Circadian Gene Expression Regulates Pulsatile Gonadotropin-Releasing Hormone (GnRH) Secretory Patterns in the Hypothalamic GnRH-Secreting GT1-7 Cell Line

Journal of Neuroscience

Volumn 23, Issue 35, 2003, Pages 11202-11213

  Chappell, Patrick E ^a   White, Rachel S ^a   Mellon, Pamela L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Circadian; Clock; GnRH; GT1 7; Pulsatility; Secretion

Indexed keywords

GONADORELIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL LINE; CELL STRAIN GT1-7; CIRCADIAN RHYTHM; CLOCK DELTA19 GENE; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; FIBROBLAST; GENE; GENE EXPRESSION; GONADOTROPIN RELEASE; HORMONE RELEASE; HYPOTHALAMUS; IN VIVO STUDY; LIMB CLOCK GENE; MCRY 1 GENE; MOLECULAR MECHANICS; MOUSE; NEUROSECRETION; NONHUMAN; PRIORITY JOURNAL; PULSATILE DRUG RELEASE; SOMATIC MUTATION; SUPRACHIASMATIC NUCLEUS; VAGINA CYTOLOGY;

EID: 0348010290     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-35-11202.2003     Document Type: Article

References (62)

1. Allen G, Rappe J, Earnest DJ, Cassone VM (2001) Oscillating on borrowed time: diffusible signals from immortalized suprachiasmatic nucleus cells regulate circadian rhythmicity in cultured fibroblasts. J Neurosci 21:7937-7943.
2. Allen GC, Earnest DJ (2002) Real-time analysis of rhythmic gene expression in immortalized suprachiasmatic nucleus cells. NeuroReport 13:2027-2030.
3. Balsalobre A (2002) Clock genes in mammalian peripheral tissues. Cell Tissue Res 309:193-199.
4. Balsalobre A, Damiola F, Schibler U (1998) A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 93:929-937.
5. Balsalobre A, Marcacci L, Schibler U (2000a) Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts. Curr Biol 10:1291-1294.
6. Balsalobre A, Brown SA, Marcacci L, Tronche F, Kellendonk C, Reichardt HM, Schutz G, Schibler U (2000b) Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 289:2344-2347.
7. Beaver LM, Gvakharia BO, Vollintine TS, Hege DM, Stanewsky R, Giebultowicz JM (2002) Loss of circadian clock function decreases reproductive fitness in males of Drosophila melanogaster. Proc Natl Acad Sci USA 99:2134-2139.
8. Brann DW, Mahesh VB (1994) Excitatory amino acids: function and significance in reproduction and neuroendocrine regulation. Front Neuroendocrinol 15:3-49.
9. Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, Simon MC, Takahashi JS, Bradfield CA (2000) Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103:1009-1017.
10. Charles AC, Hales TG (1995) Mechanisms of spontaneous calcium oscillations and action potentials in immortalized hypothalamic (GT1-7) neurons. J Neurophysiol 73:56-64.
11. Cho S, Cho H, Geum D, Kim K (1998) Retinoic acid regulates gonadotropin-releasing hormone (GnRH) release and gene expression in the rat hypothalamic fragments and GT1-1 neuronal cells in vitro. Brain Res Mol Brain Res 54:74-84.
12. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
13. Clarke I, Moore L, Veldhuis J (2002) Intensive direct cavernous sinus sampling identifies high-frequency, nearly random patterns of FSH secretion in ovariectomized ewes: combined appraisal by RIA and bioassay. Endocrinology 143:117-129.
14. Costantin JL, Charles AC (1999) Spontaneous action potentials initiate rhythmic intercellular calcium waves in immortalized hypothalamic (GT1-1) neurons. J Neurophysiol 82:429-435.
15. Costantin JL, Charles AC (2001) Modulation of Ca(2+) signaling by K(+) channels in a hypothalamic neuronal cell line (GT1-1). J Neurophysiol 85:295-304.
16. DeFranco DB, Attardi B, Chandran UR (1994) Glucocorticoid receptor-mediated repression of GnRH gene expression in a hypothalamic GnRH-secreting neuronal cell line. Ann NY Acad Sci 746:473-475.
17. Eraly SA, Mellon PL (1995) Regulation of GnRH transcription by protein kinase C is mediated by evolutionarily conserved, promoter-proximal elements. Mol Endocrinol 9:848-859.
18. Fox SR, Smith MS (1985) Changes in the pulsatile pattern of luteinizing hormone secretion during the rat estrous cycle. Endocrinology 116:1485-1492.
