Use of a telemetry system to examine recovery of the cardiovascular system after excitement induced by handling stress in a conscious cynomolgus monkey (Macaca fascicularis)

Journal of Medical Primatology

Volumn 32, Issue 6, 2003, Pages 346-352

  Hassimoto, Masatoshi ^a   Harada, T ^a  

^a MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

Blood pressure; ECG; Hear rate; Recovery; Restraint; Safety pharmacology; Single dose study; Telemetry system

Indexed keywords

SODIUM CHLORIDE;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD PRESSURE; CARDIOVASCULAR PERFORMANCE; CONSCIOUSNESS; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; ELECTROCARDIOGRAM; EXCITEMENT; HEART RATE; IMMOBILIZATION STRESS; IMPLANTATION; MACACA; MALE; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; PULSE RATE; QRS COMPLEX; QT INTERVAL; SAFETY; STRESS; TELEMETRY; TIME;

ANIMALS; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; HANDLING (PSYCHOLOGY); HEART RATE; MACACA FASCICULARIS; TELEMETRY;

ANIMALIA; MACACA; MACACA FASCICULARIS; PRIMATES;

EID: 0348156081     PISSN: 00472565     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-0684.2003.00036.x     Document Type: Article

References (13)

1. Arita M, Kiyosue T, Aomine M, Imanishi S: Nature of 'residual fast channel' dependent action potentials and slow conduction in guinea pig ventricular muscle and its modification by isoproterenol. Am J Cardiol 51:1433-1440, 1983.
2. Brockway B, Hassler C: Cardiovascular measurements in pharmacology and toxicology. In: New Technologies and Concepts for Reducing Drug Toxicities. Salem & Baskin (eds). Boca Raton, FL: CRC Press 109-132, 1992.
3. De Ponti F, Poluzzi E, Montanaro N: Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus. Eur J Clin Pharmacol 57:185 209, 2001.
4. Hashimoto M, Harada T, Ishikawa T, Obata M, Shibutani Y: Investigation on diabetic autonomic neuropathy assessed by power spectral analysis of heart rate variability in WBN/Kob rats. J Electrocardiol 34:243-250, 2001.
5. Hassimoto M, Kuwahara M, Harada T, Kaga N, Obata M, Mochizuki H, Tsubone H: Diurnal variation of the QT interval in rhesus monkeys. Int J Bioelectron 4:281-282, 2002.
6. Hassimoto M, Harada T, Kaga N, Murano H, Obata M: Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG. J Electrocardiol 35:333-342, 2002.
7. ICH Steering Committee: Guideline on safety pharmacology studies for human pharmaceutical (S7A). In: ICH Steering Committee Meeting, San Diego, CA, USA, November, 2000.
8. Jurkiewicz NK, Sanguinetti MC: Rate-dependent prolongation of cardiac action potentials by a methane-sulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circ Res 72:75-83, 1993.
9. Kass RS, Wiegers SE: The ionic basis of concentration-related effects of noradrenaline on the action potential of calf cardiac purkinje fibres. J Physiol 322:541-558, 1982.
10. Matsunaga T, Harada T, Mitsui T, Inokuma M, Hashimoto M, Miyauchi M, Murano H, Shibutani Y: Spectral analysis of circadian rhythms in heart rate variability of dogs. Am J Vet Res 62:37-42, 2001.
11. Peralta AO, John RM, Gaasch WH, Taggart PI, Martin DT, Venditti FJ: The class III antiarrhythmic effect of sotalol exerts a reverse use-dependent positive inotropic effect in the intact canine heart. J Am Coll Cardiol 36:1404-1410, 2000.
12. Tatsumi T, Koto M, Komatsu H, Adachi J: Effects of repeated chair restraint on physiological values in the rhesus monkey (Macaca mulatta). Jikken Dobutsu 39:361-369, 1990.
13. Watanabe H, Watanabe I, Nakai T, Kunimoto S, Masaki R, Kojima T, Saito S, Ozawa Y, Kanmatuse K: Frequency-dependent electrophysiological effects of flecainide, nifekalant and d,l-sotalol on the human atrium. Jpn Circ J 65:1-6, 2001.