Melatonin's growth-inhibitory effect on hepatoma AH 130 in the rat

Cancer Letters

Volumn 125, Issue 1-2, 1998, Pages 51-59

  Cini, Grazia ^a   Coronnello, Marcella ^a   Mini, Enrico ^a   Neri, Bruno ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Hepatoma AH 130; Melatonin; Tumor growth

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; MELATONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASCITES HEPATOMA; CANCER SURVIVAL; CELL COUNT; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; HEPATOMA CELL; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL TIME; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MELATONIN; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0032513085     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)00480-1     Document Type: Article

References (25)

1. Georgiuou E. Uber die natur und die pathogenese der Krebstumoren, radiale heilung des Krebses bei weien mausen. Zeitschrift Krebsforschung. 38:1929;562-579.
2. Lapin V. Pineal gland and malignancy. Osterreichische Zietschrift Onkologie. 3:1976;51-68.
3. Zachary I., Woll P.J., Rozengurt A. A role for neuropeptides in the control of cell proliferation. Dev. Biol. 124:1987;295-308.
4. Hill S.M., Blask D.E. Effects of the pineal hormone on the proliferation and morphological characteristics of human breast cancer (MCF-7) in culture. Cancer Res. 48:1988;6121-6126.
5. Tan D., Poeggeler B., Reiter R.J., Chen L., Manchester L.C., Barlow-Walden L.R. The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo. Cancer Lett. 70:1993;65-71.
6. D.E. Blask, Melatonin in oncology, in: H.S. Yu, R.J. Reiter (Eds.), Melatonin: Biosynthesis, Physiological Effects and Clinical Applications, CRC Press, Boca Raton, FL, 1993, pp. 448-470.
7. Regelson W., Pierpaoli W. Melatonin: a rediscovered antitumor hormone? Its relation to surface receptors, sex steroid metabolism, immunologic response and chronobiologic factors in tumor growth and therapy. Cancer Invest. 5:1987;379-385.
8. D.E. Blask, The pineal: an oncostatic gland?, in: R.J. Reiter (Ed.), The Pineal Gland, Raven Press, New York, 1984, pp. 253-284.
9. Sànchez-Barcelò E.J., Mediavilla M.D., Tucker H.A. Influence of melatonin on mammary gland growth: in vivo and in vitro studies. Proc. Soc. Exp. Biol. Med. 194:1990;103-111.
10. B. Stankov, F. Fraschini, R.J. Reiter, The melatonin receptors: distribution, biochemistry and pharmacology, in: H.S. Yu, R.J. Reiter (Eds.), Melatonin: Biosynthesis, Physiological Effects and Clinical Applications, CRC Press, Boca Raton, FL, 1993, pp. 155-186.
11. Neri B., Brocchi A., Carossino A.M., Cini-Neri G., Tommasi M.S., Cagnoni M. Effects of melatonin administration on cytokine production in patients with advanced solid tumors. Oncol. Rep. 2:1995;45-47.
12. D.E. Blask, S.M. Hill, Melatonin and cancer: basic and clinical aspects, in: A. Miles, D.R.S. Philbrick, C. Thompson (Eds.), Melatonin Clinical Perspectives, Oxford Medical Publications, University Press, New York, 1988, pp. 128-173.
13. D.E. Blask, The emerging role of the pineal gland and melatonin in oncogenesis, in: B.W. Wilson, R.G. Stevens, L.E. Anderson (Eds.), Extremely Low Frequency Electromagnetic Fields: The Question of the Cancer, Battelle Press, Columbus, OH, 1990, pp. 319-333.
14. Subramanian A., Kothari L. Melatonin, a suppressor of spontaneous murine mammary tumors. J. Pineal Res. 10:1991;136-141.
15. Tessitore L., Bonelli G., Baccino F.M. Early development of protein metabolic perturbations in the liver and skeletal muscle of tumor-bearing rats. Biochem. J. 241:1987;153-158.
16. Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:1958;457-481.
17. Gehan E.A. A generalized Wilcoxon test for comparing arbitrarily single-censored samples. Biometrika. 52:1965;203-223.
18. Gehan E.A. A generalized Wilcoxon test for doubly-censored data. Biometrika. 52:1965;650-653.
19. Pinski J., Schally A.V., Groot K., Halmos G., Szepeshazi K., Zarandi M., Armatis P. Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. J. Natl. Cancer Inst. 87:1995;1787-1791.
20. Fried J., Perez A.G., Clarkson B.D. Rapid hypotonic method for flow cytofluorometry of monolayer cell cultures. Some pitfalls in staining and data analysis. J. Histochem. Cytochem. 26:1978;921-933.
21. Sgonc R., Boeck G., Dietrich H., Gruber J., Recheis H., Wick G. Simultaneous determination of cell surface antigens and apoptosis. Trends Genet. 10:1994;41-42.
22. Lapin V., Ebels I. Effects of some low molecular weight sheep pineal fractions and melatonin on different tumors in rats and mice. Oncology. 33:1976;110-119.
23. Lapin V., Erwein A. Effects of growing tumors on pineal melatonin levels in male rats. J. Neural. Transm. 52:1981;123-131.
24. Cos S., Recio J., Sànchez-Barcelò E.J. Modulation of the cell cycle time of MCF-7 human breast cancer cells by melatonin. Life Sci. 58:1996;811-816.
25. Vijayalaxmi, Reiter R.J., Leal B.Z., Meltz M.L. Effect of melatonin on mitotic and proliferation indices, and sister chromatid exchange in human blood lymphocytes. Mutat. Res. 351:1996;187-192.