The Binding of Folic Acid and 5-Methyltetrahydrofolate to Folate-Binding Proteins during Gastric Passage Differs in a Dynamic in Vitro Gastrointestinal Model

Journal of Nutrition

Volumn 134, Issue 1, 2004, Pages 31-37

  Verwei, Miriam ^a,b   Arkbåge, Karin ^c   Mocking, Hans ^a   Havenaar, Robert ^a   Groten, John ^a  

^a TNO   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

5 Methyltetrahydrofolate; Folate binding protein; Folic acid; Gastric passage; Milk products

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; FOLATE BINDING PROTEIN; FOLIC ACID;

ABSORPTION; ARTICLE; DAIRY PRODUCT; DUODENUM; DYNAMICS; FOOD INTAKE; GASTROINTESTINAL TRACT; IN VITRO STUDY; MILK LEVEL; MODEL; NONHUMAN; PROTEIN BINDING; SIMULATION; VITAMIN SUPPLEMENTATION;

EID: 0347986940     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.1.31     Document Type: Article

References (41)

1. MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338: 131-137.
2. Cuskelly, G. J., McNulty, H. & Scott, J. M. (1996) Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects. Lancet 347: 657-659.
3. Boushey, C. J., Beresford, A. A., Omen, G. S. & Motulsky, A. G (1996) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. J. Am. Med. Assoc. 274: 1049-1057.
4. Graham, I. A. & O'Allaghan, P. (2000) The role of folic acid in the prevention of cardiovascular disease. Curr. Opin. Lipidol. 11: 577-587.
5. Giovannucci, E., Stampfer, M. J., Colditz, G. A., Hunter, D. J., Fuchs, C., Rosner, B. A., Speizer, F. E. & Willet, W. C. (1998) Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann. Intern. Med. 129: 517-524.
6. Rampersaud, G. C., Bailey, L. B. & Kauwell, G.P.A. (2002) Relationship of folate to colorectal and cervical cancer: review and recommendations for practitioners. J. Am. Diet. Assoc. 102: 1273-1282.
7. Bailey, L. B., Rampsaud, G. C. & Kauwell, G.P.A. (2003) Folic acid supplements and fortification affect the risk for neural tube defects, vascular disease and cancer: evolving science. J. Nutr. 133: 1961S-1968S.
8. Tamura, T. (1997) Bioavailability of folic acid in fortified foods. Am. J. Clin. Nutr. 66: 1299-1300.
9. Brouwer, I. A., van Dusseldorp, M., West, C. E., Meyboom, S., Thomas, C.M.G., Duran, M., van het Hof, K. H., Eskes, T.K.A.B., Hautvast, J.G.A.J. & Steegers-Theunissen, R.P.M. (1999) Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. J. Nutr. 129: 1135-1139.
10. Konings, E.J.M., Roomans, H.H.S., Dorant, E., Goldbohm, R. A., Saris, W.H.M. & van den Brandt, P. A. (2001) Folate intake of the Dutch population according to newly established liquid chromatography data for foods. Am. J. Clin. Nutr. 73: 765-776.
11. Becker, W. (1994) Dietary habits and nutrient intake in Sweden 1989. Swedish National Food Administration, Livsmedelsverkets förlag, Uppsala, Sweden.
12. Swiatlo, N., O'Conner, D. L., Andrews, J. & Picciano, M. F. (1990) Relative folate bioavailability from diets containing human, bovine and goat milk. J. Nutr. 120: 172-177.
13. Verwei, M., Arkbåge, K., Havenaar, R., van den Berg, H., Witthöft, C. & Schaafsma, G. (2003) Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model. J. Nutr. 133: 2377-2383.
14. Wigertz, K., Hansen, S. I., Hoier-Madsen, M., Holm, J. & Jägerstad, M. (1996) Effect of milk processing on the concentration of folate binding protein (FBP), the folate binding capacity and the retention of 5-methyltetrahydrofolate. Int. J. Food Sci. Nutr. 47: 315-322.
15. Ghitis, J. (1967) The folate binding in milk. Am. J. Clin. Nutr. 20: 1-4.
16. Wagner, C. (1985) Folate binding proteins. Nutr. Rev. 43: 293-299.
17. 12- and folate binding proteins in milk. Br. J. Nutr. 31: 243-257.
18. Tani, M. & Iwai, K. (1984) Some nutritional effects of folate binding protein in bovine milk on the bioavailability of folate to rats. J. Nutr. 114: 778-785.
19. Sethub, J., Arnold, R., Smith, A. & Picciano, M. F. (1984) Milk folate binding protein (FBP): a secretory protein for folate? Nutr. Res. 4: 181-187.
20. Colman, N., Hettiarachchy, N. & Herbert, V. (1981) Detection of a milk factor that facilitates folate uptake by intestinal cells. Science (Washington, DC) 211: 1427-1429.
