T-Cell Anergy: From Phenotype to Genotype and Back

Immunologic Research

Volumn 28, Issue 3, 2003, Pages 255-264

  Seroogy, Christine M ^a   Fathman, C Garrison ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anergy; Soluble peptide; Superantigens; T lymphocytes; Tolerance

Indexed keywords

BROXURIDINE; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CBL PROTEIN; CD4 ANTIGEN; CD53 ANTIGEN; CELL NUCLEUS RECEPTOR; CYTOCHROME C; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; LYMPHOTACTIN; NUCLEAR RECEPTOR RELATED FACTOR 2; PROTEIN P27; RAP PROTEIN; SMAD2 PROTEIN; SMAD4 PROTEIN; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL DIVISION; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CLONAL ANERGY; CROSS LINKING; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVITY; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE ISOLATION; GENE SEQUENCE; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE CLONE; LYMPHOID TISSUE; NONHUMAN; NORTHERN BLOTTING; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TRANSGENIC MOUSE; UPREGULATION; ZINC FINGER MOTIF;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; CLONAL ANERGY; GENOTYPE; MICE; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 0347756795     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:28:3:255     Document Type: Review

References (32)

1. Staveley-O'Carroll K, Sotomayer E, Montgomery J, et al.: Induction of antigen-specific T cell anergy: An early event in the course of tumor progression. Proc Natl Acad Sci USA 1998;95(3):1178-1183.
2. Dresser DW: Effectiveness of lipid and lipidophilic substances as adjuvants. Nature 1961;191:1169.
3. Blaha P, Bigenzahn S, Koporc Z, et al.: The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 2002.
4. Telander DG, Malvey EN, Mueller DL: Evidence for repression of IL-2 gene activation in anergic T cells. J Immunol 1999;162(3): 460-1465.
5. Cho EA, Riley MP, Sillman AL, et al.: Altered protein tyrosinephosphorylation in anergic Th1 cells. J Immunol 1993;151(1):20-28.
6. Pape KA, Merica MP, Sillman AL, et al.: Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral tolerance. J Immunol 1998;160(10):4719-4729.
7. Tanchot C, Barber DL, Chiodetti L, et al.: Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation. J Immunol 2001;(4):2030-2039.
8. Swain SL: Generation and in vivo persistence of polarized Th1 and Th2 memory cells. Immunity 1994;1(7):543-552.
9. Gavin MA, Clarke SR, Negrou E, et al.: Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 2002;3(1):33-41.
10. Healy JI, Dolmetsch RE, Lewis RS, et al.: Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes. Novartis Found Symp 1998;215:137-144; discussion 144-145, 186-190.
11. Su B, Jacinto E, Hibi M, et al.: JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994;77(5):727-736.
12. Boussiotis VA, Freeman GJ, Berezovskaya A, et al.: Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rapl. Science 1997;278(5335):124-128.
13. Sebzda E, Bracke M, Tugal T, et al.: RaplA positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling. Nat Immunol 2002;3(3):251-258.
14. Sundstedt A, Dohlsten M: In vivo anergized CD4+ T cells have defective expression and function of the activating protein-1 transcription factor. J Immunol 1998;161(11):5930-5936.
15. Kang SM, Beverly B, Tran AC, et al.: Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science 1992;257(5073):1134-1138.
16. Powell JD, Bruniquel D, Schwartz RH: TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27(Kip1). Eur J Immunol 2001;31(12):3737-3746.
17. Wells AD, Walsh MC, Sankaran D, et al.: T cell effector function and anergy avoidance are quantitatively linked to cell division. J Immunol 2000;165(5):2432-2443.
18. Wells AD, Walsh MC, Bluestone JA, et al.: Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest 2001;108(6):895-903.
19. Krummel MF, Allison JP: CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 1996;183(6):2533-2540.
20. Greenwald RJ, Boussiotis VA, Lorsbach RB, et al.: CTLA-4 regulates induction of anergy in vivo. Immunity 2001;14(2):145-155.
21. Boussiotis VA, Freeman GJ, Taylor PA, et al.: p27kipl functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat Med 2000;6(3):290-297.
22. Tzachanis D, Freeman GJ, Hirano N, et al.: Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol 2001;2(12):1174-1182.
23. Yoshida Y, Tanaka S, Umemori H, et al.: Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 2000;103(7):1085-1097.
24. Yamashiro H, Odani Y, Hozumi N, et al.: Hierarchical signaling thresholds determine the fates of naive T cells: partial priming leads naïve T cells to unresponsiveness. Biochem Biophys Res Commun 2002;299(1):148-154.
25. Korthauer U, Nagel W, Davis EM, et al.: Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. J Immunol 2000;164(1): 308-318.
26. Macian F, Garcia-Cozar F, Im SH, et al.: Transcriptional mechanisms underlying lymphocyte tolerance. Cell 2002;109(6):719-731.
27. Cerdan C, Devilard E, Xerri L, et al.: The C-class chemokine lymphotactin costimulates the apoptosis of human CD4(+) T cells. Blood 2001;97(8):2205-2212.
28. Kurt RA, Bauck M, Harma S, et al.: Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(1o) cells in vitro and in vivo. Cell Immunol 2001;209(2):83-88.
29. Bachmaier K, Krawczyk C, Kozieradzki I, et al.: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cb1-b. Nature 2000;403(6766):211-216.
30. Zhang J, Bardos T, Li D, et al.: Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cb1-b for ubiquitination. J Immunol 2002;169(5):2236-2240.
31. Amsen D, Revilla Calvoe C, Osborne BA, et al.: Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes. Proc Natl Acad Sci USA 1999;96(2):622-627.
32. Anandasabapathy N, Ford G, Bloom D, et al.: GRAIL: An E3 Ubiquitin Ligase that Inhibits Cytokine Gene Transcription Is Expressed in Anergic CD4+ T Cells. Immunity 2003;18:1-20.