19. Funabashi T, Shinohara K, Mitsushima D, Kimura F (2000) Gonadotropin-releasing hormone exhibits circadian rhythm in phase with arginine-vasopressin in co-cultures of the female rat preoptic area and suprachiasmatic nucleus. J Neuroendocrinol 12:521-528.
20. Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280:1564-1569.
21. Gore AC (1998) Diurnal rhythmicity of gonadotropin-releasing hormone gene expression in the rat. Neuroendocrinology 68:257-263.
22. Gray GD, Soderstein P, Tallentire D, Davidson JM (1978) Effects of lesions in various structures of the suprachiasmatic-preoptic region on LH regulation and sexual behavior in female rats. Neuroendocrinology 25:174-191.
23. Herbison AE (1997) Noradrenergic regulation of cyclic GnRH secretion. Rev Reprod 2:1-6.
24. Herbison AE, Dyer RG (1991) Effect on luteinizing hormone secretion of GABA receptor modulation in the medial preoptic area at the time of the proestrous luteinizing hormone surge. Neuroendocrinology 53:317-320.
25. Herbison AE, Heavens RF, Dyer RG (1989) Microdialysis of rat preoptic area: evidence that noradrenaline (NA) stimulates release of GABA. J Neurosci Methods 29:290.
26. Herzog ED, Takahashi JS, Block GD (1998) Clock controls circadian period in isolated suprachiasmatic nucleus neurons. Nat Neurosci 1:708-713.
27. Herzog ED, Grace MS, Harrer C, Williamson J, Shinohara K, Block GD (2000) The role of Clock in the developmental expression of neuropeptides in the suprachiasmatic nucleus. J Comp Neurol 424:86-98.
28. Hirota T, Okano T, Kokame K, Shirotani-Ikejima H, Miyata T, Fukada Y (2002) Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts. J Biol Chem 277:44244-44251.
29. Honma S, Ikeda M, Abe H, Tanahashi Y, Namihara M, Honma K, Nomura M (1998) Circadian oscillation of BMAL1, a partner of a mammalian clock gene clock, in rat suprachiasmatic nucleus. Biochem Biophys Res Comm 250:83-87.
30. Jin X, Shearman LP, Weaver DR, Zylka MJ, De Vries GJ, Reppert SM (1999) A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell 96:57-68.
31. Jung H, Choe Y, Kim H, Park N, Son GH, Khang I, Kim K (2003) Involvement of CLOCK:BMAL1 heterodimer in serum-responsive mPer1 induction. NeuroReport 14:15-19.
32. Krsmanovic LZ, Stojilkovic SS, Merelli F, Dufour SM, Virmani MA, Catt KJ (1992) Calcium signaling and episodic secretion of gonadotropin-releasing hormone in hypothalamic neurons. Proc Natl Acad Sci USA 89:8462-8466.
33. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193-205.
34. Lee C, Etchegaray JP, Cagampang FR, Loudon AS, Reppert SM (2001) Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107:855-867.
35. Legan SJ, Karsch FJ (1975) A daily signal for the LH surge in the rat. Endocrinology 96:57-62.
36. Legan SJ, Coon GA, Karsch FJ (1975) Role of estrogen as initiator of daily LH surges in the ovariectomized rat. Endocrinology 96:50-56.
37. Loudon ASI, Wayne NL, Krieg R, Iranmanesh A, Veldhuis JD, Menaker M (1994) Ultradian endocrine rhythms are altered by a circadian mutation in the syrian hamster. Endocrinology 135:712-718.
38. Lowrey PL, Shimomura K, Antoch MP, Yamazaki S, Zemenides PD, Ralph MR, Menaker M, Takahashi JS (2000) Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science 288:483-492.
39. Martinez de la Escalera G, Choi ALH, Weiner RI (1992) Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci USA 89:1852-1855.
40. McNamara P, Seo SP, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (2001) Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell 105:877-889.
41. Nitabach MN, Blau J, Holmes TC (2002) Electrical silencing of drosophila pacemaker neurons stops the free-running circadian clock. Cell 109:485-495.
42. Nunemaker CS, DeFazio RA, Geusz ME, Herzog ED, Pitts GR, Moenter SM (2001) Long-term recordings of networks of immortalized GnRH neurons reveal episodic patterns of electrical activity. J Neurophys 86:86-93.
43. Nunemaker CS, Straume M, DeFazio RA, Moenter SM (2003) Gonadotropin-releasing hormone neurons generate interacting rhythms in multiple time domains. Endocrinology 144:823-831.
