Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)

Journal of Medicinal Chemistry

Volumn 44, Issue 14, 2001, Pages 2366-2369

  Borrell, J I ^a   Teixido J ^a   Matallana, J L ^a   Martinez Teipel B ^a   Colominas, C ^a   Costa, M ^a   Balcells, M ^a   Schuler, E ^a   Castillo, M J ^a  

^a INSTITUT QUÍMIC DE SARRIÀ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BENZOIC ACID DERIVATIVE; CARBONYL DERIVATIVE; FOLIC ACID DERIVATIVE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; RIBONUCLEOTIDE;

ARTICLE; DOSE RESPONSE; HUMAN; HUMAN CELL; MOLECULAR MODEL; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; HUMANS; HYDROXYMETHYL AND FORMYL TRANSFERASES; MODELS, MOLECULAR; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; RIBONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATES; TUMOR CELLS, CULTURED;

EID: 0035811448     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990411u     Document Type: Article

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