Effect of gamma irradiation on toxicity and immunogenicity of Androctonus australis hector venom

Canadian Journal of Physiology and Pharmacology

Volumn 81, Issue 12, 2003, Pages 1118-1124

  Abib, Lila ^a   Laraba Djebari, Fatima ^a,b  

^a UNIVERSITY OF SCIENCES AND TECHNOLOGY HOUARI BOUMEDIENE   (Algeria)

^b Institut Pasteur d'Algerie   (Algeria)

Author keywords

Androctonus australis hector; Gamma irradiation; Immunogenicity; In vivo protection; Venom

Indexed keywords

ANTIBODY; ANTISERUM; SCORPION VENOM;

ACTIVE IMMUNIZATION; ANDROCTONUS AUSTRALIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GAMMA IRRADIATION; GAMMA RADIATION; IMMUNOGENICITY; IMMUNOREACTIVITY; LD 50; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIVITY; SCORPION; TOXICITY TESTING;

ACUTE TOXICITY TESTS; ANIMALS; ANTIVENINS; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GAMMA RAYS; IMMUNE SERA; IMMUNIZATION SCHEDULE; INJECTIONS, INTRAPERITONEAL; LETHAL DOSE 50; MALE; MICE; MICE, INBRED STRAINS; NEUTRALIZATION TESTS; RABBITS; SCORPION VENOMS;

EID: 0442291692     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y03-115     Document Type: Article

References (30)

