • Karsh SB, ed. Boca Raton, FL: CRC Press
    • Karsh SB. The pathology of drug abuse. In: Karsh SB, ed. Anabolic steroids, 2nd ed. Boca Raton, FL: CRC Press, 1996:409-29.
    • (1996) Anabolic Steroids, 2nd Ed. , pp. 409-429
    • Karsh, S.B.1
  • 9
    • 0000805777 scopus 로고
    • Urinary metabolites of administered 19-nortestosterone
    • Engel LL, Alexander J, Wheeler M. Urinary metabolites of administered 19-nortestosterone. J Biol Chem 1958;231:159-64.
    • (1958) J Biol Chem , vol.231 , pp. 159-164
    • Engel, L.L.1    Alexander, J.2    Wheeler, M.3
  • 10
    • 0021895045 scopus 로고
    • Gas chromatographic/ mass spectrometric analysis of 19-nortestosterone urinary metabolites in man
    • Massé R, Laliberté C, Tremblay L, Dugal R. Gas chromatographic/ mass spectrometric analysis of 19-nortestosterone urinary metabolites in man. Biomed Mass Spectrom 1985;12:2405-8.
    • (1985) Biomed Mass Spectrom , vol.12 , pp. 2405-2408
    • Massé, R.1    Laliberté, C.2    Tremblay, L.3    Dugal, R.4
  • 11
    • 0742324225 scopus 로고    scopus 로고
    • Prohibited classes of substances and prohibited methods
    • Lausanne, Switzerland: Olympic International Committee
    • Olympic International Committee (IOC). Prohibited classes of substances and prohibited methods. In: Olympic movement antidoping code, appendix A. Lausanne, Switzerland: Olympic International Committee, 1999:95pp.
    • (1999) Olympic Movement Antidoping Code, Appendix A
  • 13
    • 0033067610 scopus 로고    scopus 로고
    • Urinary excretion of 19-norandrosterone of endogenous origin in man: Quantitative analysis by chromatography-mass spectrometry
    • Dehennin L, Bonnaire Y, Plou P. Urinary excretion of 19-norandrosterone of endogenous origin in man: quantitative analysis by chromatography-mass spectrometry. J Chromatogr B Biomed Appl 1999;721:301-7.
    • (1999) J Chromatogr B Biomed Appl , vol.721 , pp. 301-307
    • Dehennin, L.1    Bonnaire, Y.2    Plou, P.3
  • 14
    • 0001614087 scopus 로고    scopus 로고
    • Détermination des concentrations physiologiques de la norandrosterone et de la norétiocholanolone, métabolites urinaires de la nandrolone par CPG/SM
    • Jeanneau T, Kintz P, Cirimele V, Ludes B. Détermination des concentrations physiologiques de la norandrosterone et de la norétiocholanolone, métabolites urinaires de la nandrolone par CPG/SM. Toxicorama 1999;XI:25-9.
    • (1999) Toxicorama , vol.11 , pp. 25-29
    • Jeanneau, T.1    Kintz, P.2    Cirimele, V.3    Ludes, B.4
  • 15
    • 0032617422 scopus 로고    scopus 로고
    • Norandrosterone et norétiocholanolone: Les metabolites révélateurs
    • Kintz P, Cirimele V, Ludes B. Norandrosterone et noré tiocholanolone: les metabolites révélateurs. Acta Clin Belg Suppl 1999; 1:68-73.
    • (1999) Acta Clin Belg Suppl , vol.1 , pp. 68-73
    • Kintz, P.1    Cirimele, V.2    Ludes, B.3
  • 16
    • 0033052774 scopus 로고    scopus 로고
    • Evidence for the presence of endogenous 19-norandrosterone in human urine
    • Le Bizec B, Monteau F, Gaudin I, André F. Evidence for the presence of endogenous 19-norandrosterone in human urine. J Chromatogr B Biomed Appl 1999;723:157-72.
