Quorum sensing in Staphylococcus infections

Journal of Clinical Investigation

Volumn 112, Issue 11, 2003, Pages 1620-1625

  Yarwood, Jeremy M ^a   Schlievert, Patrick M ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRULENCE FACTOR;

ACCESSORY GENE REGULATOR; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL VIRULENCE; BIOFILM; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; QUORUM SENSING SYSTEM; REVIEW; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS INFECTION;

BACTERIAL PROTEINS; BIOFILMS; GENE EXPRESSION REGULATION, BACTERIAL; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; TRANS-ACTIVATORS; VIRULENCE;

EID: 0348230956     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200320442     Document Type: Review

References (43)

1. Tenover, F.C., and Gaynes, R.P. 2000. The epidemiology of Staphylococcus aureus infections. In Gram-positive pathogens. V.A. Fischetti, R.P. Novick, J.J. Ferretti, D.A. Portnoy, and J.I. Rood, editors. ASM Press. Washington, DC, USA. 414-421.
2. Raad, I., Alrahwan, A., and Rolston, K. 1998. Staphylococcus epidermidis: emerging resistance and need for alternative agents. Clin. Infect. Dis. 26:1182-1187.
3. Gotz, F. 2002. Staphylococcus and biofilms. Mol. Microbiol. 43:1367-1378.
4. Vuong, C., Gotz, F., and Otto, M. 2000. Construction and characterization of an agr deletion mutant of Staphylococcus epidermidis. Infect. Immun. 68:1048-1053.
5. Novick, R.P. 2003. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol. Microbiol. 48:1429-1449.
6. Bunce, C., Wheeler, L., Reed, G., Musser, J., and Barg, N. 1992. Murine model of cutaneous infection with gram-positive cocci. Infect. Immun. 60:2636-2640.
7. Abdelinour, A., Arvidson, S., Bremell, T., Ryden, C., and Tarkowski, A. 1993. The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect. Immun. 61:3879-3885.
8. - mutant of Staphylococcus aureus in the rabbit model of endocarditis. J. Clin. Invest. 94:1815-1822.
9. Wesson, C.A., et al. 1998. Staphylococcus aureus Agr and Sar global regulators influence internalization and induction of apoptosis. Infect. Immun. 66:5238-5243.
10. Yarwood, J.M., McCormick, J.K., Paustian, M.L., Kapur, V., and Schlievert, P.M. 2002. Repression of the Staphylococcus aureus accessory gene regulator in serum and in vivo. J. Bacteriol. 184:1095-1101.
11. Goerke, C., et al. 2000. Direct quantitative transcript analysis of the agr regulon of Staphylococcus aureus during human infection in comparison to the expression profile in vitro. Infect. Immun. 68:1304-1311.
12. Goerke, C., Fluckiger, U., Steinhuber, A., Zimmerli, W., and Wolz, C. 2001. Impact of the regulatory loci agr, sarA and sae of Staphylococcus aureus on the induction of α-toxin during device-related infection resolved by direct quantitative transcript analysis. Mol. Microbiol. 40:1439-1447.
13. Giraudo, A.T., Cheung, A.L., and Nagel, R. 1997. The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level. Arch. Microbiol. 168:53-58.
14. Giraudo, A.T., Calzolari, A., Cataldi, A.A., Bogni, C., and Nagel, R. 1999. The sae locus of Staphylococcus aureus encodes a two-component regulatory system. FEMS Microbiol. Lett. 177:15-22.
15. Giraudo, A.T., Mansilla, C., Chan, A., Raspanti, C., and Nagel, R. 2003. Studies on the expression of regulatory locus sae in Staphylococcus aureus. Curr. Microbiol. 46:246-250.
16. Fournier, B., and Hooper, D.C. 2000. A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus. J. Bacteriol. 182:3955-3964.
17. Fournier, B., Klier, A., and Rapoport, G. 2001. The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureus. Mol. Microbiol. 41:247-261.
18. Yarwood, J.M., McCormick, J.K., and Schlievert, P.M. 2001. Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureas. J. Bacteriol. 183:1113-1123.
19. Throup, J.P., et al. 2001. The srhSR gene pair from Staphylococcus aureas: genomic and proteomic approaches to the identification and characterization of gene function. Biochemistry. 40:10392-10401.
20. Cheung, A.L., and Zhang, G. 2002. Global regulation of virulence determinants in Staphylococcus aureus by the SarA protein family. Front. Biosci. 7:1825-1842.