44. Olcese J, Domagalski R, Bednorz A, Weaver DR, Urbanski HF, Reuss S, Middendorff R (2003) Expression and regulation of mPer1 in immortalized GnRH neurons. NeuroReport 14:613-618.
45. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB (2002) Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109:307-320.
46. Pitts GR, Nunemaker CS, Moenter SM (2001) Cycles of transcription and translation do not comprise the gonadotropin-releasing hormone pulse generator in GT1 cells. Endocrinology 142:1858-1864.
47. Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U, Schibler U (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110:251-260.
48. Sisk CL, Richardson HN, Chappell PE, Levine JE (2001) In vivo gonadotropin-releasing hormone secretion in female rats during peripubertal development and on proestrus. Endocrinology 142:2929-2936.
49. Terasawa E, Keen KL, Mogi K, Claude P (1999) Pulsatile release of luteinizing hormone-releasing hormone (LHRH) in cultured LHRH neurons derived from the embryonic olfactory placode of the rhesus monkey. Endocrinology 140:1432-1441.
50. van der Beek EM, Wiegant VM, van der Donk HA, van den Hurk R, Buijs RM (1993) Lesions of the suprachiasmatic nucleus indicate the presence of a direct vasoactive intestinal polypeptide-containing projection to gonadotrophin-releasing hormone neurons in the female rat. J Neuroendocrinol 5:137-144.
51. van der Beek EM, van Oudheusden HJ, Buijs RM, van der Donk HA, van den Hurk R, Wiegant VM (1994) Preferential induction of c-fos immunoreactivity in vasoactive intestinal polypeptide-innervated gonadotropin-releasing hormone neurons during a steroid-induced luteinizing hormone surge in the female rat. Endocrinology 134:2636-2644.
52. van der Beek EM, Horvath TL, Wiegant VM, van den Hurk R, Buijs RM (1997a) Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin-releasing hormone system: combined tracing and light and electron microscopic immunocytochemical studies. J Comp Neurol 384:569-579.
53. van der Beek EM, Wiegant VM, van Oudheusden HJ, van der Donk HA, van den Hurk R, Buijs RM (1997b) Synaptic contacts between gonadotropin-releasing hormone-containing fibers and neurons in the suprachiasmatic nucleus and perichiasmatic area: an anatomical substrate for feedback regulation? Brain Res 755:101-111.
54. Veldhuis JD, Johnson ML (1986) Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection. Am J Physiol 250:E486-E490.
55. Vitalis EA, Costantin JL, Tsai PS, Sakakibara H, Paruthiyil S, Iiri T, Martini JF, Taga M, Choi AL, Charles AC, Weiner RI (2000) Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing hormone secretion in GT1 cells. Proc Natl Acad Sci USA 97:1861-1866.
56. Weiner RI, Martinez de la Escalera G (1993) Pulsatile release of gonadotrophin releasing hormone (GnRH) is an intrinsic property of GT1 GnRH neuronal cell lines. Hum Reprod 2:13-17.
57. Wetsel WC, Valença MM, Merchenthaler I, Liposits Z, López FJ, Weiner RI, Mellon PL, Negro-Vilar A (1992) Intrinsic pulsatile secretory activity of immortalized LHRH secreting neurons. Proc Natl Acad Sci USA 89:4149-4153.
58. Wetsel WC, Eraly SA, Whyte DB, Mellon PL (1993) Regulation of gonadotropin-releasing hormone by protein kinases A and C in immortalized hypothalamic neurons. Endocrinology 132:2360-2370.
59. Wilsbacher LD, Yamazaki S, Herzog ED, Song EJ, Radcliffe LA, Abe M, Block G, Spitznagel E, Menaker M, Takahashi JS (2002) Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice in vivo. Proc Natl Acad Sci USA 99:489-494.
60. Yagita K, Okamura H (2000) Forskolin induces circadian gene expression of rPerI, rPer2 and dbp in mammalian rat-1 fibroblasts. FEBS Lett 465:79-82.
61. Yagita K, Tamanini F, van Der Horst GT, Okamura H (2001) Molecular mechanisms of the biological clock in cultured fibroblasts. Science 292:278-281.
62. Zylka MJ, Shearman LP, Weaver DR, Reppert SM (1998) Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron 20: 1103-1110.