21. Salter, D. & Blakeborough, P. (1988) Influence of goat's-milk folate-binding protein on transport of 5-methyltetrahydrofolate in neonatal-goat small intestinal brush-border-membrane vesicles. Br. J. Nutr. 59: 497-507.
22. Tani, M., Fushiki, T. & Iwai, K. (1983) Influence of folate binding protein from bovine milk on the absorption of folate in gastrointestinal tract of rat. Biochim. Biophys. Acta 757: 274-281.
23. Said, H. M., Horne, D. W. & Wagner, C. (1986) Effect of human folate binding protein on folate intestinal transport. Arch. Biochem. Biophys. 251: 114-120.
24. Salter, D. N. & Mowlem, A. (1983) Neonatal role of milk folate-binding protein: studies on the course of digestion of goat's milk folate binder in the 6-days old kid. Br. J. Nutr. 50: 589-596.
25. Arkbåge, K., Verwei, M., Havenaar, R. & Witthöft, C. (2003) Folic acid and (6S)-5-methyltetrahydrofolate bioaccessibility decreases after addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model. J. Nutr. 133: 3678-3683.
26. Van den Berg, H., Finglas, P. M. & Bates, C. (1994) FLAIR intercomparison on serum and red cell folate. Int. J. Vitam. Nutr. Res. 64: 288-293.
27. Forssén, K. M., Jägerstad, M. I., Wigertz, K. & Witthöft, C. M. (2000) Folates and dairy products: a critical update. J. Am. Coll. Nutr. 19: 100S-110S.
28. Minekus, M., Marteau, P., Havenaar, R. & Huis in't Veld, J.H.J. (1995) A multicompartmental dynamic computer-controlled model simulating the stomach and small intestine. Alternatives to Laboratory Animals 23: 197-209.
29. Minekus, M. (1998) Development and Validation of a Dynamic Model of the Gastrointestinal Tract. Doctoral thesis, University of Utrecht, Utrecht, Netherlands.
30. Zeijdner, E. E. & Havenaar, R. (2000) The fate of orally administered compounds during passage through the gastrointestinal tract simulated in a dynamic in vitro model (TIM). European Pharmaceutical Contractor, February 2000, pp. 76-81.
31. Høier-Madsen, M., Hansen, S. I. & Holm, J. (1986) Rabbit antibodies against the folate binding protein from cows'milk. Production, characterisation and use for development of an enzyme-linked immunosorbent assay (ELISA). Biosci. Rep. 6: 895-900.
32. Wigertz, K., Svensson, U. K. & Jägerstad, M. (1997) Folate and folate-binding protein content in dairy products. J. Dairy Res. 64: 239-252.
33. Blake, M. S., Johnston, K. H., Russell-Jones, G. J. & Gotschlich, E. C. (1984) A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots. Anal. Biochem. 136: 175-179.
34. Nygren, L., Sternesjö, Å. & Björk, L. (2003) Determination of folate-binding proteins from milk by optical biosensor analysis. Int. Dairy J. 13: 283-290.
35. Salter, D. N., Scott, K. J., Slade, H. & Andrews, P. (1981) The preparation and properties of folate-binding protein from cow's milk. Biochem. J. 193: 469-476.
36. Iwai, K., Tani, M. & Fushiki, T. (1983) Electrophoretic and immunological properties of folate-binding protein isolated from bovine milk. Agric. Biol. Chem. 47: 1523-1530.
37. Anthony, A. C., Utley, P. D., Marcell, P. D. & Kolhouse, J. F. (1982) Isolation, characterization, and comparison of the solubilized particulate and soluble folate binding proteins from human milk. J. Biol. Chem. 257: 10081-10089.
38. Holm, J. & Hansen, S. I. (2001) Binding of radiolabeled folate and 5-methyltetrahydrofolate to cow's milk folate binding protein at pH 7.4 and 5.0. Relationship to concentration and polymerization equilibrium of the purified protein. Biosci. Rep. 21: 733-743.
39. Holm, J. & Hansen, S. I. (2002) Ligand binding characteristics of two molecular forms, one equipped with a hydrophobic glycosyl phosphatidylinositol tail, of the folate binding protein purified from human milk. Biosci. Rep. 22: 455-463.
40. Givas, J. K. & Gutcho, S. (1975) pH dependence of the binding of folates to milk binder in radioassay of folates. Clin. Chem. 21: 427-428.
41. Gregory, J. F., III (1982) Denaturation of the folacin-binding protein in pasteurized milk products. J. Nutr. 112: 1329-1338.