    • (1999) J Chromatogr B Biomed Appl , vol.723 , pp. 157-172
    • Le Bizec, B.1    Monteau, F.2    Gaudin, I.3    André, F.4
  • 17
    • 0742324222 scopus 로고    scopus 로고
    • Détermination des concentrations physiologiques de la norandrosterone et de la norétiocholanolone, métabolites urinaires de la nandrolone par CPG/SM. Résultats d'une étude multicentrique
    • Humbert L, L'Hermite M, Vayssette F, Pépin G, Descamps F, Ghysel MH, et al. Détermination des concentrations physiologiques de la norandrosterone et de la norétiocholanolone, métabolites urinaires de la nandrolone par CPG/SM. Résultats d'une étude multicentrique. Annal Toxicol Anal 2000;XII:36-42.
    • (2000) Annal Toxicol Anal , vol.12 , pp. 36-42
    • Humbert, L.1    L'Hermite, M.2    Vayssette, F.3    Pépin, G.4    Descamps, F.5    Ghysel, M.H.6
  • 18
    • 0035162065 scopus 로고    scopus 로고
    • Endogenous origin of norandrosterone in female urine: Indirect evidence for the production of 19-norsteroids as by-products in the conversion from androgen to estrogen
    • Van Eenoo P, Delbeke FT, De Jong FH, De Backer P. Endogenous origin of norandrosterone in female urine: indirect evidence for the production of 19-norsteroids as by-products in the conversion from androgen to estrogen. J Steroids Biochem Mol Biol 2001; 78:351-7.
    • (2001) J Steroids Biochem Mol Biol , vol.78 , pp. 351-357
    • Van Eenoo, P.1    Delbeke, F.T.2    De Jong, F.H.3    De Backer, P.4
  • 19
    • 0002287421 scopus 로고    scopus 로고
    • Nandrolone metabolites in football players: Utility for in and out of competition tests
    • Schànzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Köln, Germany: Sport and Buch Strauss
    • Saugy M, Robinson N, Cardis C, Shweizer C, Rivier L, Mangin P, et al. Nandrolone metabolites in football players: utility for in and out of competition tests. In: Schànzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Recent advances in doping analysis (17th Cologne Workshop on Dope Analysis). Köln, Germany: Sport and Buch Strauss, 2000:95-108.
    • (2000) Recent Advances in Doping Analysis (17th Cologne Workshop on Dope Analysis) , pp. 95-108
    • Saugy, M.1    Robinson, N.2    Cardis, C.3    Shweizer, C.4    Rivier, L.5    Mangin, P.6
  • 20
    • 0035500916 scopus 로고    scopus 로고
    • Detection of nandrolone metabolites in urine after a football game in professional and amateur players: A Bayesian comparison
    • Robinson N, Taroni F, Saugy M, Ayotte C, Mangin P, Dvorak J. Detection of nandrolone metabolites in urine after a football game in professional and amateur players: a Bayesian comparison. Forensic Sci Int 2001;122:130-5.
    • (2001) Forensic Sci Int , vol.122 , pp. 130-135
    • Robinson, N.1    Taroni, F.2    Saugy, M.3    Ayotte, C.4    Mangin, P.5    Dvorak, J.6
  • 22
    • 0002525224 scopus 로고    scopus 로고
    • Nutritional supplements and doping controls. IAAF new studies in athletics
    • Ayotte C. Nutritional supplements and doping controls. IAAF new studies in athletics. Aachen, Germany: Meyer & Meyer Sport 1999;14:37-42.
    • (1999) Aachen, Germany: Meyer & Meyer Sport , vol.14 , pp. 37-42
    • Ayotte, C.1
  • 23
    • 0033750530 scopus 로고    scopus 로고
    • Trace contamination of over-the-counter androstenedione and positive urine test result for a nandrolone metabolite
    • Catlin DH, Leder BZ, Ahrens B, Starcevic B, Hatton CK, Green GA, et al. Trace contamination of over-the-counter androstenedione and positive urine test result for a nandrolone metabolite. JAMA 2000;284:2618-21.
