Functional analysis of Ras in Colletotrichum trifolii

FEMS Microbiology Letters

Volumn 226, Issue 2, 2003, Pages 315-321

  Ha, Young Sil ^a   Memmott, Stephen D ^a   Dickman, Martin B ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Antisense; Fungal signal transduction; G protein

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; RAS PROTEIN; CHROMONE DERIVATIVE; COMPLEMENTARY RNA; FARNESYL TRANS TRANSFERASE; FUNGAL PROTEIN; FUSIDIENOL; OXEPINE DERIVATIVE; TRANSFERASE;

ARTICLE; COLLETOTRICHUM; CYTOSOL; FIBROBLAST; FUNGUS GROWTH; FUNGUS HYPHAE; GENE DISRUPTION; NONHUMAN; NUTRIENT; ONCOGENE RAS; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CYTOLOGY; DRUG ANTAGONISM; ESSENTIAL GENE; FUNGAL GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MISSENSE MUTATION; PROMOTER REGION;

COLLETOTRICHUM; COLLETOTRICHUM TRIFOLII; EUKARYOTA; MAMMALIA; MEDICAGO SATIVA;

ALKYL AND ARYL TRANSFERASES; CHROMONES; COLLETOTRICHUM; FARNESYLTRANSTRANSFERASE; FUNGAL PROTEINS; GENES, ESSENTIAL; GENES, FUNGAL; GTP-BINDING PROTEINS; HYPHAE; MUTAGENESIS, INSERTIONAL; MUTATION, MISSENSE; OXEPINS; PROMOTER REGIONS (GENETICS); RAS PROTEINS; RNA, ANTISENSE; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 0642316132     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(03)00589-5     Document Type: Article

References (32)

