Hemostatic activation under anticoagulant treatment: A comparison of unfractionated heparin vs. nadroparin in the treatment of proximal deep vein thrombosis

Thrombosis and Haemostasis

Volumn 82, Issue 4, 1999, Pages 1227-1231

  Stricker, H ^a,b   Marchetti, O ^a   Haeberli, A ^c   Mombelli, G ^a  

^a Ospedale Regionale Locarno   (Switzerland)

^b Ospedale Regionale di Locarno   (Switzerland)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; D DIMER; FIBRIN; HEPARIN; NADROPARIN; PHENPROCOUMON;

ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG BLOOD LEVEL; FEMALE; FIBRIN FORMATION; FIBRINOLYSIS; HEMOSTASIS; HUMAN; INJECTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PHLEBOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; ULTRASOUND;

EID: 0032852661     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614365     Document Type: Article

References (25)

1. Hirsh J, Fuster V. Guide to anticoagulant therapy. Part 1: Heparin. Circulation 1994; 89: 1449-68.
2. Raschke RA, Reilly BM, Guidry JR, Fontana JR, Srinivas S. The weight-based heparin dosing nomogram compared with a "standard care" nomogram. Ann Intern Med 1993; 119: 874-81.
3. Charbonnier BA, Fiessinger JN, Banga JD, Wenzel E, d'Azemar P, Sagnard L. Comparison of a once daily with a twice daily subcutaneous low molecular weight heparin regimen in the treatment of deep vein thrombosis. Thromb Haemost 1998; 79: 897-901.
4. The DVTENOX Study Group. Markers of hemostatic system activation in acute deep venous thrombosis-evolution during the first days of heparin treatment. Thromb Haemost 1993; 70: 909-14.
5. Herren T, Stricker H, Haeberli A, Do DD, Straub PW. Fibrin formation and degradation in patients with arteriosclerotic disease. Circulation 1994; 90: 2679-86.
6. Marder VJ, Soulen RL, Atichartakran V, Budzynski AZ, Parulekar S, Edward KN, Zahavi J, Algazy KM: Quantitative venographic assessment of deep venous thrombosis in the evaluation of streptokinase and heparin therapy. J Lab Clin Med 1977; 89: 1018-29.
7. Granger CB, Becker R, Tracy RP, Califf RM, Topol EJ, Pieper KS, Ross AM, Roth S, Labrew C, Bovill EG. Thrombin generation, inhibition and clinical outcomes in patients with acute myocardial infarction treated with thrombolytic therapy and heparin: results from the GUSTO-I Trial. J Am Coll Cardiol 1998; 31: 497-505.
8. Hull RD, Raskob GE, Brant RF, Pineo GF, Valentine KA. The importance of initial heparin treatment on long-term clinical outcomes of antithrombotic therapy. Arch Intern Med 1997; 157: 2317-21.
9. Hull RD, Raskob GE, Brant RF, Pineo GF, Valentine KA. Relation between the time to achieve the lower limit of the aPTT therapeutic range and recurrent venous thromboembolism during heparin treatment for deep vein thrombosis. Arch Intern Med 1997; 157: 2562-8.
10. Hirsh J. Heparin. New Engl J Med 1991; 324: 1565-74.
11. Bauer KA. Laboratory markers of coagulation activation. Arch Pathol Lab Med 1993; 117: 71-7.
12. Harenberg J, Huck K, Bratsch H, Stehle G, Dempfle CE, Mall K, Blauth M, Usadel KH, Heene DL. Therapeutic application of subcutaneous low molecular weight heparin in acute venous thrombosis. Haemostasis 1990; 20(suppl 1): 205-19.
13. Agnelli G, Iorio A, Renga C, Boschetti E, Nenci GG, Ofosu FA, Hirsh J. Prolonged antithrombin activity of low-molecular-weight heparins. Circulation 1995; 92: 2819-24.
14. Mismetti P, Laporte-Simitsidis S, Navarro C, Sié P, d'Azemar P, Necciari J, Duret JP, Gaud C, Decousus H, Boneu B. Aging and venous thromboembolism influence the pharmacodynamics of the anti-factor Xa and antithrombin activities of a low molecular weight heparin (Nadroparin). Thromb Haemost 1998; 79: 1162-5.
15. de Groot M, Büller HR, ten Cate JW, van Marwijk Kooy M. Use of a heparin nomogram for treatment of patients with venous thromboembolism in a community hospital. Thromb Haemost 1998; 80: 70-3.
16. Lopaciuk S, Meissner J, Filipecki S, Zawilska K, Sowier J, Cielelski L, Bielawiec M, Glowinski S, Czestochowska E. Subcutaneous low molecular weight heparin versus subcutaneous unfractionated heparin in the treatment of deep vein thrombosis. Thromb Haemost 1992; 68: 14-8.
17. Simonneau G, Charbonnier B, Decousus H, Planchon B, Ninet J, Sie P, Silsiguen M, Combe S. Subcutaneous low molecular weight heparin compared with continuous intravenous unfractionated heparin in the treatment of proximal deep vein thrombosis. Arch Intern Med 1993; 153: 1541-46.
18. Lindmarker P, Holmström M, Granquist S, Johnsson H, Lockner D. Comparison of once daily subcutaneous Fragmin with continuous intravenous unfractionated heparin in the treatment of deep vein thrombosis. Thromb Haemost 1994; 72: 186-90.
19. Koopman MMW, Prandoni P, Piovella F, Ockelford PA, Brandjes DPM, van der Meer J, Gallus AS, Simonneau G, Chesterman CH, Prins MH, Bossuyt PMM, de Haes H, van den Belt AGM, Sagnard L, d'Azemar P, Büller M on the behalf of the TASMAN study group. Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low molecular weight heparin administered at home. New Engl J Med 1996; 334: 682-7.
20. Gunnarsson PS, Sawyer WT, Montague D, Williams ML, Dupuis RE, Caaiola SM. Appropriate use of heparin. Empiric vs nomogram-based dosing. Arch Intern Med 1995; 155: 526-32.
21. Raschke RA, Gollihare B, Peirce JC. The effectiveness of implementing the weight-based heparin nomogram as a practice guideline. Arch Intern Med 1996; 156: 1645-49.
22. Hollingsworth JA, Rowe BH, Brisebois FJ, Thompson PR, Fabris LM. The successful application of a heparin nomogram in a community hospital. Arch Intern Med 1995; 155: 2095-100.
23. Leizorovicz A, Simonneau G, Decousus H, Boissel JP. Comparison of efficacy and safety of low molecular weight heparins and unfractionated heparin in initial treatment of deep venous thrombosis: a meta-analysis. BMJ 1994; 309: 299-304.
24. Lensing AWA, Prins MH, Davidson BL, Hirsh J. Treatment of deep venous thrombosis with low molecular weight heparins. Arch Intern Med 1995; 155: 601-7.
25. Siragusa S, Cosmi B, Piovella F, Hirsh J, Ginsberg JS. Low molecular weight heparins and unfractionated heparin in the treatment of patients with acute venous thromboembolism: Results of a meta-analysis. Am J Med 1996; 100: 269-77.