Solid-phase synthesis of 2-substituted 4-amino-7-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidines

Molecular Diversity

Volumn 6, Issue 2, 2003, Pages 85-92

  Falcó, José L ^a   Borrell, José I ^a   Teixidó, Jordi ^a  

^a INSTITUT QUÍMIC DE SARRIÀ   (Spain)

Author keywords

Knoevenagel reaction; Michael reaction; Pyrido 2,3 d pyrimidines; Solid phase synthesis

Indexed keywords

4 AMINO 7 OXO 5,6,7,8 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; 4 HYDROXYBENZALDEHYDE; ALDEHYDE; AMIDINE; ESTER DERIVATIVE; MALONONITRILE; METHYLMALONIC ACID; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; RESIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; CYCLOADDITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SOLID STATE; STEREOCHEMISTRY; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; PYRIDONES; PYRIMIDINES;

EID: 0347719206     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MODI.0000006835.60273.b3     Document Type: Article

References (10)

1. (a) Victory, P. and Borrell, J. I., '6-Alkoxy-5-cyano-3,4-dihydro-2-pyridones as starting materials for the synthesis of heterocycles', In Menon, J. (ed.), Trends in Heterocyclic Chemistry, Vol. 3, Council of Scientific Research Integration, Trivandrum, India, 1993, pp. 235-247 and references therein.
2. (b) Borrell, J. I., Tèixidó, J., Matallana, J. L., Martínez-Teipel, B., Colominas, C., Costa, M., Balcells, M., Schuler, E. and Castillo, M. J., Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), J. Med. Chem., 44 (2001) 2366-2369.
3. (a) Terrett, N. K., Gardner, M., Gordon, D. W., Kobylecki, and R. J. and Steele, J., Combinatorial synthesis - The design of compound libraries and their application to drug discovery, Tetrahedron, 51 (1995) 8135-8173.
4. (b) Dearden, J. C. and Leak, R., Rational drug design: Combinatorial chemistry, QSAR and molecular modelling, Pham. Pharmacol. Commu., 4 (1998) 137-138.
5. (c) Appell, K., Baldwin, J. J. and Egan, W. J., Combinatorial chemistry and high-throughput screening in drug discovery and development Separation Sci. Technol., 3 (2001) 23-56.
6. (a) Obrecht, D. and Villalgordo, J. M., Solid-supported Combinatorial and Parallel Synthesis of Small-molecular-weight Compound Libraries, Pergamon, Oxford, 1998.
7. (b) Bräse, S. and Dahmen S., 'Linkers for Solid-phase Synthesis', In Nicolau, K. C., Hanko, R. and Hartwig, W. (eds.), Handbook of Combinatorial Chemistry, Wiley-VCH Verlag, Weinheim, 2002, pp. 59-153.
8. (a) Eglen, R. M., Schneider, G. and Bohm, H. J., High-throughput screening and virtual screening: Entry points to drug discovery, Methods Princ. Med. Chem., 10 (2000) 1-14.
9. (b) Appell, K., Baldwin, J. J. and Egan, W. J., Combinatorial chemistry and high-throughput screening in drug discovery and development, Separation Sci. Technol., 3 (2001) 23-56.
10. 2Et, J. Am. Chem. Soc., 66 (1944) 1286-1288.