    • (2000) JAMA , vol.284 , pp. 2618-2621
    • Catlin, D.H.1    Leder, B.Z.2    Ahrens, B.3    Starcevic, B.4    Hatton, C.K.5    Green, G.A.6
  • 25
    • 1542455212 scopus 로고    scopus 로고
    • The analysis of "non-hormonal" nutritional supplements for prohormones
    • Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Köln, Germany: Sport and Buch Strauss
    • Geyer H, Mareck-Engelke U, Wagner A, Schänzer W. The analysis of "non-hormonal" nutritional supplements for prohormones. In: Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Recent advances in doping analysis (19th Cologne Workshop on Dope Analysis). Köln, Germany: Sport and Buch Strauss, 2001: 63-71.
    • (2001) Recent Advances in Doping Analysis (19th Cologne Workshop on Dope Analysis) , pp. 63-71
    • Geyer, H.1    Mareck-Engelke, U.2    Wagner, A.3    Schänzer, W.4
  • 26
    • 0036301062 scopus 로고    scopus 로고
    • Nutritional supplements and doping
    • Pipe A, Ayotte C. Nutritional supplements and doping. Clin J Sports Med 2002;12:245-9.
    • (2002) Clin J Sports Med , vol.12 , pp. 245-249
    • Pipe, A.1    Ayotte, C.2
  • 28
    • 0028410574 scopus 로고
    • Gas chromatography/combustion/isotope-ratio mass spectrometry analysis of urinary steroids to detect misuse of testosterone in sport
    • Becchi M, Aguilera R, Farizon Y, Flament MM. Casabianca H, James P. Gas chromatography/combustion/isotope-ratio mass spectrometry analysis of urinary steroids to detect misuse of testosterone in sport. Rapid Commun Mass Spectrom 1994;8: 304-8.
    • (1994) Rapid Commun Mass Spectrom , vol.8 , pp. 304-308
    • Becchi, M.1    Aguilera, R.2    Farizon, Y.3    Flament, M.M.4    Casabianca, H.5    James, P.6
  • 29
    • 0030022083 scopus 로고    scopus 로고
    • Improved method of detection of testosterone abuse by gas chromatography/combustion/isotope ratio mass spectrometry analysis of urinary steroids
    • Aguilera R, Becchi M, Casabianca H, Hatton CK, Catlin DH, Starcevic B, et al. Improved method of detection of testosterone abuse by gas chromatography/combustion/isotope ratio mass spectrometry analysis of urinary steroids. J Mass Spectrom 1996;31:169-76.
    • (1996) J Mass Spectrom , vol.31 , pp. 169-176
    • Aguilera, R.1    Becchi, M.2    Casabianca, H.3    Hatton, C.K.4    Catlin, D.H.5    Starcevic, B.6
  • 31
    • 0030934910 scopus 로고    scopus 로고
    • Confirming testosterone administration by isotope ratio mass spectrometry analysis of urinary androstanediols
    • Shackleton CHL, Phillips A, Chang T, Li Y. Confirming testosterone administration by isotope ratio mass spectrometry analysis of urinary androstanediols. Steroids 1997;62:379-87.
    • (1997) Steroids , vol.62 , pp. 379-387
    • Shackleton, C.H.L.1    Phillips, A.2    Chang, T.3    Li, Y.4
  • 33
    • 0032949912 scopus 로고    scopus 로고
    • Screening urine for exogenous testosterone by isotope ratio mass spectrometry analysis of one pregnanediol and two androstanediols
    • Aguilera R, Catlin DH, Becchi M, Phillips A, Wang C, Swerdloff RS, et al. Screening urine for exogenous testosterone by isotope ratio mass spectrometry analysis of one pregnanediol and two androstanediols. J Chromatogr B Biomed Appl 1999;727:95-105.
