High-risk AML complicated by pulmonary aspergillosis: Successful treatment with nonmyeloablative stem cell transplantation and long-term administration of voriconazole

Annals of Hematology

Volumn 83, Issue 2, 2004, Pages 133-136

  Eibl, Margit ^a   Auner, H W ^a   Zinke Cerwenka, W ^a   Sill, H ^a   Dornbusch, H J ^a   Linkesch, W ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Aaspergillosis; AML; Diabetes insipidus; Nonmyeloablative stem cell transplantation; Viroconazole

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; ANTIBIOTIC AGENT; ATG FRESENIUS S; CALCIUM CHANNEL BLOCKING AGENT; CASPOFUNGIN; CYCLOSPORIN A; CYTARABINE; CYTOSTATIC AGENT; DESMOPRESSIN; FLUCONAZOLE; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IDARUBICIN; ITRACONAZOLE; MITOXANTRONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THYMOCYTE ANTIBODY; VORICONAZOLE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CANCER REGRESSION; CASE REPORT; CHROMOSOME ABERRATION; CHROMOSOME INVERSION 9; DIABETES INSIPIDUS; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEBRILE NEUTROPENIA; FEMALE; GRAFT VERSUS HOST REACTION; HIGH RISK PATIENT; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; LONG TERM CARE; LUNG ASPERGILLOSIS; MONOSOMY 7; MYCOSIS; NEUTROPENIA; PANCYTOPENIA; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROGNOSIS; RECURRENT DISEASE; SYMPTOMATOLOGY; TREATMENT OUTCOME;

ADULT; ANTIFUNGAL AGENTS; ASPERGILLOSIS; FEMALE; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; LUNG DISEASES, FUNGAL; MYELOABLATIVE AGONISTS; PYRIMIDINES; RADIOGRAPHY, THORACIC; STEM CELL TRANSPLANTATION; TOMOGRAPHY, X-RAY COMPUTED; TRANSPLANTATION CONDITIONING; TRIAZOLES;

EID: 0742306798     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-003-0782-2     Document Type: Article

References (13)

1. Aliff TB, Maslak PG, Jurcic JG, Heaney ML, Cathcart KN, Sepkowitz KA, Weiss MA (2003) Refractory aspergillus pneumonia in patients with acute leukemia: successful therapy with combination caspofungin and liposomal amphotericin. Cancer 97:1025-1032
2. Castagnola C, Morra E, Bernasconi P, Astori C, Santagostino A, Bernasconi C (1995) Acute myeloid leukemia and diabetes insipidus: results in 5 patients. Acta Haematol 93:1-4
3. Denning DW, Ribaud P, Milpied N, Caillot D, Herbrecht R, Thiel E, Haas A, Ruhnke M, Lode H (2002) Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis. Clin Infect Dis 34:563-571
4. Herbrecht R, Denning DW, Patterson DF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard JR, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, De Pauw B (2002) Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347:408-415
5. Hermann S, Klein SA, Jacobi V, Thalhammer A, Bialleck H, Duchscherer M, Wassmann B, Hoelzer D, Martin H (2001) Older patients with high-risk fungal infections can be successfully allografted using non-myeloablative conditioning in combination with intensified supportive care regimens. Br J Haematol 113:446-454
6. Junghanss C, Marr KA, Carter RA, Sandmaier BM, Maris MB, Maloney DG, Chauncey T, McSweeney PA, Storb R (2002) Incidence and outcome of bacterial and fungal infections following nonmycloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: a matched control study. Biol Blood Marrow Transplant 8:512-520
7. Lavabre-Bertrand T, Bourquard P, Chiesa J, Berthéas MF, Lefort G, Taib J, Lavabre-Bertrand C, Navarro M, Bureau JP (2001) Diabetes insipidus revealing acute myelogenous leukaemia with high platelet count, monosomy 7 and abnormalities of chromosome 3: a new entity? Eur J Haematol 66:66-69
8. Lin SJ, Schranz J, Teutsch SM (2001) Aspergillosis case-fatality rate: systematic review of the literature. Clin Infect Dis 32:358-366
9. Mattei D, Mordini N, Lo Nigro C, Ghirardo D, Ferrua MT, Osenda M, Gallamini A, Bacigalupo A, Viscoli C (2002) Voriconazole in the management of invasive aspergillosis in two patients with acute myeloid leukemia undergoing stem cell transplantation. Bone Marrow Transplant 30:967-970
10. Müller CI, Engelhardt M, Laubenberger J, Kunzmann R, Engelhardt R, Lübbert M (2002) Myelodysplastic syndrome in transformation to acute myeloid leukemia presenting with diabetes insipidus: due to pituitary infiltration association with abnormalities of chromosome 3 and 7. Eur J Haematol 69:115-119
11. Platzbecker U, Thiede C, Freiberg-Richter J, Helwig A, Schäkel U, Mohr B, Schaich M, Elminger G, Bornhäuser M (2001) Early allogeneic blood stem cell transplantation after modified conditioning therapy during marrow aplasia: stable remission in high risk acute myeloid leukemia. Bone Marrow Transplant 27:543-546
12. Rubin MA, Carroll KC, Cahill BC (2002) Caspofungin in combination with itraconazole for the treatment of invasive aspergillosis in humans. Clin Infect Dis 34:1160-1161
13. Xun CQ, McSweeney PA, Boeckh M, Storb R (1999) Successful nonmyeloablative allogeneic hematopoietic stem cell transplantat in an acute leukemia patient with chemotherapy-induced marrow aplasia and progressive pulmonary aspergillosis. Blood 94:3273-3276