Convenient high yield and stereoselective synthesis of O-glycopeptides using N-α-Fmoc-Tyr/Ser[β-D-Glc(OAc)4]OPfp generated in solution

Tetrahedron Letters

Volumn 45, Issue 2, 2004, Pages 355-358

  Gangadhar, Beechanahalli P ^a   Jois, Seetharama D S ^b   Balasubramaniam, Ambikaipakan ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

NMR; O Glycopeptides; Solid phase synthesis; Stereoselective

Indexed keywords

GLYCOPEPTIDE; PEPTIDE; RESIN;

ARTICLE; PROTEIN GLYCOSYLATION; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TARGETING; QUANTUM YIELD; ROOM TEMPERATURE; SOLUTION AND SOLUBILITY; STEREOCHEMISTRY; SYNTHESIS;

EID: 0347627367     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.10.178     Document Type: Article

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13. 4, evaporated and the residues was dissolved in DMF (10 mL) and used in the next step without further purification.
14. 4]-OPfp}.
15. 2O. Gradients: Figure 1A: 0-70% Buffer Y in Buffer X in 60 min; Figure 1B: 0-15% Buffer Y in Buffer Z in 40 min; Figure 1C: 0-60% Buffer Y in Buffer X in 60 min; Figure 1D: 0-60% Buffer Y in Buffer X in 60 min.