Effect of polyethylene glycols addition in microsphere formulations of cellullose acetate butyrate on efficacy carbamazepine and particles morphology encapsulation;Efeito da adição de polietilenoglicóis nas formulações de microesferas de acetobutirato de celulose sobre a eficiência de encapsulação da carbamazepina e morfologia das partículas

Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

Volumn 38, Issue 2, 2002, Pages 229-236

  Giehl Zanetti, Betina ^a   Soldi, Valdir ^a   Lemos Senna, Elenara ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Carbamazepine; Cellulose acetate butyrate; Emulsion solvent evaporation method; Microspheres; Polyethylene glycol 4000; Polyethylene glyol 1500

Indexed keywords

CARBAMAZEPINE; CELLABURATE; MACROGOL; MICROSPHERE;

ARTICLE; DRUG FORMULATION; DRUG RELEASE; EMULSION; ENCAPSULATION; EVAPORATION; MOLECULAR WEIGHT; PARTICLE SIZE;

EID: 0348078322     PISSN: 15169332     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. ARNAUD, P., BOUÉ, C., CHAUMEIL, C. Cellulose acetate butyrate microparticles for controlled release of carbamazepine. J. Microencapsulation, v. 13, n. 4, p. 407-417, 1996.
2. BRADWAJ, S. B., SHUKLA, A. J., COLLINS, C. C. Effect of varying drug loading on particle size distribution and drug release kinetics of verapamil hydrocloride microspheres prepared with cellulose esters. J. Microencapsulation, v. 12, n. 1, p. 71-81, 1995.
3. BAHL, Y. and SAH, H. Dynamic changes in size distribution of emulsion droplets during ethyl acetate-based microencapsulation process. AAPS Pharm. Sci. Tech., v. 1, n. 1, 2000. Disponível em http://www.pharmascitech. com. Acesso em: 26 março de 2001.
4. DOSHI, D. H., RAVIS, W. R., BETAGERI, G. V. Carbamazepine and polyethylene glycol solid dispersions: Preparations, in vitro dissolution and characterization. Drug Devel. Ind. Pharm., v. 23, n. 12, p. 1167-1176, 1997.
5. EASTMAN Cellulose Esters for Pharmaceutical Drug Delivery. Disponivel em: http://www.eastman.com. Acesso em: dez. 2000.
6. KHAWLA, A. A., CONTRERAS, L. G., LU, D. L. Preparation and evaluation of sustained release AZT-loaded microspheres: Optimization of the release characteristics using response surface methodology. J. Pharm. Sci., v. 85, n. 2, p. 144-149, 1996.
7. KHIDR, S. H., NIAZY,. M. el-SAYED, Y. M. Development and in vitro evaluation sustained release meclofenamic acid microspheres. J. Microencapsulation, v. 15, n. 2, p. 153-62, 1998.
8. KOROLKOVAS, A Dicionàrio Terapéutico Guanabara. Ed. 1998/1999. Rio de Janeiro: Guanabara Koogan, 1998. p. 1.14.
9. REYNOLDS, J. E. F., ed. Martindale. The extra Pharmacopeia. 29 ed. London: The Pharmaceutical Press, 1989. p. 12-21.
10. UNITED STATES PHARMACOPEA. 17 ed. Rockville, 1997. v.1, p. 166-173, 277-288, 714-720, 1585-1595.
11. WADE, A, WELLER, P. Handbook of Pharmaceutical Excipientes. 2. ed. London: The Pharmaceutical Press, 1994. p.355-361.
12. WATTS, P. J., DAVIES, M. C., MELIA, C. D. Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications. Crit. Rev. Ther. Drug Car. Syst., v. 7, n. 3, p. 235-259, 1990.
13. YEH, M. K., JENKINS, P. G., DAVIS, S.S., COOMBES, A G. A. Improving the delivery capacity of microparticle systems using blends of poly (DL-lactide co-glycolide) and poly (ethylene glycol). J. Controlled Release, v. 37, p. 1-9, 1995.
14. YEH, M. K. The stability of insulin in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol. J. Microencapsulation, v. 17, n. 6, p. 743-756, 2000.
15. YUAN, J., WU, S. Comprimidos de liberação controlada via compressão direta. Um estudo de viabilidade usando acetato de celulose e acetobutirato de celulose. Pharm. Technol. Brasil, v. 5, n. 1, p. 34-42, 2001.
16. ZERROUK, N., CHEMTOB, C., ARNAUD, P., TOSCANI, S., DUGUE, J. In vitro and in vivo evaluation of carbamazepine-PEG 6000 solid dispersions. Int. J. Pharm., v. 225, p. 49-62, 2001.