Mass spectrometric analysis of human transferrin in different body fluids

Clinical Chemistry and Laboratory Medicine

Volumn 41, Issue 12, 2003, Pages 1580-1588

  Kleinert, Peter ^a   Kuster, Thomas ^a   Durka, Silke ^a   Ballhausen, Diana ^a   Bosshard, Nils U ^a   Steinmann, Beat ^a   Hänseler, Edgar ^b   Jaeken, Jaak ^c   Heizmann, Claus W ^a   Troxler, Heinz ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Carbohydrate deficient transferrin; Congenital disorders of glycosylation; Electrospray ionization mass spectrometry; Glycosylation; Transferrin isoform

Indexed keywords

ANTICOAGULANT AGENT; CARBOHYDRATE DEFICIENT TRANSFERRIN; CITRIC ACID; EDETIC ACID; HEPARIN; ISOPROTEIN; OXALIC ACID; TRANSFERRIN;

ALCOHOL CONSUMPTION; ANALYTIC METHOD; ANION EXCHANGE CHROMATOGRAPHY; ANTIBODY AFFINITY; ARTICLE; BLOOD SAMPLING; BODY FLUID; CEREBROSPINAL FLUID; CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1A; CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1B; CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1C; CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1E; CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1F; CONGENITAL DISORDER OF GLYCOSYLATION TYPE 2A; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; IMMUNOASSAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; PLASMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; SERUM; TURBIDIMETRY; ULTRAVIOLET RADIATION;

EID: 0347989232     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2003.241     Document Type: Article

References (27)

1. Apweiler R, Hermjakob H, Sharon N. On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database. Biochim Biophys Acta 1999; 1473: 4-8.
2. Helenius A, Aebi M. Intracellular functions of N-linked glycans. Science 2001; 291:2364-9.
3. Durand G, Seta N. Protein glycosylation and diseases: blood and urinary oligosaccharides as markers for diagnosis and therapeutic monitoring. Clin Chem 2000; 46:795-805.
4. Kishino S, Miyazaki K. Separation methods for glycoprotein analysis and preparation. J Chromatogr B Biomed Sci Appl 1997; 699:371-81.
5. Peter J, Unverzagt C, Engel WD, Renauer D, Seidel C, Hosel W. Identification of carbohydrate deficient transferrin forms by MALDI-TOF mass spectrometry and lectin ELISA. Biochim Biophys Acta 1998; 1380:93-101.
6. Arndt T. Carbohydrate-deficient transferrin as a marker of chronic alcohol abuse: a critical review of preanalysis, analysis, and interpretation. Clin Chem 2001; 47:13-27.
7. Helander A, Eriksson G, Stibler H, Jeppsson JO. Interference of transferrin isoform types with carbohydrate-deficient transferrin quantification in the identification of alcohol abuse. Clin Chem 2001; 47:1225-33.
8. Foo Y, Rosalki SB. Carbohydrate deficient transferrin measurement. Ann Clin Biochem 1998; 35:345-50.
9. Wada Y, Nishikawa A, Okamoto N, Inui K, Tsukamoto H, Okada S, et al. Structure of serum transferrin in carbohydrate-deficient glycoprotein syndrome. Biochem Biophys Res Commun 1992; 189:832-6.
10. Yamashita K, Ohkura T, Ideo H, Ohno K, Kanai M. Electrospray ionization-mass spectrometric analysis of serum transferrin isoforms in patients with carbohydrate-deficient glycoprotein syndrome. J Biochem 1993; 114: 766-9.
11. Bergen HR, Lacey JM, O'Brien JF, Naylor S. Online single-step analysis of blood proteins: the transferrin story. Anal Biochem 2001; 296:122-9.
12. Lacey JM, Bergen HR, Magera MJ, Naylor S, O'Brien JF. Rapid determination of transferrin isoforms by immunoaffinity liquid chromatography and electrospray mass spectrometry. Clin Chem 2001; 47:513-8.
13. Shevchenko A, Wilm M, Vorm O, Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 1996; 68:850-8.
14. Gorg A, Obermaier C, Boguth G, Harder A, Scheibe B, Wildgruber R, et al. The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 2000; 21:1037-53.
15. Rabilloud T. Proteome research: two-dimensional gel electrophoresis and identification methods. Berlin Heidelberg New York: Springer Verlag, 2000.
16. Stibler H. Direct immunofixation after isoelectric focusing. An improved method for identification of cerebrospinal fluid and serum proteins. J Neurol Sci 1979; 42:275-81.
17. De Jong G, Feelders R, Van Noort WL, Van Eijk HG. Transferrin microheterogeneity as a probe in normal and disease states. Glycoconj J 1995; 12:219-26.
18. Keir G, Winchester BG, Clayton P. Carbohydrate-deficient glycoprotein syndromes: inborn errors of protein glycosylation. Ann Clin Biochem 1999; 36:20-36.
19. Jaeken J, Matthijs G. Congenital disorders of glycosylation. Annu Rev Genomics Hum Genet 2001; 2:129-51.
20. Jaeken J, Carchon H. Congenital disorders of glycosylation: the rapidly growing tip of the iceberg. Curr Opin Neurol 2001; 14:811-5.
21. Nihlen U, Montnemery P, Lindholm LH, Lofdahl CG. Increased serum levels of carbohydrate-deficient transferrin in patients with chronic obstructive pulmonary disease. Scand J Clin Lab Invest 2001; 61:341-7.
22. Larsson A, Flodin M, Kollberg H. Increased serum concentrations of carbohydrate-deficient transferrin (CDT) in patients with cystic fibrosis. Ups J Med Sci 1998; 103:231-6.
23. Lipkowski M, Dibbelt L, Seyfarth M. Is there an analytical or diagnostic advantage from including trisialo transferrin into the fraction of carbohydrate-deficient transferrin? Lessons from a comparison of two commercial turbidimetric immunoassays with the carbohydrate-deficient transferrin determination by high-performance liquid chromatography. Clin Biochem 2000; 33:635-41.
24. Musshoff F. Chromatographic methods for the determination of markers of chronic and acute alcohol consumption. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 781:457-80.
25. Dell A, Morris HR. Glycoprotein structure determination by mass spectrometry. Science 2001; 291:2351-6.
26. Hoffmann A, Nimtz M, Getzlaff R, Conradt HS. 'Brain-type' N-glycosylation of asialo-transferrin from human cerebrospinal fluid. FEBS Lett 1995; 359:164-8.
27. Lubke T, Marquardt T, von Figura K, Korner C. A new type of carbohydrate-deficient glycoprotein syndrome due to a decreased import of GDP-fucose into the golgi. J Biol Chem 1999; 274:25986-9.