Effects of MK-801 (dizocilpine) on Brain Cell Membrane Function and Energy Metabolism in Experimental Escherichia coli Meningitis in the Newborn Piglet

Journal of Korean Medical Science

Volumn 18, Issue 2, 2003, Pages 236-241

  Ko, Sun Young ^a   Shim, Jae Won ^c   Kim, Sung Shin ^b   Kim, Mi Jung ^c   Chang, Yun Sil ^c   Park, Won Soon ^b   Shin, Son Moon ^a   Lee, Munhyang ^c  

^a Samsung Advanced Institute of Technology (SAIT)   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Sungkyunkwan Univ Sch of Medicine ^*

Author keywords

Animals, newborn; Brain; Energy metabolism; Excitatory amino acid antagonists; Meningitis, bacterial

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; DIZOCILPINE; GLUTAMIC ACID; LACTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIAL MENINGITIS; BRAIN CELL; CELL FUNCTION; CELL MEMBRANE; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; DRUG EFFECT; ENERGY METABOLISM; ESCHERICHIA COLI; INTRACRANIAL PRESSURE; LEUKOCYTOSIS; LIPID PEROXIDATION; NEUROPROTECTION; NEWBORN DISEASE; NONHUMAN; REVIEW; SWINE;

EID: 0348147399     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.2003.18.2.236     Document Type: Review

References (35)

1. Anderson SG, Giulbert GL. Neonatal Gram negative meningitis. A 10-year review, with reference to outcome and relapse of infection. J Paediatr Child Health 1990; 26: 212-6.
2. de Louvois J. Acute bacterial meningitis in the newborn. J Antimicrob Chemother 1994; 34 (Suppl A): 61-73.
3. Franco SM, Cornelius VE, Andrews BF. Long-term outcome of neonatal meningitis. Am J Dis Child 1992; 146: 567-71.
4. Rothman SM, Olney JW. Glutamate and the pathophysiology of hypoxic ischemic brain damage. Ann Neurol 1986; 19: 105-11.
5. Rothman SM, Olney JW. Excitotoxicity and the NMDA receptor. Trends Neurosci 1987; 10: 299-302.
6. Meldrum B. Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters. Clin Sci 1985; 68: 113-22.
7. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988; 1: 623-34.
8. Spranger M, Krempien S, Schwab S, Maiwald M, Bruno K, Hack W. Excess glutamate in the cerebrospinal fluid in bacterial meningitis. J Neurol Sci 1996; 143: 126-31.
9. Johnson MV. Neurotransmitters an vulnerability of the developing brain. Brain Dev 1995; 17: 301-6.
10. Guerra-Romero L, Tureen JH, Founrier MA, Makrides V, Tauber MG. Amino acids in cerebrospinal and brain interstitial fluid during experimental pneumococcal meningitis. Pediatr Res 1993; 33: 510-3.
11. Perry V, Young RSK, Aquilla WJ, During MJ. Effect of experimental Escherichia coli meningitis on concentrations of excitatory and inhibitory amino acids in the rabbit brain: in vivo microdialysis study. Pediatr Res 1993; 34: 187-91.
12. Leib SL, Kim YS, Ferriero DM, Tauber MG. Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis. J Infect Dis 1996; 173: 166-71.
13. Flecknell PA, Wootton R, John M. Accurate measurement of cerebral energy metabolism in the conscious unrestrained neonatal piglet. Biol Neonate 1982; 41: 221-6.
14. Dobbing J, Sands J. Comparative aspects of the brain growth spurt. Early Hum Dev 1979; 3: 79-83.
15. Weiser JN, Gotschlich EC. Outer membrane protein A (Omp A) contributes to serum resistance and pathogenicity of Escherichia coli K-1. Infect Immun 1991; 59: 2252-8.
16. Chang YS, Park WS, Lee MH, Kim KS, Shin SM, Choi JH. Effect of hyperglycemia on brain cell membrane function and energy metabolism during hypoxia-ischemia in the newborn piglets. Brain Res 1998; 798: 271-80.
17. Chang YS, Park WS, Lee MH, Kim KS, Shin SM, Choi JH. Near infrared spectroscopic monitoring of secondary cerebral energy failure after transient global hypoxia-ischemia in the newborn piglet. Neurol Res 1999; 21: 216-24.
18. Park WS, Chang YS, Lee MH. Effects of induced hyperglycemia on brain cell membrane function and energy metabolism during the early phase of experimental meningitis in newborn piglets. Brain Res 1998; 798: 195-203.
19. Harik SI, Douli GH, Dick APK. Specific ouabain binding to brain microvessels and choroids plexus. J Cereb Blood Flow Metab 1985; 5: 156-60.
20. +-APTase in cortical brain slices in normal Krebs-Ringer phosphate medium at 1 and 10 atm oxygen pressures. J Neurochem 1981; 36: 333-5.
21. Recknagel RO, Glende AE Jr. Spectrophotometric detection of lipid conjugated dienes. Methods Enzymol 1984; 105: 331-7.
22. Lamprecht WA, Stein P, Heinz. Creatine phosphate. In: Bergmeyer HU, ed. Methods of enzymatic analysis. New York: 1974; 4: 1771-81.
23. Volpe JJ. Hypoxic-ischemic encephalopathy: biochemical and physiological aspects, W.B Saunders Company, Neurology of the newborn, fourth Ed. 2001; 217-6.
24. Fridovich I. Biological effects of the superoxide radical. Arch Biochem Biophys 1986; 247: 1-11.
25. Mattson MP. Modification of ion homeostasis by lipid peroxidation: Roles in neuronal degeneration and adaptive plasticity. Trends Neurosci 1998; 21: 53-7.
26. Kennedy MC, Antholine WE, Beinert H. An EPR investigation of the products of the reaction of cytosolic and mitochondrial aconitases with nitric oxide. J Biol Chem 1997; 272: 20340-7.
27. Szabo C, Zingarelli B, Salzman AL. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitirite. Circ Res 1996; 78: 1051-63.
28. Lees GJ. Inhibition of sodium-potassium-ATPase: A potentially ubiquitous mechanism contributing to central nervous system neuropathology. Brain Res Rev 1991; 16: 283-300.
29. Jabaudon D, Scanziani M, Gahwiler BH. Acute decrease in net glutamate uptake during energy deprivation. Proc Natl Acad Sci USA 2000; 97: 5610-5.
30. Bullock R, Zauner A, Woodward JJ, Myseros J, Choi SC, Ward JD, Marmarou A, Young HF. Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg 1998; 89: 507-18.
31. Smith JF, Landing BH. Mechanism of brain damage in H. influenzae meningitis. J Neuropathol Exp Neurol 1960; 19: 248-65.
32. Pfister HW, Borasio GD, Dimagl U, Bauer M, Einhaupl KM. Cerebrovascular complications of bacterial meningitis in adults. Neurology 1992; 42: 1497-504.
33. Forderreuther S, Tatsch K, Einhaupl KM, Pfister HW. Abnormalities of cerebral blood flow in the acute phase of bacterial meningitis in adults. J Neurol 1992; 239: 431-6.
34. Tureen JH, Dworkin RJ, Kennedy SL, Sachdeva M, Sande MA. Loss of cerebrovascular autoregulation in experimental meningitis in rabbits. J Clin Invest 1990; 85: 577-81.
35. Clineschmidt BV, Martin GE, Bunting PR, Papp NL. Central sympathomimetic activity of (+)-5-methyl-10,11-dihydro-5H-dibenzo 〈a,d〉cyclohepten-5, 10-imine (MK801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties. Drug Dev Res 1982; 2: 135-45.