Localization of Inhibins and Activins in Normal Endocrine Cells and Endocrine Tumors of the Gut and Pancreas: An Immunohistochemical and in Situ Hybridization Study

Journal of Histochemistry and Cytochemistry

Volumn 52, Issue 2, 2004, Pages 217-225

  La Rosa, Stefano ^a   Uccella, Silvia ^b   Marchet, Silvia ^b   Capella, Carlo ^a,b   Lloyd, Ricardo V ^c  

^a OSPEDALE DI CIRCOLO   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

^c MAYO CLINIC   (United States)

Author keywords

Activin; Endocrine tumor; Gut; Immunohistochemistry; In situ hybridization; Inhibin; Localization; Pancreas

Indexed keywords

ACTIVIN; ACTIVIN A; FOLLISTATIN; GROWTH FACTOR; INHIBIN A; INHIBIN B; MESSENGER RNA; MYELOPID; PROTEIN SUBUNIT;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL FUNCTION; ENDOCRINE CELL; ENDOCRINE TUMOR; FEMALE; GASTRIN CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SOMATOSTATIN CELL;

EID: 0742287917     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540405200210     Document Type: Article

References (52)

1. Akhurst RJ, Lehnert SA, Gatherer D, Duffie E (1990) The role of THFβ in mouse development. Ann NY Acad Sci 593:259-271
2. Benhamed M, Morera AM, Ghiglieri C, Tabone E, Menezo Y, Hendrick JC, Franchimont P (1993) Transforming growth factor-β in the ovary. Ann NY Acad Sci 687:13-19
3. Bilezikjian LM, Vale WW (1992) Local extragonadal roles of activins. Trends Endocrinol Metab 3:218-223
4. Bordi C, D'Adda T, Azzoni C, Canavese G, Brandi ML (1998) Gastrointestinal endocrine tumors: recent developments. Endocrine Pathol 9:99-115
5. Bordi C, Falchetti A, Buffa R, Azzoni C, D'Adda T, Caruana P, Rindi G, et al. (1994) Production of basic fibroblast growth factor by gastric carcinoid tumors and their putative cell of origin. Hum Pathol 25:175-180
6. Creutzfeldt W, Ebert R (1985) New development in the incretin concept. Diabetologia 28:565-573
7. DePaolo LV, Bicsak TA, Erickson GF, Shimasaki S, Ling N (1991) Follistatin and activin: a potential intrinsic regulatory system within diverse tissues. Proc Soc Exp Biol Med 198:500-512
8. Duprè J, Ross SA, Watson D, Brown JC (1973) Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 37:826-828
9. Elhai D, Andersen DK, Brown JC (1979) Pancreatic α- and β-cell responses to GIP infusion in normal man. Am J Physiol 237: E185-191
10. Florio P, Luisi S, Marchetti P, Lupi R, Cobellis L, Falaschi C, Sugino H, et al. (2000) Activin A stimulates insulin secretion in cultured human pancreatic islets. J Endocrinol Invest 23:231-234
11. Furukawa M, Eto Y, Kojima I (1995) Expression of immunoreactive activin A in fetal rat pancreas. Endocrine J 42:63-68
12. Halvorson LM, DeCherney AH (1996) Inhibin, activin, and follistatin in reproductive medicine. Fertil Steril 65:459-469
13. Hsueh AJ, Dahl KD, Vaughan J, Tucker E, Rivier J, Bardin CW, Vale W (1987) Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc Natl Acad Sci USA 84:5082-5086
14. Jakowlew SB, Ciment G, Tuan RS, Sporn MB, Roberts AB (1994) Expression of transforming growth factor-β2 and β3 mRNAs and proteins in the developing chicken embryo. Differentiation 55:105-118
15. Kleeff J, Ishiwata T, Friess H, Büchler MW, Korc M (1998) Concomitant over-expression of activin/inhibin β subunits and their receptors in human pancreatic cancer. Int J Cancer 77:860-868