    • (1999) J Chromatogr B Biomed Appl , vol.727 , pp. 95-105
    • Aguilera, R.1    Catlin, D.H.2    Becchi, M.3    Phillips, A.4    Wang, C.5    Swerdloff, R.S.6
  • 34
    • 0035136380 scopus 로고    scopus 로고
    • Performance characteristics of a carbon isotope ratio method for detecting doping with testosterone based on urine diols: Controls and athletes with elevated testosterone/epitestosterone ratios
    • Aguilera R, Chapman TE, Starcevic B, Hatton CK, Catlin DH. Performance characteristics of a carbon isotope ratio method for detecting doping with testosterone based on urine diols: controls and athletes with elevated testosterone/epitestosterone ratios. Clin Chem 2001;47:292-300.
    • (2001) Clin Chem , vol.47 , pp. 292-300
    • Aguilera, R.1    Chapman, T.E.2    Starcevic, B.3    Hatton, C.K.4    Catlin, D.H.5
  • 36
    • 3042851569 scopus 로고    scopus 로고
    • Differentiation of endogenous and exogenous steroids in urine by means of isotope mass spectrometry
    • Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Köln, Germany: Sport and Buch Strauss
    • Ueki M, Takato Y, Okano M, Ikekita A, Sato M. Differentiation of endogenous and exogenous steroids in urine by means of isotope mass spectrometry. In: Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Recent advances in doping analysis (19th Cologne Workshop on Dope Analysis). Köln, Germany: Sport and Buch Strauss, 2001:145-54.
    • (2001) Recent Advances in Doping Analysis (19th Cologne Workshop on Dope Analysis) , pp. 145-154
    • Ueki, M.1    Takato, Y.2    Okano, M.3    Ikekita, A.4    Sato, M.5
  • 38
    • 0024602910 scopus 로고
    • Integrated methodological approach to the gas chromatographic-mass spectrometric analysis of anabolic steroid metabolites in urine
    • Massé R, Ayotte C, Dugal R. Integrated methodological approach to the gas chromatographic-mass spectrometric analysis of anabolic steroid metabolites in urine. J Chromatogr 1989;489:23-50.
    • (1989) J Chromatogr , vol.489 , pp. 23-50
    • Massé, R.1    Ayotte, C.2    Dugal, R.3
  • 39
    • 0025234923 scopus 로고
    • Analysis of anabolic steroids using GC/MS with selected ion monitoring
    • Chung B, Choo H-Y, Kim T, Eom K, Kwon O, Suh J, et al. Analysis of anabolic steroids using GC/MS with selected ion monitoring. J Anal Toxicol 1990;14:91-5.
    • (1990) J Anal Toxicol , vol.14 , pp. 91-95
    • Chung, B.1    Choo, H.-Y.2    Kim, T.3    Eom, K.4    Kwon, O.5    Suh, J.6
  • 40
    • 0027415714 scopus 로고
    • Metabolism of anabolic steroids in man: Synthesis and use of reference substances for identification of anabolic steroid metabolites
    • Schänzer W, Donike M. Metabolism of anabolic steroids in man: synthesis and use of reference substances for identification of anabolic steroid metabolites. Anal Chim Acta 1993;275:23-48.
    • (1993) Anal Chim Acta , vol.275 , pp. 23-48
    • Schänzer, W.1    Donike, M.2
  • 41
    • 0002963137 scopus 로고
    • Simple purification of urine samples for improved detection of anabolic and endogenous steroids
    • Douike M, Geyer H, Gotzmann A, Mareck-Engelke U, Rauth S, eds. Köln, Germany: Sport and Buch Strauss
    • Geyer H, Mareck-Engelke U, Schänzer W, Donike M. Simple purification of urine samples for improved detection of anabolic and endogenous steroids. In: Douike M, Geyer H, Gotzmann A, Mareck-Engelke U, Rauth S, eds. Recent advances in doping analysis (11th Cologne Workshop on Dope Analysis). Köln, Germany: Sport and Buch Strauss, 1994:97-103.