21. Cheung, A.L., Bayer, M.G., and Heinrichs, J.H. 1997. sar genetic determinants necessary for transcription of RNAII and RNAIII in the agr locus of Staphylococcus aureus. J. Bacteriol. 179:3963-3971.
22. SB of Staphylococcus aureus: characterization and role in transcription of the global regulatory locus sar. J. Bacteriol. 179:6355-6359.
23. McNamara, P.J., Milligan-Monroe, K.C., Khalili, S., and Proctor, R.A. 2000. Identification, cloning, and initial characterization of rot, a locus encoding a regulator of virulence factor expression in Staphylococcus aureus. J. Bacteriol. 182:3197-3203.
24. Said-Salim, B., et al. 2003. Global regulation of Staphylococcus aureus genes by Rot. J. Bacteriol. 185:610-619.
25. B controls the environmental stress response but not starvation survival or pathogenicity in a mouse abscess model. J. Bacteriol. 180:6082-6089.
26. Nicholas, R.O., et al. 1999. Isolation and characterization of a sigB deletion mutant of Staphylococcus aureus. Infect. Immun. 67:3667-3669.
27. Donlan, R.M., and Costerton, J.W. 2002. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin. Microbiol. Rev. 15:167-193.
28. van Wamel, W., et al. 2002. Regulation of Staphylococcus aureus type 5 capsular polysaccharides by agr and sarA in vitro and in an experimental endocarditis model. Microb. Pathog. 33:73-79.
29. Gillaspy, A., et al. 1995. Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis. Infect. Immun. 63:3373-3380.
30. Blevins J.S., et al. 2003. Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infect. Immun. 71:516-523.
31. Akiyama, H., et al. 2003. Confocal laser scanning microscopic observation of glycocalyx production by Staphylococcus aureus in skin lesions of bullous impetigo, atopic dermatitis and pemphigus foliaceus. Brit. J. Dermatol. 148:526-532.
32. Li, Y.H., et al. 2002. A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation J. Bacteriol. 184:2699-2708.
33. Davies, D.G., et al. 1998. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science. 280:295-298.
34. Pratten, J., Foster, S.J., Chan, P.F., Wilson, M., and Nair, S.P. 2001. Staphylococcus aureus accessory regulators: expression within biofilms and effect on adhesion. Microbes. Infect. 3:633-637.
35. Shenkman, B., et al. 2002. Role of agr (RNAIII) in Staphylococcus aureus adherence to fibrinogen, fibronectin, platelets and endothelial cells under static and flow conditions. J. Med. Microbiol. 51:747-754.
36. Vuong, C., Saenz, H.L., Gotz, F., and Otto, M. 2000. Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J. Infect. Dis. 182:1688-1693.
37. Caiazza, N.C., and O'Toole, G.A. 2003. Alpha-toxin is required for biofilm formation by Staphylococcus aureus. J. Bacteriol. 185:3214-3217.
38. Xiong, Y.Q., et al. 2002. Activation and transcriptional interaction between agr RNAII and RNAIII in Staphylococcus aurens in vitro and in an experimental endocarditis model. J. Infect. Dis. 186:668-677.
39. Vuong, C., Gerke, C., Somerville, G.A., Fischer, E.R., and Otto, M. 2003. Quorum-sensing control of biofilm factors in Staphylococcus epidermidis. J. Infect. Dis. 188:706-718.
40. Yarwood, J.M., Barrels, D.J., Volper, E.M., and Greenberg, E.P. 2003. Expression of the accesory gene regulator quorum sensing system in biofilms of Staphylococcus aureus. ASM Conference on Biofilms 2003. Victoria, British Columbia, Canada. 39. (Abstr.)
41. Schwan, W.R., Langhorne, M.H., Ritchie, H.D, and Stover, C.K. 2003. Loss of hemolysin expression in Staphylococcus aureus agr mutants correlates with selective survival during mixed infections in murine abscesses and wounds. FEMS Immunol. Med. Microbiol. 38:23-28.
42. Papakyriacou, H., Vaz, D., Simor, A., Louie, M., and McGavin, M.J. 2000. Molecular analysis of the accessory gene regulator (agr) locus and balance of virulence factor expression in epidemic methicillin-resistant Staphylococcus aureus. J. Infect. Dis. 181:990-1000.
43. Somerville, G.A., et al. 2002. In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence. J. Bacteriol. 184:1430-1437.