Clinical and economic impact of Apligraf® for the treatment of nonhealing venous leg ulcers

International Journal of Dermatology

Volumn 42, Issue 12, 2003, Pages 960-965

  Fivenson, David ^a   Scherschun, Lubomira ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANKLE INJURY; CLINICAL ARTICLE; CLINICAL EXAMINATION; CLINICAL PRACTICE; COMORBIDITY; COMPRESSION THERAPY; CONFERENCE PAPER; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIABETES MELLITUS; DISEASE DURATION; ECONOMIC EVALUATION; FEMALE; FOLLOW UP; FOOT ULCER; GASTROCNEMIUS MUSCLE; HEALTH CARE COST; HUMAN; HYPERTENSION; LEG COMPRESSION; LEG ULCER; MALE; MEDICAL RECORD; OUTCOMES RESEARCH; RETROSPECTIVE STUDY; SKIN ALLOGRAFT; TREATMENT OUTCOME; ULCER HEALING; VENOUS STASIS;

AGED; COLLAGEN; FEMALE; HUMANS; LEG ULCER; MALE; MEDICAL RECORDS; MICHIGAN; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SKIN, ARTIFICIAL; TREATMENT OUTCOME;

EID: 0348163582     PISSN: 00119059     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2003.02039.x     Document Type: Conference Paper

References (33)

1. Dale JJ, Callam MJ, Ruckley CV, et al. Chronic ulcers of the leg: A study of prevalence in a Scottish community. Health Bull (Edinb) 1983; 41: 310-314.
2. Lindholm C, Bjellerup M, Christensen OB, et al. A demographic survey of leg and foot ulcer patients in a defined population. Acta Derm Venereol 1992; 72: 227-230.
3. Coon WW, Willis PW III, Keller JB. Venous thromboembolism and other venous disease in the Tecumseh Community Health Study. Circulation 1973; 48: 839-846.
4. Heit JA, Rooke TW, Silverstein MD, et al. Trends in the incidence of venous stasis syndrome and venous ulcer: A 25-year population-based study. J Vasc Surg 2001; 33: 1022-1027.
5. Nelzén O, Bergqvist D, Lindhagen A, et al. Chronic leg ulcers: An underestimated problem in primary health care among elderly patients. J Epidemiol Community Health 1991; 45: 184-187.
6. Callam MJ, Harper DR, Dale JJ, et al. Chronic ulcer of the leg: Clinical history. BMJ 1987; 294: 1389-1391.
7. Phillips TJ, Dover JS. Continuing medical education: Leg ulcers. J Am Acad Dermatol 1991; 25: 965-987.
8. Young JR. Differential diagnosis of leg ulcers. Cardiovasc Clin 1983; 13: 171-193.
9. Falanga V, Sabolinski M. A bilayered living skin construct (Apligraf®) accelerates complete closure of hard-to-heal venous ulcers. Wound Rep Reg 1999; 7: 201-207.
10. Burnand KG, Whimster I, Browse NL. Pericapillary fibrin in the ulcer-bearing skin of the leg: The cause of lipodermatosclerosis and venous ulceration. Br Med J (Clin Res Ed) 1982; 285: 1071-1072.
11. Browse NL, Burnand KG. The cause of venous ulceration. Lancet 1982; 320: 243-245.
12. Mulder G, Robinson J, Seeley J. Study of sequential compression therapy in the treatment of non-healing chronic venous ulcers. Wounds 1990; 2: 111-115.
13. Sawyer P. New approaches in the therapy of the peripheral vascular ulcer. Angiology 1978; 29: 666-674.
14. O'Donnell TF Jr, Browse NL, Burnand KG, et al. The socioeconomic effects of an iliofemoral venous thrombosis. J Surg Res 1977; 22: 483-488.
15. Olin JW, Beusterien KM, Childs MB, et al. Medical costs of treating venous stasis ulcers: Evidence from a retrospective cohort study. Vasc Med 1999; 4: 1-7.
16. Phillips T, Stanton B, Provan A, et al. A study of the impact of leg ulcers on quality of life: Financial, social, and psychologic implications. J Am Acad Dermatol 1994; 31: 49-53.
17. Falanga V, Margolis D, Alvarez O, et al. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Arch Dermatol 1998; 134: 293-300.
18. Margolis DJ, Cohen JH. Management of chronic venous leg ulcers: A literature-guided approach. Clin Dermatol 1994; 12: 19-26.
19. Phillips TJ. Successful methods of treating leg ulcers the tried and true, plus the novel and new. Postgrad Med 1999; 105: 159-108.
20. Rubin JR, Alexander J, Plecha EJ, et al. Unna's boot vs polyurethane foam dressings for the treatment of venous ulceration. A randomized prospective study. Arch Surg 1990; 125: 489-490.
21. Limova M, Troyer-Caudle J. Controlled, randomized clinical trial of 2 hydrocolloid dressings in the management of venous insufficiency ulcers. J Vasc Nurs 2002; 20: 22-32.
22. Meyer FJ, Burnard KG, Lagattolla NR, et al. Randomized clinical trial comparing the efficacy of two bandaging regimens in the treatment of venous leg ulcers. Br J Surg 2002; 89: 40-44.
23. Mayberry JC, Moneta GL, Taylor LM Jr, et al. Fifteen-year results of ambulatory compression therapy for chronic venous ulcers. Surgery 1991; 109: 575-581.
24. Kiev J, Noyes LD, Rice JC, et al. Patient compliance with fitted compression hosiery monitored by photoplethysmography. Arch Phys Med Rehabil 1990; 71: 376-379.
25. Kiev J, Kerstein MD. Venous insufficiency and graded compression therapy. Wounds 1993; 5: 280-283.
26. Hume M. Venous ulcers, the vascular surgeon, and the Medicare budget. J Vasc Surg 1992; 16: 671-673.
27. Kitahama A, Elliott LF, Kerstein MD, et al. Leg ulcer: Conservative management or surgical treatment? JAMA 1982; 247: 197-199.
28. Turczynski R, Tarpila E. Treatment of leg ulcers with split skin grafts: Early and late results. Scand J Plast Reconstr Surg Hand Surg 1999; 33: 301-305.
29. Eaglstein WH, Falanga V. Chronic wounds. Surg Clin North Am 1997; 77: 689-700.
30. Schonfeld WH, Villa KF, Fastenau JM, et al. An economic assessment of Apligraf (Graftskin) for the treatment of hard-to-heal leg ulcers. Wound Repair Regen 2000; 8: 251-257.
31. Falanga V, Sabolinski ML. Prognostic factors for healing of venous ulcers and diabetic ulcers. Wounds 2000; 12: 42A-46A.
32. Pham HT, Rosenblum BI, Lyons TE, et al. Evaluation of a human skin equivalent for the treatment of diabetic foot ulcers in a prospective, randomized, clinical trial. Wounds 1999; 11: 79-86.
33. Kirsner RS, Fastenau J, Falabella A, et al. Clinical and economic outcomes with graftskin for hard-to-heal venous leg ulcers: A single-center experience. Dermatol Surg 2002; 28: 81-82.