Maturational changes in cerebral lactate and acid clearance following ischemia measured in vivo using magnetic resonance spectroscopy and microdialysis

Developmental Brain Research

Volumn 113, Issue 1-2, 1999, Pages 37-46

  Corbett, Ron ^a   Laptook, Abbot ^a   Kim, Ben ^a   Tollefsbol, Greg ^a   Silmon, Sandra ^a   Garcia, Damian ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

31P MRS; Brain; Development; Ischemia; Lactic acidosis; Microdialysis

Indexed keywords

LACTIC ACID;

ANAEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN MATURATION; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; LACTIC ACIDOSIS; MICRODIALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OSMOLALITY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SWINE;

ACIDOSIS, LACTIC; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BRAIN ISCHEMIA; CEREBRAL CORTEX; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MICRODIALYSIS; PHOSPHORUS ISOTOPES; SWINE;

ANIMALIA; SUS SCROFA;

EID: 0033548414     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(98)00187-4     Document Type: Article

References (30)

1. Astrup J. Energy-requiring cell functions in the ischemic brain. J. Neurosurg. 56:1982;482-497.
2. Baethmann A., Kempski O. Biochemical factors and mechanisms of secondary brain damage in cerebral ischemia and trauma. Adv. Neurochem. 7:1992;295-320.
3. Cardell M., Koide T., Wieloch T. Pyruvate dehydrogenase activity in the rat cerebral cortex following cerebral ischemia. J. Cereb. Blood Flow Metab. 9:1989;350-357.
4. Chang L.-H., Shimizu H., Abiko H., Swanson R., Faden A., James T., Weinstein P. Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 12:1992;1030-1038.
5. Chopp M., Welch K.M.A., Tidwell C.D., Helpern J.A. Global cerebral ischemia and intracellular pH during hyperglycemia and hypoglycemia in cats. Stroke. 19:1988;1383-1387.
6. 31P NMR relaxation does not effect the quantitation of changes in phosphocreatine, inorganic phosphate and ATP measured in vivo during cerebral ischemia J. Neurochem. 61:1993;144-149.
7. 1H nuclear magnetic resonance spectroscopy J. Neurochem. 59:1992;216-226.
8. 31P NMR resonance peak of phosophoethanolamine Magn. Reson. Med. 6:1988;99-106.
9. Corbett R.J.T., Laptook A.R., Nunnally R.L. The use of the chemical shift of the phosphomonoester P-31 magnetic resonance peak for the determination of intracellular pH in the brains of neonates. Neurology. 37:1987;1771-1779.
10. Corbett R.J.T., Laptook A.R., Sterett R., Tollefsbol G., Garcia D. The effect of hypercarbia on age-related changes in cerebral glucose transport and glucose-modulated agonal glycolytic rates. Pediatr. Res. 34:1993;370-378.
11. Cunningham V.J., Sarna G.S. Estimation of the kinetic parameters of unidirectional transport across the blood-brain barrier. J. Neurochem. 33:1979;433-437.
12. Gjedde A. Modulation of substrate transport to the brain. Acta Neurol. Scand. 67:1983;3-25.
13. Harada M., Okuda C., Sawa T., Murakami T. Cerebral extracellular glucose and lactate concentrations during and after moderate hypoxia in glucose- and saline- infused rats. Anesthesiology. 77:1992;728-734.
14. Hochachka P.W. Defense strategies against hypoxia and hypothermia. Science. 231:1986;234-241.
15. Kuhr W., Korf J. Extracellular lactic acid as an indicator of brain metabolism: continuous on-line measurement in conscious, freely moving rats with intrastriatal dialysis. J. Cereb. Blood Flow Metab. 8:1988;130-137.
16. Laptook A., Corbett R., Arencibia-Mireles O., Ruley J. Glucose-associated alterations in ischemic brain metabolism of neonatal piglets. Stroke. 23:1992;1504-1511.
17. Laptook A., Corbett R., Ruley J., Olivares E. Blood flow and metabolism during and after repeated partial brain ischemia in neonatal piglets. Stroke. 23:1992;380-387.
18. O.H. Lowry, J.V. Passonneau, A flexible system of enzymatic analysis, Academic Press, New York, 1972.
19. Lundgren J., Cardell M., Wieloch T., Siesjo B. Preischemic hyperglycemia and post-ischemic alteration of rat brain pyruvate dehydrogenase activity. J. Cereb. Blood Flow Metab. 10:1990;536-541.
20. Medina J.M. The role of lactate as an energy substrate for the brain during the early neonatal period. Biol. Neonate. 48:1988;237-244.
21. Messeter K., Siesjo B.K. The intracellular pH in the brain in acute and sustained hypercapnia. Acta Physiol. Scand. 83:1971;210-219.
22. + exchange. TIBS. 11:1986;141-143.
23. Oldendorf W. Carrier-mediated blood-brain barrier mediated transport of short chain organic acids. Am. J. Physiol. 224:1973;1450-1453.
24. Paschen W., Djuricic B., Mies G., Schmidt-Kastner R., Linn F. Lactate and pH in the brain: association and dissociation in different pathophysiologic states. J. Neurochem. 48:1987;154-159.
25. 2. J. Cereb. Blood Flow Metab. 9:1989;65-70.
26. Rehncrona S. Brain acidosis. Ann. Emerg. Med. 14:1985;770-776.
27. Roos A., Boron W. Intracellular pH. Physiol. Rev. 61:1981;296-434.
28. Siesjo B., Katsura K., Mellergard P., Ekholm A., Lundgren J., Smith M.-L. Acidosis-related brain damage. Prog. Brain Res. 96:1993;23-48.
29. 1H -containing metabolites in rat brain after focal ischemia NMR Biomed. 8:1995;245-252.
30. Vannucci R.C., Mujsce D.J. Effect of glucose on perinatal hypoxic-ischemic brain damage. Biol. Neonate. 62:1992;215-224.