    • (1994) Recent Advances in Doping Analysis (11th Cologne Workshop on Dope Analysis) , pp. 97-103
    • Geyer, H.1    Mareck-Engelke, U.2    Schänzer, W.3    Donike, M.4
  • 42
    • 0030573012 scopus 로고    scopus 로고
    • Testing for natural and synthetic anabolic agents in human urine
    • Ayotte C, Goudreault D, Charlebois A. Testing for natural and synthetic anabolic agents in human urine. J Chromatogr B 1996; 687:3-25.
    • (1996) J Chromatogr B , vol.687 , pp. 3-25
    • Ayotte, C.1    Goudreault, D.2    Charlebois, A.3
  • 43
    • 4243272420 scopus 로고    scopus 로고
    • Metabolism of nortestosterone, norandrostenedione and norandrostenediol. Identification of 3α-hydroxyestr-4-en-17-one glucuronide and 3α,16α-dihydroxy-5α-estran-17-one glucuronide and sulphate
    • Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Köln, Germany: Sport and Buch Strauss
    • Schänzer W, Breidbach A, Geyer H, Van Kuk C, Nolteernsting E, Thevis M. Metabolism of nortestosterone, norandrostenedione and norandrostenediol. Identification of 3α-hydroxyestr-4-en-17-one glucuronide and 3α,16α-dihydroxy-5α-estran-17-one glucuronide and sulphate. In: Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Recent advances in doping analysis (18th Cologne Workshop on Dope Analysis). Köln, Germany: Sport and Buch Strauss, 2000:155-74.
    • (2000) Recent Advances in Doping Analysis (18th Cologne Workshop on Dope Analysis) , pp. 155-174
    • Schänzer, W.1    Breidbach, A.2    Geyer, H.3    Van Kuk, C.4    Nolteernsting, E.5    Thevis, M.6
  • 44
    • 0032820682 scopus 로고    scopus 로고
    • Over-the-counter anabolic steroids 4-androstene-3,17-dione; 4-androstene-3α,17α-diol, and 19-nor-androstene-3,17-dione: Excretion studies in men
    • Uralets VP, Gillette PA. Over-the-counter anabolic steroids 4-androstene-3,17-dione; 4-androstene-3α,17α-diol, and 19-nor-androstene-3,17-dione: excretion studies in men. J Anal Toxicol 1999;23:357-66.
    • (1999) J Anal Toxicol , vol.23 , pp. 357-366
    • Uralets, V.P.1    Gillette, P.A.2
  • 45
    • 0033625001 scopus 로고    scopus 로고
    • Over-the-counter Δ5 anabolic steroids 5-androstene-3,17-dione; 5-androstene-3β,17β-diol; dehydroepiandrosterone and 19-nor-5-androstene-3,17-dione: Excretion studies in men
    • Uralets VP, Gillette PA. Over-the-counter Δ5 anabolic steroids 5-androstene-3,17-dione; 5-androstene-3β,17β-diol; dehydroepiandrosterone and 19-nor-5-androstene-3,17-dione: excretion studies in men. J Anal Toxicol 2000;24:188-93.
    • (2000) J Anal Toxicol , vol.24 , pp. 188-193
    • Uralets, V.P.1    Gillette, P.A.2
  • 46
    • 0035143691 scopus 로고    scopus 로고
    • Adjustment to concentration-dilution of spot urine samples: Correlation between specific gravity and creatinine
    • Carrieri M, Trevisan A, Bartolucci GB. Adjustment to concentration- dilution of spot urine samples: correlation between specific gravity and creatinine. Int Arch Occup Environ Health 2001;74:63-7.
    • (2001) Int Arch Occup Environ Health , vol.74 , pp. 63-67
    • Carrieri, M.1    Trevisan, A.2    Bartolucci, G.B.3


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