16. Kuroda M, Oka T, Oka Y, Yamoki T, Ohtsubo K, Mori S, Watanabe T, et al. (1995) Colocalization of vascular endothelial growth factor (vascular permeability factor) and insulin in pancreatic islet cells. J Clin Endocrinol Metab 80:3196-3200
17. Lan HY, Mu W, Nikolic-Paterson DJ, Atkins RC (1995) A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem 43:97-102
18. La Rosa S, Capella C, Lloyd RV (2002) Localization of myosin XVA in endocrine tumors of gut and pancreas. Endocrine Pathol 13:29-37
19. La Rosa S, Uccella S, Billo P, Facco C, Sessa F, Capella C (1999) Immunohistochemical localization of α- and βA-subunits of inhibin/activin in human normal endocrine cells and related tumors of the digestive system. Virchows Arch 434:29-36
20. La Rosa S, Uccella S, Capella C, Chiaravalli AM, Sessa F (1998) Localization of acidic fibroblast growth factor, fibroblast growth factor receptor-4, transforming growth factor-α, and epidermal growth factor receptor in human endocrine cells of the gut and related tumors: an immunohistochemical study. Appl Immunohistochem; 6:199-208
21. La Rosa S, Uccella S, Erba S, Capella C, Sessa F (2001) Immunohistochemical detection of fibroblast growth factor receptors in normal endocrine cells and related tumors of the digestive system. Appl Immunohistochem Mol Morphol 9:319-328
22. La Rosa S, Uccella S, Finzi G, Albarello L, Sessa F, Capella C (2003) Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features. Hum Pathol 34:18-27
23. Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R (1986) Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin. Nature 321:779-782
24. Lloyd RV, Vidal S, Jin L, Zhang S, Kovacs K, Horvath E, Scheithauer BW, et al. (2001) Myosin XVA expression in the pituitary and in other neuroendocrine tissues and tumors. Am J Pathol 159:1375-1382
25. Mason DY, Abdulaziz B, Falini H, Stein H (1983) Double immunoenzymatic labelling. In Polak JM, Van Noorden S, ed. Immunocytochemistry. Practical Applications in Pathology and Biology. Bristol, Wright, 113-128
26. Mason J, Niall HD, Seeburg DH (1986) Structure of two human ovarian inhibins. Biochem Biophys Res Commun 135:957-964
27. Massagué J (1987) The TGFβ family of growth and differentiation factors. Cell 49:437-438
28. Mather JP, Woodruff TK, Krummen LA (1992) Paracrine regulation of reproductive function by inhibin and activin. Proc Soc Exp Biol Med 20:1-15
29. Mathews LS (1994) Activin receptors and cellular signaling by the receptor serine kinase family. Endocrine Rev 15:310-325
30. Meunier H, Rivier C, Evans RM, Vale W (1988) Gonadal and extragonadal expression of inhibin α, βA and βB subunits in various tissues predicts diverse functions. Proc Natl Acad Sci USA 85:247-251
31. Mine T, Kojima I, Ogata E (1989) Stimulation of glucose production by activin A in isolated rat hepatocytes. Endocrinology 125:586-591
32. Ogawa K, Abe K, Kurosawa N, Kurohmaru M, Sugino H, Takahashi M, Hayashi Y (1993) Expression of α, βA and βB subunits of inhibin or activin and follistatin in rat pancreatic islets. FEBS Lett 319:217-220
33. Ogawa K, Ono K, Kurohmaru M, Hayashi Y (1995) Effect of streptozotocin injection on expression of immunoreactive follistatin and βA and βB subunits of inhibin/activin in rat pancreatic islets. Eur J Endocrinol 132:363-369
34. Risbridger GP, Schmitt JF, Robertson DM (2001) Activins and inhibins in endocrine and other tumors. Endocrine Rev 22:836-858