1. Aznar S., Lacal J.C. Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors. Prog. Nucleic Acid Res. Mol. Biol. 67:2001;193-234.
2. Gibbs J.B. Ras C-terminal processing enzymes-new drug targets? Cell. 65:1991;1-4.
3. Magee T., Marshall C. New insights into the interaction of Ras with the plasma membrane. Cell. 98:1999;9-12.
4. Bourne H.R., Sanders D.A., McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 348:1990;125-132.
5. Boguski M.S., McCormick F. Proteins regulating Ras and its relatives. Nature. 366:1993;643-654.
6. Cool R.H., Schmidt G., Lenzen C.U., Prinz H., Vogt D., Wittinghofer A. The Ras mutant D119N is both dominant negative and activated. Mol. Cell. Biol. 19:1999;6297-6305.
7. Adjei A.A. Blocking oncogenic Ras signaling for cancer therapy. J. Natl. Cancer Inst. 93:2001;1062-1074.
8. Som T., Kolaparthi V.S. Developmental decisions in Aspergillus nidulans are modulated by Ras activity. Mol. Cell. Biol. 14:1994;5333-5348.
9. Kana-uchi A., Yamashiro C.T., Tanabe S., Murayama T. A ras homologue of Neurospora crassa regulates morphology. Mol. Gen. Genet. 254:1997;427-432.
10. Lee N., Kronstad J.W. ras2 Controls Morphogenesis, Pheromone Response, and Pathogenicity in the Fungal Pathogen Ustilago maydis. Eukaryot. Cell. 1:2002;954-966.
11. Park S.Y., Lee E.J., Lee C.W. Molecular cloning and sequence analysis of a putative ras gene of the phytopathogenic fungus Botryotinia fuckeliana. Mol. Cell. 7:1997;300-304.
12. Truesdell G.M., Jones C., Holt T., Henderson G., Dickman M.B. A Ras protein from a phytopathogenic fungus causes defects in hyphal growth polarity, and induces tumors in mice. Mol. Gen. Genet. 262:1999;46-54.
13. Osherov N., May G.S. The molecular mechanisms of conidial germination. FEMS Microbiol. Lett. 199:2001;153-160.
14. Memmott S.D., Ha Y.S., Dickman M.B. Proline reverses the abnormal phenotypes of Colletotrichum trifolii associated with expression of endogenous constitutively active Ras. Appl. Environ. Microbiol. 68:2002;1647-1651.
15. Fujimura K., Tanaka K., Toh-e A. A dominant interfering mutation in RAS1 of Saccharomyces cerevisiae. Mol. Gen. Genet. 241:1993;280-286.
16. Mbonyi K., Beullens M., Detremerie K., Geerts L., Thevelein J.M. Requirement of one functional RAS gene and inability of an oncogenic ras variant to mediate the glucose-induced cyclic AMP signal in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 8:1988;3051-3057.
17. Sliter T.J., Henrich V.C., Tucker R.L., Gilbert L.I. The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: analysis of recessive lethal mutations. Genetics. 123:1989;327-336.
18. Ashar H.R., James K., Gray D., Carr S., Black L., Armstrong W.R., Kirschmeier P. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J. Biol. Chem. 275:2000;30451-30457.
19. Dickman M.B., Buhr T.L., Warwar V., Truesdell G.M., Huang C. Molecular signals during early stages of alfalfa anthracnose. Can. J. Bot. 73:1995;1169-1177.
20. Roze L.V., Mahanti N., Mehigh R., McConnell D.G., Linz J.E. Evidence that MRas1 and MRas3 proteins are associated with distinct cellular functions during growth and morphogenesis in the fungus Mucor racemosus. Fungal Genet. Biol. 28:1999;171-189.
21. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
22. Truesdell G.M., Yang Z., Dickman M.B. A G alpha sub-unit from the phytopathogenic fungus Colletotrichum trifolii is required for conidial germination. Physiol. Mol. Plant Pathol. 56:2000;131-140.
23. Geever R.F., Huiet L., Baum J.A., Tyler B.M., Patel V.B., Rutledge B.J., Case M.E., Giles N.H. DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa. J. Mol. Biol. 207:1989;15-34.
24. Lengeler K.B., Davidson R.C., D'Souza C., Harashima T., Shen W.C., Wang P., Pan X., Waugh M., Heitman J. Signal transduction cascades regulating fungal development and virulence. Microbiol. Mol. Biol. Rev. 64:2000;746-785.
25. Ding S.F., Lombardi R., Nazari R., Joshi S. A combination anti-HIV-1 gene therapy approach using a single transcription unit that expresses antisense, decoy, and sense RNAs, and trans-dominant negative mutant Gag and Env proteins. Front. Biosci. 7:2002;15-28.
26. Green P.J., Pines O., Inouye M. The role of antisense RNA in gene regulation. Annu. Rev. Biochem. 55:1986;569-597.
27. Judelson H.S., Dudler R., Pieterse C.M., Unkles S.E., Michelmore R.W. Expression and antisense inhibition of transgenes in Phytophthora infestans is modulated by choice of promoter and position effects. Gene. 133:1993;63-69.
28. Roze L.V., Linz J.E. Lovastatin triggers an apoptosis-like cell death process in the fungus Mucor racemosus. Fungal Genet. Biol. 25:1998;119-133.
29. Warwar V., Oved X., Dickman M.B. Antisense expression of the calmodulin gene from Colletotrichum trifolii impairs prepenetration development(1). FEMS Microbiol. Lett. 191:2000;213-219.
30. Yang Z., Dickman M.B. Regulation of cAMP and cAMP dependent protein kinase during conidial germination and appressorium formation in Colletotrichum trifolii. Physiol. Mol. Plant Pathol. 50:1997;117-127.
31. Yang Z., Dickman M.B. Colletotrichum trifolii mutants disrupted in the catalytic subunit of cAMP-dependent protein kinase are non-pathogenic. Mol. Plant Microbe Interact. 12:1999;430-439.
32. Dickman M.B., Ha Y.S., Yang Z., Adams B., Huang C. A protein kinase from Colletotrichum trifolii is induced by plant cutin and is required for appressorium formation. Mol. Plant Microbe Interact. 16:2003;411-421.