1. Antoni, F. 1967. The effect of ionizing radiation on some molecules of biological importance. In Radiosterilization of medical products and recommended code of practice. International Atomic Energy Agency, Vienna. pp. 13-20.
2. Behrens, B., and Karber, G. 1935. Wie sind reihenversuche fur-biologische auswertungenam zweckmassigsten anzuordnen. Arch. Exp. Pathol. Pharmacol. 177: 379-388.
3. Buther, J., Land, E.J., and Swallow, J. 1984. Chemical mechanisms of effects of high energy radiation systems. Radiat. Phys. Chem. 24: 273-282.
4. Clissa, B.P., Nascimento, N.D., and Rogero, J.R. 1999. Toxicity and immunogenicity of Crotalus durissus terrificus venom treated with different doses of gamma rays. Toxicon, 37: 1131-1141.
5. Fontecilla-Camps, J.C., Almassy, R.J., Suddath, F.L., and Bugg, C.E. 1982. The three-dimensional structure of scorpion neurotoxins. Toxicon, 20: 1-7.
6. Fontecilla-Camps, J.C., Rochat, C., and Rochat, H. 1988. Orthorhombic crystals and three-dimensional structure of potent toxin II from the scorpion Androctonus australis hector. Proc. Natl. Acad. Sci. U.S.A. 85: 7443-7447.
7. Hati, R.N., Mandal, M., and Hati, A.K. 1990. Active immunization of rabbit with gamma irradiated Russell's viper venom toxoid. Toxicon, 28: 895-902.
8. Ismail, M. 1995. The scorpion envenoming syndrome. Toxicon, 33: 825-858.
9. Kondo, H., Kondo, S., Sadahiro, S., Yamanuchi, K., and Murata, R. 1972. Immunogenicity of purified toxoid of Habu (Trimeresurus flavoviridis) venom. Jpn. J. Med. Sci. Biol. 25: 201-203.
10. Kopeyan, C., Martinez, G., Lissitzky, S., Miranda, F., and Rochat, H. 1974. Dissulfide bonds of the toxin AaH II. Eur. J. Biochem. 47: 483-489.
11. Laraba-Djebari, F., and Hammoudi, D. 1998. Utilisation de la fraction toxique majoritaire isolée à partir du venin dans la valorisation du sérum antiscorpionique. Arch. Inst. Pasteur Alger. T62: 254-266.
12. Lauhatirananda, P., Ganthavorn, S., and Hayodom, V. 1970. Radiation effects on cobra venom. In Radiation sensitivity of toxins and animal poisons. Proceedings of a panel organized by the International Atomic Energy Agency, Bangkok, 19-22 May 1969. International Atomic Energy Agency, Vienna. pp. 107-112.
13. Lowry, O.K., Rosebrough, N.T., Farr, A.L., and Randall, R.J. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275.
14. Mandal, M., Hati, R.N., and Hati, A.K. 1993. Neutralisation of pathophysiological manifestations of Russell's viper envenoming by antivenom raised against gamma-irradiated toxoid. Toxicon, 31: 213-216.
15. Martin, M.F., and Rochat, H. 1984. Purification and aminoacid sequence of toxin I″ from the venom of the North African scorpion Androctonus australis hector. Toxicon, 22: 695-703.
16. Martin, M.F., and Rochat, H. 1986. Purification of toxins from the venom of the scorpion Androctonus australis hector. Toxicon, 24: 1131-1139.
17. Miranda, F., Kopeyan, C., Rochat, C., and Lissitsky, S. 1970. Isolation and characterization of eleven neurotoxins from the venom of the scorpion Androctonus australis hector, Buthus occitanis tunetanus and Leiurus quinquestriatus quinquestriatus. Eur. J. Biochem. 16: 514.
18. Moreira-Ferreira, A.M.B., Kalapothakis, E., Diniz, C.R., and Chávez-Olórtegui, C. 1998. In vivo protection against Tityus serrulatus scorpion toxins by immunization of mice with a nontoxic protein. Toxicon, 36: 333-339.
19. Murata, Y., Nishikawa, A.K., Nascimento, N., Higashi, H.G., Dias Da Silva, W., and Rogero, J.R. 1990. Gamma radiation reduces the toxic activities of Crotalus durissus terrificus venom but does not affect their immunogenic activities. Toxicon, 28: 617.
20. Nascimento, N., Seebart, C., Francis, B., Rogero, J.R., and Kaiser, I.I. 1996. Influence of ionizing radiation on crotoxin: biochemical and immunological aspects. Toxicon, 34: 121-131.
21. Osnaya-Romero, N., de Jesus Medina-Hernández, T., Flores-Hernández, S.S., and León-Rojas, G. 2001. Clinical symptoms observed in children envenomated by scorpion stings at the children's hospital from the state of Malos, Mexico. Toxicon, 39: 781-785.
22. Revelo, M.P., Bambirra, E.A., Ferreira, A.P., Diniz, C.R., and Chavez-Ortegui, C. 1996. Body distribution of Tityus serrulatus scorpion and effects of scorpion antivenom. Toxicon, 34: 1119-1125.
23. Rezende, N.A., Dias, M.B., Campolino, D., Chavez-Olortegui, C., Diniz, C.R., and Amaral, C.F.S. 1995. Efficacy of antivenom therapy for neutralizing circulating venom antigens in patients stung by Tityus serrulatus scorpions. Am. J. Trop. Med. Hyg. 52: 277-280.
24. Rochat, H., Rochat, C., Miranda, F., and Lissitsky, S. 1970. The aminoacid sequence of neurotoxin I of Androctonus australis hector. Eur. J. Biochem. 17: 292-266.
25. Rogero, J.R., and Nascimento, N. 1995. Detoxification of snake venom using ionizing radiation. J. Venom. Anim. Toxins, 1: 7-10.
26. Salafranca, E.S. 1972. Irradiated cobra (Naja naja philippinensis) venom. Jpn. J. Med. Sci. Biol. 25: 206.
27. Skalka, M., and Antoni, F. 1970. Effect of radiation on the biological properties of proteins. In Radiation sensitivity of toxins and animal poisons. Proceedings of a panel organized by the International Atomic Energy Agency, Bangkok, 19-22 May 1969. International Atomic Energy Agency, Vienna. pp. 1-11.
28. Spencer, P.J. 2000. A effects of radiation on the structure of Bothropstoxin-1. J. Venom. Anim. Toxins, 6: 282.
29. Sundaram, K., Philip, J., and Bhatt, M.B. 1970. Radiation effects on Naja naja venom and polyvalent antisera. In Radiation sensitivity of toxins and animal poisons. Proceedings of a panel organized by the International Atomic Energy Agency, Bangkok, 19-22 May 1969. International Atomic Energy Agency, Vienna. pp. 99-106.
30. Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76: 4350-4354.