Toxicity and immunogenicity of Crotalus durissus terrificus venom treated with different doses of gamma rays

Toxicon

Volumn 37, Issue 8, 1999, Pages 1131-1141

  Clissa, Patricia Bianca ^a   Do Nascimento, Nanci ^a   Rogero, José Roberto ^a  

^a Coordenadoria Bioengenharia I ^*  (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

SNAKE VENOM;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG TOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GAMMA IRRADIATION; IMMUNOGENICITY; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE;

ANIMALS; BLOTTING, WESTERN; CHROMATOGRAPHY, GEL; CROTALUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GAMMA RAYS; IMMUNE SERA; IMMUNIZATION, PASSIVE; NEUTRALIZATION TESTS; RABBITS; SNAKE VENOMS; SURVIVAL RATE;

CROTALUS; CROTALUS DURISSUS TERRIFICUS;

EID: 0032956476     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(98)00249-9     Document Type: Article

References (22)

1. Aird S.D., Kaiser I.I. Toxicity assays. Toxicon. 23:1985;11-13.
2. Angulo Y., Estrada R., Gutiérrez J.M. Clinical and laboratorial alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom. Toxicon. 35:1997;81-90.
3. Butter J., Land E.J., Swallow J. Chemical mechanisms of the effects of high energy radiation systems. Radiat. Phys. Chem. 24:1984;273-282.
4. Baride M., Jain S.D., Gaitonde B.B. Biochemical studies on toxoids of venoms of poisonous Indian snakes. Indian. J. Med. Res. 72:1980;571-576.
5. Bradford M.M. A rapid and sensitive method for quantitation of μg quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 72:1976;248-253.
6. Cardoso D.F., Mota I. Effect of Crotalus venom on the humoral and cellular immune response. Toxicon. 35:1997;607-612.
7. Costa L.M., Takeda A.K., Barbosa S.F.C., Berra J.A.P., Adelino M.G.F., Soerensen B., Pinto J.R., Vancetto M.D.C. Estudo comparativo da resposta imune de cavalos ao veneno de Crotalus durissus terrificus, in natura, tratado com formaldeído e submetido à ação térmica. Vac. Soros. 1:1985;24-29.
8. Daniel J.P., Heneine L.G.D., Tavares C.A.P., Nascimento M.C.S., Heneine I.F. Generation of protective immune sera by Crotalus durissus terrificus venom detoxified by controlled iodination. Braz. J. Med. Biol. Res. 20:1987;713-720.
9. Freitas T.V., Frézard F. Encapsulation of native crotoxin in liposomes: a safe approach for the production of antivenom and vaccination against Crotalus durissus terrificus venom. Toxicon. 35:1997;91-100.
10. Hati R.N., Mandal M., Hati A.K. Active immunisation of rabbit with gamma irradiated Russel's viper venom toxoid. Toxicon. 28:1990;895-902.
11. Kaiser I.I., Middlebrook J.L., Crumrine M.H., Stevenson W.W. Cross-reactive and neutralisation by rabbit antiserum raised against crotoxin, its subunits and two related toxins. Toxicon. 24:1986;669-678.
12. Kume T., Matsuda T. Changes in structural and antigenic properties of proteins by radiation. Radiat. Phys. Chem. 46:1995;225-231.
13. Mandal M., Hati R.N., Hati A.K. Neutralization of pathophysiological manifestations of Russell's viper envenoming by antivenom raised against gamma-irradiated toxoid. Toxicon. 31:1993;213-216.
14. Moroz C., Goldblum N., Vries A. Preparation of Vipera palestinae antineurotoxin using carboxymethylcellulose-bound neurotoxin as antigen. Nature. 200:1963;697-698.
15. Murata Y., Nishikawa A.K., Nascimento N., Higashi H.G., Dias Da Silva W., Rogero J.R. Gamma radiation reduces the toxic activities of Crotalus durissus terrificus venom but does not affect their immunogenic activities. Toxicon. 28:1990;617.
16. Nascimento N., Seebart C., Francis B., Rogero J.R., Kaiser I.I. Influence of ionizing radiation on crotoxin: biochemical and immunological aspects. Toxicon. 34:1996;121-131.
17. Rogero J.R., Nascimento N. Detoxification of snake venom using ionizing radiation. J. Venom. Anim. Toxins. 1:1995;7-10.
18. 2 injection in mice induces immunity against the lethal effects of Crotalus durissus terrificus venom. Toxicon. 26:1988;207-213.
19. Scheaffer R.C. Jr., Randal H., Resk J., Carlson R.W. Enzyme-linked immunosorbent assay (ELISA) of size selected crotalic venom antigens by Wyeth's polyvalent antivenom. Toxicon. 26:1988;67-76.
20. Skalka, M., Antoni, F., 1970. Effect of radiation on the biological properties of proteins. In: Radiation Sensitivity of Toxins and Animal Poisons, 1969, Bangkok. Proceedings of a Panel Bangkok. 19-22 May, 1969. International Atomic Energy Agency, Vienna, pp. 1-11.
21. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
22. WHO, 1981. Progress in characterization of venoms and standardisation of antivenoms. WHO Offset Publ. No. 58.