35. Roberts VJ, Barth S, El-Roeiy A, Yen SSC (1993) Expression of inhibin/activin subunits, follistatin mRNAs and proteins in ovarian follicles and the corpus luteum during the human mestrual cycle. J Clin Endocrinol Metab 77:1402-1410
36. Roberts VJ, Barth S, El-Roeiy A, Yen SSC (1994) Expression of inhibin/activin system messenger ribonucleic acids and proteins in ovarian follicles from women with polycystic ovarian syndrome. J Clin Endocrinol Metab 79:1434-1439
37. Salmenkivi K, Arola J, Voutilainen R, Ilvesmaki V, Haglund C, Kahri AI, Heikkilla P, et al. (2001) Inhibin/activin βB-subunit expression in pheochromocytomas favors benign diagnosis. J Clin Endocrinol Metab 86:2231-2235
38. Schneider O, Nau R, Michel U (2000) Comparative analysis of follistatin-, activin beta A- and activin beta B-mRNA steady-state levels in diverse porcine tissues by multiplex S1 nuclease analysis. Eur J Endocrinol 142:537-544
39. Shimasaki S, Koga M, Buscaglia ML, Simmons DM, Bicsak TA, Ling N (1989) Follistatin gene expression in the ovary and extragonadal tissues. Mol Endocrinol 3:651-659
40. Shimonaka M, Inouye S, Shimasaki S, Ling N (1991) Follistatin binds to both activin and inhibin through the common beta-subunit. Endocrinology 128:3313-3315
41. Solcia E, Rindi G, Paolotti D, La Rosa S, Capella C, Fiocca R (1999) Clinicopathological profile as a basis for classification of the endocrine tumours of the gastroenteropancreatic tract. Ann Oncol 10(suppl 2):S9-15
42. Spencer SJ, Rabinovici J, Mesiano S, Goldsmith PC, Jaffe RB (1992) Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells. J Clin Invest 90:142-149
43. Stewart AG, Milborrow HM, Ring JM, Crowther CE, Forage RG (1986) Human inhibin genes: genomic characterization and sequencing. FEBS Lett 206:329-334
44. Totsuka Y, Tabuchi M, Kojima I, Shibai H, Ogata E (1988) A novel action of activin A: stimulation of insulin secretion in rat pancreatic islets. Biochem Biophys Res Commun 156:335-339
45. Ueno N, Ling N, Ling SY, Esch F, Shimasaki S, Guillemin R (1987) Isolation and partial characterization of follistatin, a novel Mr 35,000 monomeric protein which inhibits the release of follicle stimulating hormone. Proc Natl Acad Sci USA 84:8282-8286
46. Unger RH, Orci L (1976) Physiology and pathophysiology of glucagon. Physiol Rev 56:778-826
47. Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, Karr D, et al. (1986) Purification and characterization of a FSH-releasing protein from porcine ovarian follicular fluid. Nature 321:776-779
48. Verspohl EJ, Ammon HP, Wahl MA (1993) Activin A: its effects on rat pancreatic islets and the mechanism of action involved. Life Sci 53:1069-1078
49. Wada M, Shitani Y, Kosaka M, Sano T, Hizawa K, Saito S (1996) Immunohistochemical localization of activin A and follistatin in human tissues. Endocrine J 43:375-385
50. Yamaoka T, Idehara C, Yano M, Matsushita T, Yamada T, Ii S, Moritani M, et al. (1998) Hypoplasia of pancreatic islet in transgenic mice expressing activin receptor mutants. J Clin Invest 102:294-301
51. Yasuda H, Inoue K, Shibata H, Takeuchi T, Eto Y, Hasegawa Y, Sekine N, et al. (1993) Existence of activin-A in A- and D-cells of rat pancreatic islet. Endocrinology 133:624-630
52. Zheng W, Lauchlan SC (1999) Inhibin and activin: their roles in ovarian tumorigenesis and their diagnostic utility in surgical pathology practice. Appl Immunohistochem Mol Morphol 7:29-38