LmbJ and LmbIH protein levels correlate with lincomycin production in Streptomyces lincolnensis

Letters in Applied Microbiology

Volumn 37, Issue 6, 2003, Pages 470-474

  Hola, K ^a   Janata, J ^a   Kopecky, J ^a   Spizek, J ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

CalR6 gene; Lincomycin; LmbIH; Secondary metabolism; Streptomyces lincolnensis; TldD PmbA family

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; GENE EXPRESSION; METABOLISM; THIN LAYER CHROMATOGRAPHY;

CALR6 GENE; CATALYTIC FUNCTIONS; LINCOMYCIN; LMBIH; OVERLAPPING GENES; PRODUCTION PHASE; PROTEIN LEVEL; SECONDARY METABOLISM; STREPTOMYCES LINCOLNENSIS; TLDD/PMBA FAMILY;

PROTEINS;

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; LINCOMYCIN; LMBIH PROTEIN; LMBJ PROTEIN; UNCLASSIFIED DRUG;

GENE;

ARTICLE; BACTERIAL GENE; BACTERIAL METABOLISM; BIOSYNTHESIS; CALR6 GENE; GENE EXPRESSION; LMBIH GENE; LMBJ GENE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; STREPTOMYCES; STREPTOMYCES LINCOLNENSIS; THIN LAYER CHROMATOGRAPHY; WESTERN BLOTTING;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOMYCES; STREPTOMYCES LINCOLNENSIS;

EID: 0348147588     PISSN: 02668254     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1472-765X.2003.01432.x     Document Type: Article

References (11)

1. Ahlert, J., Shepard, E., Lomovskaya, N., Zazopoulos, E., Staffa, A., Bachmann, B.O., Huang, K., Fonstein, L. et al. (2002) The calicheamicin gene cluster and its iterative type I enediyne PKS. Science 297, 1173-1176.
2. Chung, S-T.C., Manis, J.J., McWethy, S.J., Patt, T.E., Witz, D.F., Wolf, H.J. and Wovcha, M.G. (1997) Fermentation, biosynthesis, and molecular genetics of lincomycin. In Biotechnology of Industrial Antibiotics ed. Strohl, W.R. pp. 165-186. New York: Dekker.
3. Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., Eiglmeier, K. et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544.
4. Gonzales, J.E. and Miller, T.L. (1985) Lincomycin. In Comprehensive Biotechnology ed. Blanche, H., Drew, S. and Wang, D.I.C. pp. 75-76. Oxford: Pergamon Press.
5. Hopwood, D.A., Bibb, M.J., Chater, K.F., Kieser, T., Bruton, C.J., Lydiate, D.J., Smith, C.P., Ward, J.M. et al. (1985) Genetic Manipulation of Streptomyces: a Laboratory Manual. Norwich: The John Innes Foundation.
6. Janata, J., Najmanova, L., Novotna, J., Hola, K., Felsberg, J. and Spizek, J. (2001) Putative lmbI and lmbH genes form a single lmbIH ORF in Streptomyces lincolnensis type strain ATCC25466. Antonie Van Leeuwenhoek 79, 277-284.
7. Murayama, N., Shimizu, H., Takiguchi, S., Baba, Y., Amino, H., Horiuchi, T., Sekimizu, K. and Miki, T. (1996) Evidence for involvement of Escherichia coli genes pmb A, csr A and a previously unrecognized gene tldD, in the control of DNA gyrase by letD (ccdB) of sex factor F. Journal of Molecular Biology 256, 483-502.
8. Neusser, D., Schmidt, H., Spížek, J., Novotná, J., Peschke, U., Kaschabeck, S., Tichý, P. and Piepersberg, W. (1998) The genes lmb B1 and lmb B2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A. Archives of Microbioogy 169, 322-332.
9. Omura, S., Ikeda, H., Ishikawa, J., Hanamoto, A., Takahashi, C., Shinose, M., Takahashi, Y., Horikawa, H. et al. (2001) Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proceedings of the National Academy of Sciences of the United States of America 98, 12215-12220.
10. Peschke, U., Schmidt, H., Zhang, H.Z. and Piepersberg, W. (1995) Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11. Molecular Microbiology 16, 1137-1156.
11. Redenbach, M., Kieser, H.M., Denapaite, D., Eichner, A., Cullum, J., Kinashi, H. and Hopwood, D.A. (1996) A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome. Molecular Microbiology 21, 77-96.