메뉴 건너뛰기




Volumn 17, Issue 10, 1999, Pages 1000-1005

Identification of a neuritogenic ligand of the neural cell adhesion molecule using a combinatorial library of synthetic peptides

Author keywords

Cell adhesion; Combinatorial chemistry; Drug discovery; Neural cell adhesion molecule; Neurite outgrowth; Nuclear magnetic resonance spectroscopy; Surface plasmon resonance; Synthetic peptide

Indexed keywords

LIGAND; NERVE CELL ADHESION MOLECULE; PEPTIDE; SYNTHETIC PEPTIDE;

EID: 0032826081     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/13697     Document Type: Article
Times cited : (124)

References (41)
  • 1
    • 0007589855 scopus 로고    scopus 로고
    • Cell recognition molecules of the immunoglobulin superfamily in the nervous system
    • Gegelashvili, G. & Bock, E. Cell recognition molecules of the immunoglobulin superfamily in the nervous system. Treatise Biomembranes 3, 33-75 (1996).
    • (1996) Treatise Biomembranes , vol.3 , pp. 33-75
    • Gegelashvili, G.1    Bock, E.2
  • 2
    • 0032434753 scopus 로고    scopus 로고
    • The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system
    • Rønn, L.C.B., Hartz, B.P. & Bock, E. The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system Exp.Gerontol. 33, 853-864 (1999).
    • (1999) Exp.Gerontol. , vol.33 , pp. 853-864
    • Rønn, L.C.B.1    Hartz, B.P.2    Bock, E.3
  • 3
    • 0030296833 scopus 로고    scopus 로고
    • Neural cell adhesion molecule in activity-dependent development and synaptic plasticity
    • Fields, R.D. & Itoh, K. Neural cell adhesion molecule in activity-dependent development and synaptic plasticity. Trends Neurosci. 19, 473-480 (1996).
    • (1996) Trends Neurosci. , vol.19 , pp. 473-480
    • Fields, R.D.1    Itoh, K.2
  • 4
    • 0027955570 scopus 로고
    • Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning
    • Cremer, H. et al. Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 367, 455-459 (1994).
    • (1994) Nature , vol.367 , pp. 455-459
    • Cremer, H.1
  • 5
    • 0027730439 scopus 로고
    • Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system
    • Tomasiewicz, H. et al. Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system. Neuron 11, 1163-1174 (1993).
    • (1993) Neuron , vol.11 , pp. 1163-1174
    • Tomasiewicz, H.1
  • 6
    • 0345095249 scopus 로고
    • Neural cell adhesion molecule (N-CAM) accumulates in denervated and paralyzed skeletal muscles
    • Covault, J. & Sanes, J.R. Neural cell adhesion molecule (N-CAM) accumulates in denervated and paralyzed skeletal muscles. Proc. Natl. Acad. Sci. USA 82, 4544-4548 (1985).
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 4544-4548
    • Covault, J.1    Sanes, J.R.2
  • 7
    • 0028946921 scopus 로고
    • The ability to re-express polysialylated NCAM in soleus muscle after denervation is reduced in aged rats compared to young adult rats
    • Olsen, M., Zuber, C., Roth, J., Linnemann, D. & Bock, E. The ability to re-express polysialylated NCAM in soleus muscle after denervation is reduced in aged rats compared to young adult rats. Int. J. Dev. Neurosci. 13, 97-104 (1995).
    • (1995) Int. J. Dev. Neurosci. , vol.13 , pp. 97-104
    • Olsen, M.1    Zuber, C.2    Roth, J.3    Linnemann, D.4    Bock, E.5
  • 8
    • 0026693379 scopus 로고
    • Hippocampal NCAM180 transiently increases sialylation during the acquisition and consolidation of a passive avoidance response in the adult rat
    • Doyle, E., Nolan, P.M., Bell, R. & Regan, C.M. Hippocampal NCAM180 transiently increases sialylation during the acquisition and consolidation of a passive avoidance response in the adult rat. J. Neurosci. Res. 31, 513-523 (1992).
    • (1992) J. Neurosci. Res. , vol.31 , pp. 513-523
    • Doyle, E.1    Nolan, P.M.2    Bell, R.3    Regan, C.M.4
  • 9
    • 0028670787 scopus 로고
    • Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM
