Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction

American Journal of Veterinary Research

Volumn 65, Issue 1, 2004, Pages 80-87

  Deaton, Christopher M ^a   Marlin, David J ^a   Smith, Nicola C ^a   Harris, Pat A ^b   Roberts, Colin A ^c   Schroter, Robert C ^d   Kelly, Frank J ^e  

^a ANIMAL HEALTH TRUST   (United Kingdom)

^b WALTHAM CENTRE FOR PET NUTRITION   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; DEHYDROASCORBIC ACID;

AIRWAY OBSTRUCTION; ARTICLE; BLOOD ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; ERYTHROCYTE; FEMALE; HORSE DISEASE; LEUKOCYTE COUNT; LUNG ALVEOLUS EPITHELIUM; LUNG FLUID; LUNG LAVAGE; MALE; NEUTROPHIL; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; RECURRENT DISEASE; RESPIRATORY TRACT INFLAMMATION;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BRONCHOALVEOLAR LAVAGE FLUID; EPITHELIUM; HORSE DISEASES; HORSES; LUNG; LUNG DISEASES, OBSTRUCTIVE; PNEUMONIA;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 0347917121     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2004.65.80     Document Type: Article

References (35)

1. Bureau F, Bonizzi G, Kirschvink N, et al. Correlation between nuclear factor-kappaB activity in bronchial brushing samples and lung dysfunction in an animal model of asthma. Am J Respir Crit Care Med 2000;161:1314-1321.
2. Lavoie JP, Maghni K, Desnoyers M, et al. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile. Am J Respir Crit Care Med 2001; 164:1410-1413.
3. Art T, Kirschvink N, Smith N, et al. Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction. Equine Vet J 1999; 31:397-401.
4. Deaton CM, Marlin DJ, Smith NC, et al. Antioxidant supplementation and pulmonary function at rest and exercise. Equine Vet J Suppl 2002;34:58-65.
5. Kelly FJ, Mudway I, Krishna MT, et al. The free radical basis of air pollution: focus on ozone. Respir Med 1995;89:647-656.
6. Wiester MJ, Tepper JS, Winsett DW, et al. Adaptation to ozone in rats and its association with ascorbic acid in the lung. Fundam Appl Toxicol 1996;31:56-64.
7. Rumsey SC, Wang Y, Levine M. Vitamin C. In: Papas AM, ed. Antioxidant status, diet, nutrition, and health. London: CRC Press, 1999; 159-187.
8. Mudway IS, Krishna MT, Frew AJ, et al. Compromised concentrations of ascorbate in fluid lining the respiratory tract in human subjects after exposure to ozone. Occup Environ Med 1999; 56:473-481.
9. Thomas EL, Learn DB, Jefferson MM, et al. Superoxide-dependent oxidation of extracellular reducing agents by isolated neutrophils. J Biol Chem 1988;263:2178-2186.
10. Bielory L, Gandhi R. Asthma and vitamin C. Ann Allergy 1994;73:89-96.
11. Schunemann HJ, Freudenheim JL, Grant BJ. Epidemiologic evidence linking antioxidant vitamins to pulmonary function and airway obstruction. Epidemiol Rev 2001;23:248-267.
12. Romieu I, Trenga C. Diet and obstructive lung diseases. Epidemiol Rev 2001;23:268-287.
13. Packer JE, Slater TF, Willson RL. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 1979;278:737-738.
14. Martensson J, Meister A. Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects. Proc Natl Acad Sci U S A 1991;88:4656-4660.
15. Park JB, Levine M. Purification, cloning and expression of dehydroascorbic acid-reducing activity from human neutrophils: identification as glutaredoxin. Biochem J 1996;315:931-938.
16. Winkler BS, Orselli SM, Rex TS. The redox couple between glutathione and ascorbic acid: a chemical and physiological perspective. Free Radic Biol Med 1994;17:333-349.
17. Buffinton GD, Christen S, Peterhans E, et al. Oxidative stress in lungs of mice infected with influenza A virus. Free Radic Res Commun 1992;16:99-110.
18. Rusakow LS, Han J, Hayward MA, et al. Pulmonary oxygen toxicity in mice is characterized by alterations in ascorbate redox status. J Appl Physiol 1995;79:1769-1776.
19. Robinson NE. International Workshop on Equine Chronic Airway Disease. Michigan State University. 16-18 June 2000. Equine Vet J 2001;33:5-19.
20. Marlin DJ, Fenn K, Smith N, et al. Changes in circulatory antioxidant status in horses during prolonged exercise. J Nutr 2002; 132:1622S-1627S.
21. Smith NC, Dunnett M, Mills PC. Simultaneous quantitation of oxidised and reduced glutathione in equine biological fluids by reversed-phase high-performance liquid chromatography using electrochemical detection. J Chromatogr B Biomed Appl 1995; 673:35-41.
22. Kelly FJ, Rodgers W, Handel J, et al. Time course of vitamin E repletion in the premature infant. Br J Nutr 1990; 63:631-638.
23. Young IS, Trimble ER. Measurement of malondialdehyde in plasma by high performance liquid chromatography with fluorimetric detection. Ann Clin Biochem 1991;28:504-508.
24. Rennard SI, Basset G, Lecossier D, et al. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J Appl Physiol 1986;60:532-538.
25. Bigley RH, Stankova L. Uptake and reduction of oxidized and reduced ascorbate by human leukocytes. J Exp Med 1974; 139:1084-1092.
26. Washko PW, Wang Y, Levine M. Ascorbic acid recycling in human neutrophils. J Biol Chem 1993;268:15531-15535.
27. Borsook H, Davenport H, Jeffreys C, et al. The oxidation of ascorbic acid and its reduction in vitro and in vivo. J Biol Chem 1937;177:237-279.
28. Edelman J, Cardozo C, Lesser M. Lipopolysaccharide stimulates alveolar macrophage adherence in vivo and in vitro. Agents Actions 1989;26:287-291.
29. McGowan SE, Parenti CM, Hoidal JR, et al. Ascorbic acid content and accumulation by alveolar macrophages from cigarette smokers and nonsmokers. J Lab Clin Med 1984;104:127-134.
30. Ralston SL, Nockels CF, Squires EL. Differences in diagnostic test results and hematologic data between aged and young horses. Am J Vet Res 1988;49:1387-1392.
31. Martensson J, Han J, Griffith OW, et al. Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs. Proc Natl Acad Sci U S A 1993;90:317-321.
32. Deaton CM, Marlin DJ, Smith NC, et al. Pulmonary bioavailability of ascorbic acid in an ascorbate-synthesising species. Free Radic Res 2003;37:461-467.
33. Rahman I, Morrison D, Donaldson K, et al. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med 1996;154:1055-1060.
34. Joseph BZ, Routes JM, Borish L. Activities of superoxide dismutases and NADPH oxidase in neutrophils obtained from asthmatic and normal donors. Inflammation 1993;17:361-370.
35. Lykkesfeldt J, Loft S, Poulsen HE. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection-are they reliable biomarkers of oxidative stress? Anal Biochem 1995;229:329-335.