The Effects of Systemic Magnesium Sulfate Infusion on Brain Magnesium Concentrations and Energy State during Hypoxia-Ischemia in Newborn Miniswine

Pediatric Research

Volumn 55, Issue 1, 2004, Pages 93-100

  Gee II, Jerry B ^a   Corbett, Ronald J T ^a   Perlman, Jeffrey ^a   Laptook, Abbot R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM; MAGNESIUM SULFATE; SODIUM SULFATE;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN LEVEL; BRAIN METABOLISM; CELL PH; CONTROLLED STUDY; MAGNESIUM BLOOD LEVEL; MICRODIALYSIS; NERVE INJURY; NEUROPROTECTION; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SWINE;

ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; BRAIN; CARBON DIOXIDE; ENERGY METABOLISM; HYDROGEN-ION CONCENTRATION; HYPOXIA-ISCHEMIA, BRAIN; MAGNESIUM; MAGNESIUM SULFATE; MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN; PHOSPHORYLATION; SWINE; SWINE, MINIATURE;

EID: 0347623208     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000099771.39629.E5     Document Type: Article

References (48)

1. Nowak L, Bogestovski P, Ascher P, Herbet A, Prochiantz A 1984 Magnesium gates glutamate-activated channels in mouse central neurons. Nature 307:462-465
2. Lipton SA, Rosenberg PA 1994 Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613-622
3. Hagberg H, Lehmann A, Sandberg M, Nystrom B, Jacobson I, Hamberger A 1985 Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments. J Cereb Blood Flow Metab 5:413-419
4. Rasch DK, Huber P, Richardson CJ, L'Hommedieu CS, Nelson TE, Reddi R 1982 Neurobehavioral effects of neonatal hypermagnesemia. J Pediatr 100:272-276
5. Stone SR, Pritchard JA 1970 Effect of maternally administered magnesium sulfate on the neonate. Obstet Gynecol 35:574-577
6. Green KW, Key TC, Coen R, Resnik R 1983 The effects of maternally administered magnesium sulfate on the neonate. Am J Obstet Gynecol 146:29-33
7. Cunningham FG, MacDonald PC, Grant NF 1989 Hypertensive disorders in pregnancy. In: Cunningham FG, MacDonald PC, Gant NF (eds) Williams Obstetrics, 18th Ed. Appleton and Lange, Norwalk, CT, pp 653-694
8. Hallak M, Cotton DB 1993 Transfer of maternally administered magnesium sulfate into the fetal compartment of the rat: assessment of amniotic fluid, blood, and brain concentrations. J Obstet Gynecol 169:427-431
9. 4 infusions in miniswine. Pediatr Res 46:281-286
10. Iseri LT, French JH 1984 Magnesium: nature's physiologic calcium blocker. Am Heart J 108:188-193
11. LeBlanc MH, Farias LA, Markov AK, Evans OB, Smith B, Smith EE, Brown EG 1991 Fructose-1,6-diphosphate, when given five minutes after injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig. Biol Neonate 59:98-108
12. 1H nuclear magnetic resonance spectroscopy. J Cereb Blood Flow Metab 13:235-246
13. 31P NMR. Neuroreport 8:287-291
14. Corbett RJT, Laptook AR, Nunnally RL 1987 The use of the chemical shift of the phosphomonoester P-31 magnetic resonance peak for the determination of intracellular pH in the brains of neonates. Neurology 37:1771-1779
15. Corbett RJT, Laptook AR, Ruley JI, Garcia D 1991 The effect of age on glucose modulated cerebral agonal glycolytic rates measured in-vivo by 1H NMR spectroscopy. Pediatr Res 30:579-586
16. Corbett R, Laptook A, Kim B, Tollefsbol G, Silmon S, Garcia D 1999 Maturational changes in cerebral lactate and acid clearance following ischemia measured in vivo using magnetic resonance spectroscopy and microdialysis. Brain Res Dev Brain Res 113:37-46
17. Laptook AR, Peterson J, Porter AM 1987 Cerebral lactic acid delivery and uptake during and after ischemia in the piglet. Neurology 37:1549-1552
18. Rivera LI, Gootman PM, Brust M, Condemi G, Hundley BH, Lin RH, Cohen HL, Gandhi MR, Altura BT, Gootman N 1990 Unusual observations on hypermagnesemic levels and cardiorespiratory effects in neonatal swine. Magnes Trace Elem 9:124-131
19. Caspi J, Coles JG, Benson LN, Herman SL, Augustine J, Wilson GJ 1994 Dose related effects of magnesium on myocardial function in the neonate. Hypertension 23:174-178
20. James MFM, Cork RC, Dennett JE 1987 Cardiovascular effects of magnesium sulphate in the baboon. Magnesium 6:314-324
