DNA sequencing-based HLA typing detects a B-cell ALL blast-specific mutation in HLA-A*2402 resulting in loss of HLA allele expression [7]

Leukemia

Volumn 18, Issue 1, 2004, Pages 174-176

  Sayer, D C ^a,b   Smith, L K ^a   Krueger, R ^a   Chrisitansen, F T ^a,b  

^a ROYAL PERTH HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIGEN EXPRESSION; B CELL LEUKEMIA; BASE PAIRING; BONE MARROW TRANSPLANTATION; CANCER IMMUNOTHERAPY; CELL KILLING; CELL PROLIFERATION; CHROMOSOME ABERRATION; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE LOSS; GENE MUTATION; HLA TYPING; HUMAN; IMMUNOSURVEILLANCE; LETTER; LEUKEMIA CELL; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RNA TRANSLATION; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0742272091     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403150     Document Type: Letter

References (5)

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2. Brouwer RE, van der HP, Schreuder GM, Mulder A, Datema G, Anholts JD et al. Loss or downregulation of HLA class I expression at the allelic level in acute leukemia is infrequent but functionally relevant, and can be restored by interferon. Hum Immunol 2002; 63: 200-210.
3. Maleno I, Lopez-Nevot MA, Cabrera T, Salinero J, Garrido F. Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21. Cancer Immunol Immunother 2002; 51: 389-396.
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5. Tsuboi A, Oka Y, Udaka K, Murakami M, Masuda T, Nakano A et al. Enhanced induction of human WT1-specific cytotoxic T lymphocytes with a 9-mer WT1 peptide modified at HLA-A 2402-binding residues. Cancer Immunol Immunother 2002; 51: 614-620.