    • Lüthi, A., Laurent, J.P., Figurov, A., Muller, D. & Schachner, M. Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. Nature 372, 777-779 (1994).
    • (1994) Nature , vol.372 , pp. 777-779
    • Lüthi, A.1    Laurent, J.P.2    Figurov, A.3    Muller, D.4    Schachner, M.5
  • 10
    • 0028963861 scopus 로고
    • NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1
    • Rønn, L.C.B., Bock, E., Linnemann, D. & Jahnsen, H. NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1. Brain Res. 677, 145-151 (1995).
    • (1995) Brain Res. , vol.677 , pp. 145-151
    • Rønn, L.C.B.1    Bock, E.2    Linnemann, D.3    Jahnsen, H.4
  • 11
    • 0027261388 scopus 로고
    • A role for the neural cell adhesion molecule (NCAM) in a late, consolidating phase of glycoprotein synthesis 6 hours following passive avoidance training of the young chick
    • Scholey, A.B., Rose, S.P.R., Zamani, M.R., Bock, E. & Schachner, M. A role for the neural cell adhesion molecule (NCAM) in a late, consolidating phase of glycoprotein synthesis 6 hours following passive avoidance training of the young chick. Neuroscience 55, 499-509 (1993).
    • (1993) Neuroscience , vol.55 , pp. 499-509
    • Scholey, A.B.1    Rose, S.P.R.2    Zamani, M.R.3    Bock, E.4    Schachner, M.5
  • 12
    • 0017660974 scopus 로고
    • Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina
    • Thiery, J.P., Brackenbury, R., Rutishauser, U. & Edelman, G.M. Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina. J. Biol. Chem. 252, 6841-6845 (1977).
    • (1977) J. Biol. Chem. , vol.252 , pp. 6841-6845
    • Thiery, J.P.1    Brackenbury, R.2    Rutishauser, U.3    Edelman, G.M.4
  • 13
    • 0024236038 scopus 로고
    • Characterization of the kinetics of neural cell adhesion molecule homophilic binding
    • Moran, N. & Bock, E. Characterization of the kinetics of neural cell adhesion molecule homophilic binding. FEBS Lett. 242, 121-124 (1988).
    • (1988) FEBS Lett. , vol.242 , pp. 121-124
    • Moran, N.1    Bock, E.2
  • 14
    • 0024425966 scopus 로고
    • Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix
    • Probstmeier, R., Kuhn, K. & Schachner, M. Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix. J. Neurochem. 53, 1794-1801 (1989).
    • (1989) J. Neurochem. , vol.53 , pp. 1794-1801
    • Probstmeier, R.1    Kuhn, K.2    Schachner, M.3
  • 15
    • 0025173903 scopus 로고
    • The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions
    • Kadmon, G., Kowitz, A., Altevogt, P. & Schachner, M. The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions. J. Cell Biol. 110, 193-208 (1990).
    • (1990) J. Cell Biol. , vol.110 , pp. 193-208
    • Kadmon, G.1    Kowitz, A.2    Altevogt, P.3    Schachner, M.4
  • 16
    • 0030221511 scopus 로고    scopus 로고
    • CAM-FGF receptor interactions: A model for axonal growth
    • Doherty, P. & Walsh, F.S. CAM-FGF receptor interactions: a model for axonal growth. Mol. Cell. Neurosci. 8, 99-111 (1996).
    • (1996) Mol. Cell. Neurosci. , vol.8 , pp. 99-111
    • Doherty, P.1    Walsh, F.S.2
  • 17
    • 0024693393 scopus 로고
    • Neural cell adhesion molecules influence second messenger systems
    • Schuch, U., Lohse, M.J. & Schachner, M. Neural cell adhesion molecules influence second messenger systems. Neuron 3, 13-20 (1989).
    • (1989) Neuron , vol.3 , pp. 13-20
    • Schuch, U.1    Lohse, M.J.2    Schachner, M.3
  • 18
    • 0025949919 scopus 로고
    • Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal calcium-channels
    • Doherty, P., Ashton, S.V., Moore, S.E. & Walsh, F.S. Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal calcium-channels. Cell 67, 21-33 (1991).
    • (1991) Cell , vol.67 , pp. 21-33
    • Doherty, P.1    Ashton, S.V.2    Moore, S.E.3    Walsh, F.S.4
  • 19
    • 0030887348 scopus 로고    scopus 로고
    • NCAM140 interacts with the focal adhesion kinase p125fak and the SRC-related tyrosine kinase p59fyn