21. Kim C-R, Oh W, Stonestreet BS 1997 Magnesium is a cerebrovasodilator in newborn piglets. Am J Physiol 272:H511-H516
22. Günzel D, Schlue W-R 1996 Sodium-magnesium antiport in Retzius neurones of the leech Hirudo medicinalis. J Physiol 491:595-608
23. Kato H, Gotoh H, Kajikawa M, Suto K 1998 Depolarization triggers intracellular magnesium surge in cultured dorsal root ganglion neurons. Brain Res 779:329-333
24. 2+] following human focal cerebral ischemia. Neurology 43:1577-1581
25. 31P-nuclear magnetic resonance spectra. J Neurochem 53:331-334
26. Romani A, Scarpa A 1992 Regulation of cell magnesium. Arch Biochem Biophys 298:1-12
27. 2+ increase during depolarization in cultured neurons. Brain Res 828:163-168
28. +-dependent protein kinase C pathways. J Biol Chem 271:24353-24358
29. 2+ signaling in single human tracheal gland cells. Biochem Biophys Res Commun 227:743-749
30. Gaeda M, Singh J, Domschke W, Mooren F Ch, Wisdom DM 1996 Secretagogueevoked mobilization of magnesium in mouse pancreatic acini. J Physiol 493:90-91
31. 2+ in cultured cortical neurons. Neuron 11:751-757
32. 2+ efflux in rat forebrain neurons in culture. J Physiol 492:3:641-657
33. Andiné P, Sandberg M, Bågenholm R, Lehmann A, Hagberg H 1991 Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic-ischemia. Dev Brain Res 64:115-120
34. 2+ is associated with irreversible tissue injury after brain trauma. J Biol Chem 263:757-761
35. Bareyre FM, Saatman KE, Helfaer MA, Sinson G, Weisser JD, Brown AL, McIntosh TK 1999 Alterations in ionized and total blood magnesium after experimental traumatic brain injury: relationship to neurobehavioral outcome and neuroprotective efficacy of magnesium chloride. J Neurochem 73:271-280
36. Regan RF, Jasper E, Guo Y, Panter SS 1998 The effect of magnesium on oxidative neuronal injury in vitro. J Neurochem 70:77-85
37. Blumberg RM, Cady BE, Wigglesworth JS, McKenzie JE, Edwards AD 1997 Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain. Exp Brain Res 113:130-137
38. McDonald JW, Silverstein FS, Johnston MV 1990 Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Neurosci Lett 109:234-238
39. Wolf G, Keilhoff G, Fischer S, Hass P 1990 Subcutaneously applied magnesium protects reliably against quinolinate-induced N-methyl-D-aspartate (NMDA)-mediated neurodegeneration and convulsions in rats: are there therapeutical implications? Neurosci Lett 117:207-211
40. McIntosh TK, Vink R, Yamakami I, Faden Al 1989 Magnesium protects against neurological deficit after brain injury. Brain Res 482:252-260
41. Izumi Y, Roussel S, Pinard E, Seylaz J 1991 Reduction of infarct volume by magnesium after middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 11:1025-1030
42. Thordstein M, Bågenholm R, Thiringer K, Kjellmer I 1993 Scavengers of free oxygen radicals in combination with magnesium ameliorate perinatal hypoxic-ischemic brain damage in the rat. Pediatr Res 34:23-26
43. 2+ administered up to twenty-four hours following reperfusion prevents ischemic damage of the CA1 neurons in the rat hippocampus. Neuroscience 44:335-341
44. Penrice J, Amess PN, Punwani S, Wylezinska M, Tyszczuk L, D'Souza P, Edwards AD, Cady EB, Wyatt JS, Reynolds EO 1997 Magnesium sulfate after transient hypoxia-ischemia fails to prevent delayed cerebral energy failure in the newborn piglet. Pediatr Res 41:443-447
45. de Haan HH, Gunn AJ, Williams CE, Heymann MA, Gluckman PD 1997 Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury. Am J Obstet Gynecol 176:18-27
46. Nelson KB, Grether JK 1995 Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants? Pediatrics 95:263-269
47. Schendel DE, Berg CJ, Yeargin-Allsop M, Boyle CA, Decoufle P 1996 Prenatal magnesium sulfate exposure and the risk for cerebral palsy or mental retardation among very low-birth-weight children aged 3 to 5 years. JAMA 276:1805-1810
48. Leviton A, Paneth N, Susser M, Reuss ML, Allred EN, Kuban K, Sanocka U, Hegyi T, Hiatt M, Shahrivar F, Van Marter LJ 1997 Maternal receipt of magnesium sulfate does not seem to reduce the risk of neonatal white matter damage. Pediatrics 99:E2