Zidovudine-induced alterations in the heart and vascular smooth muscle of the rat

Cardiovascular Research

Volumn 60, Issue 1, 2003, Pages 147-155

  Ruga, Ezia ^a   Bova, Sergio ^a,b   Nussdorfer, Gastone ^a   Mazzocchi, Giuseppina ^a   Rebuffat, Piera ^a   Milanesi, Ornella ^a   Cargnelli, Gabriella ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Dept of Pharmacol and Anesth ^*  (Italy)

Author keywords

Blood pressure; Contractile function; Electron microscopy; Heart; Mitochondria; Smooth muscle; Zidovudine

Indexed keywords

CARBACHOL; DRINKING WATER; PHENYLEPHRINE; POTASSIUM CHLORIDE; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; CARDIOTOXICITY; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; HEART FUNCTION; HEART HYPERTROPHY; HEART MITOCHONDRION; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE SEPTUM; HEART WEIGHT; HISTOPATHOLOGY; IN VITRO STUDY; MALE; MICROSCOPY; MORPHOLOGY; MUSCLE CELL; MUSCLE EXCITATION; MUSCLE FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION; SYSTOLIC BLOOD PRESSURE; THICKNESS; TOXICITY TESTING; VASCULAR ENDOTHELIUM; VASCULAR RING; VASCULAR SMOOTH MUSCLE; ANIMAL; AORTA; DOSE RESPONSE; HEART; HEART CONTRACTION; HEART VENTRICLE; ULTRASTRUCTURE; WISTAR KYOTO RAT;

ANIMALS; ANTI-HIV AGENTS; AORTA; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOCARDIOGRAPHY; ENDOTHELIUM, VASCULAR; HEART; HEART VENTRICLES; MALE; MICROSCOPY, ELECTRON; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHENYLEPHRINE; POTASSIUM CHLORIDE; RATS; RATS, INBRED WKY; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS; ZIDOVUDINE;

EID: 0642373573     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00364-X     Document Type: Article

References (25)

1. Hao Z., Cooney D.A., Hartman N.R., et al. Factors determining the activity of 2′,3′-dideoxynucleotides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 34:1988;431-435.
2. Brinkman K., ter Hofstede H., Burger D.M., Smeitink J., Koopmans P.P. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway. AIDS. 12:1998;1735-1744.
3. Lewis W., Simspon S., Meyer R.R. Cardiac mitochondrial DNA polymerase-γ is inhibited competitively and non competitively by phosphorylated zidovudine. Circ Res. 74:1994;344-348.
4. Dalakas M.C., Illa I., Pezeshkpour G.H., et al. Mitochondrial myopathy caused by long-term zidovudine therapy. New Engl J Med. 322:1990;1098-1105.
5. Lewis W., Grupp I.L., Grupp G., et al. Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine. Lab Invest. 80:2000;187-197.
6. Lewis W., Papoian A.T., Gonzales B., et al. Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts. Lab Invest. 65:1991;228-236.
7. Lamperth L., Dalakas M.C., Dagani F., Anderson J., Ferrari R. Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model. Lab Invest. 65:1991;742-751.
8. Cazzalini O., Lazzè M.C., Iamele L., et al. Early effects of AZT on mitochondrial functions in the absence of mitochondrial DNA depletion in rat myotubes. Biochem Pharmacol. 62:2001;893-902.
9. Herskowitz A., Willoughby S.B., Baughmann K.L., Schulman S.P., Bartlett J.D. Cardiomyopathy associated with antiretroviral therapy in patients with HIV infections: a report of six cases. Ann Intern Med. 116:1992;311-313.
10. Domanski M.J., Sloas M.M., Follmann D.A., et al. Effect of zidovudine and didanosine treatment on heart function in children infected with human immunodeficiency virus. J Pediatr. 127:1995;137-146.
11. Engbretson B.G. Effect of zidovudine (AZT) on the structure and function of rat skeletal muscle. Can J Physiol Pharmacol. 74:1996;679-686.
12. Cargnelli G., Debetto P., Trevisi L., Luciani S., Bova S. Effect of long-term ouabain treatment on contractile responses of rat aortae. J Cardiovasc Pharmacol. 35:2000;538-542.
13. Sahn D.J., De Maria A., Kisslo J., Weymann A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 58:1978;1072-1080.
14. Bova S., Trevisi L., Debetto P., et al. Vasorelaxant properties of norbormide, a selective vasoconstrictor agent of the rat microvasculature. Br J Pharmacol. 117:1996;1041-1046.
15. Rossi G.P., Bova S., Sacchetto A., et al. Comparative effects of the dual ACE-NEP inhibitor MDL-100,240 and ramipril on hypertension and cardiovascular disease in endogenous angiotensin II-dependent hypertension. Am J Hypertension. 15:2002;181-188.
16. Rebuffat P., Belloni A.S., Malendowicz L.K., et al. Zona glomerulosa morphology and function in streptozotocin-induced diabetic rats. Endocrinology. 123:1988;949-955.
17. Colan S.D., Spevak P.J., Parness I.A., Nadas A.S. Cardiomyopathies. Hanley J., Belfus H. Nadas' pediatric cardiology. 1992;329-361.
18. Karaki H., Ozaki H., Hori M., et al. Calcium movements, distribution and functions in smooth muscle. Pharmacol Rev. 49:1997;157-230.
19. Moncada S., Palmer R.M., Higgs E.A. Nitric oxide: physiology, pathology and pharmacology. Pharmacol Rev. 43:1991;109-142.
20. Pearson P.J., Vanhoutte P.M. Vasodilator and vasoconstrictor substances produced by the endothelium. Rev Physiol Biochem Pharmacol. 122:1993;1-67.
21. Barbaro G., Di Lorenzo G., Soldini M., et al. Intensity of myocardial expression of inducible nitric oxide synthase influences the clinical course of human immunodeficiency virus-associated cardiomyopathy. Circulation. 100:1999;633-639.
22. Spector S., Fleisch J.H., Maling H.M., Brodie B.B. Vascular smooth muscle reactivity in normotensive and hypertensive rats. Science. 166:1969;1300-1301.
23. Shibata S., Kurakashi K., Kuchii M. A possible etiology of contractility impairment of vascular smooth muscle from spontaneously hypertensive rats. J Pharmacol Exp Ther. 185:1973;406-417.
24. Cargnelli G., Rossi G.P., Bova S., Pessina A.C. In vitro vascular reactivity to endothelin: a comparison between young and old normotensive and hypertensive rats. Clin Exp Hypertension. 12:1990;1437-1451.
25. Stratton D.B., Marrow R.J., Sanders B.J. Vascular responsiveness in the unstressed borderline hypertensive rats. Clin Exp Hypertension. 16:1994;105-117.