    • Beggs, H.E., Baragona, S.C., Hemperly, J.J. & Maness, P.F. NCAM140 interacts with the focal adhesion kinase p125fak and the SRC-related tyrosine kinase p59fyn. J. Biol. Chem. 272, 8310-8319 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 8310-8319
    • Beggs, H.E.1    Baragona, S.C.2    Hemperly, J.J.3    Maness, P.F.4
  • 20
    • 0028836221 scopus 로고
    • The neural cell adhesion molecule (N-CAM) inhibits proliferation in primary cultures of rat astrocytes
    • Sporns, O., Edelman, G.M. & Crossin, K.L. The neural cell adhesion molecule (N-CAM) inhibits proliferation in primary cultures of rat astrocytes. Proc. Natl. Acad. Sci. USA 92, 542-546 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 542-546
    • Sporns, O.1    Edelman, G.M.2    Crossin, K.L.3
  • 21
    • 0028360081 scopus 로고
    • Transfection of glioma cells with the neural-cell adhesion molecule NCAM: Effect on glioma-cell invasion and growth in vivo
    • Edvardsen, K. et al. Transfection of glioma cells with the neural-cell adhesion molecule NCAM: effect on glioma-cell invasion and growth in vivo. Int. J. Cancer 58, 116-122 (1994).
    • (1994) Int. J. Cancer , vol.58 , pp. 116-122
    • Edvardsen, K.1
  • 22
    • 0032478335 scopus 로고    scopus 로고
    • Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation
    • Krushel, L.A., Tai, M.H., Cunningham, B.A., Edelman, G.M. & Crossin, K.L. Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation. Proc. Natl. Acad. Sci. USA 95, 2592-2596 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2592-2596
    • Krushel, L.A.1    Tai, M.H.2    Cunningham, B.A.3    Edelman, G.M.4    Crossin, K.L.5
  • 23
    • 0028036803 scopus 로고
    • Mechanism of homophilic binding mediated by the neural cell adhesion molecule NCAM. Evidence for isologous interaction
    • Rao, Y., Zhao, X. & Siu, C.H. Mechanism of homophilic binding mediated by the neural cell adhesion molecule NCAM. Evidence for isologous interaction. J. Biol. Chem. 269, 27540-27548 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 27540-27548
    • Rao, Y.1    Zhao, X.2    Siu, C.H.3
  • 24
    • 0029867737 scopus 로고    scopus 로고
    • Homophilic adhesion mediated by the neural cell adhesion molecule involves multiple immunoglobulin domains
    • Ranheim, T.S., Edelman, G.M. & Cunningham, B.A. Homophilic adhesion mediated by the neural cell adhesion molecule involves multiple immunoglobulin domains. Proc. Natl. Acad. Sci. USA 93, 4071-4075 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4071-4075
    • Ranheim, T.S.1    Edelman, G.M.2    Cunningham, B.A.3
  • 25
    • 0029980152 scopus 로고    scopus 로고
    • The three-dimensional structure of the first domain of neural cell adhesion molecule
    • Thomsen, N.K. et al. The three-dimensional structure of the first domain of neural cell adhesion molecule. Nat. Struct. Biol. 3, 581-585. (1996).
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 581-585
    • Thomsen, N.K.1
  • 26
    • 0030899695 scopus 로고    scopus 로고
    • The first immunoglobulin-like neural cell adhesion molecule (NCAM) domain is involved in double-reciprocal interaction with the second immunoglobulin-like NCAM domain and in heparin binding
    • Kiselyov, V.V. et al. The first immunoglobulin-like neural cell adhesion molecule (NCAM) domain is involved in double-reciprocal interaction with the second immunoglobulin-like NCAM domain and in heparin binding. J. Biol. Chem. 272, 10125-10134 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 10125-10134
    • Kiselyov, V.V.1
  • 27
    • 0032933306 scopus 로고    scopus 로고
    • Structure and interactions of NCAM modules 1 and 2 - Basic elements in neural cell adhesion
    • Jensen, P.M. et al. Structure and interactions of NCAM modules 1 and 2 - basic elements in neural cell adhesion. Nat. Struct. Biol. 6, 486-493 (1999).
    • (1999) Nat. Struct. Biol. , vol.6 , pp. 486-493
    • Jensen, P.M.1
  • 28
    • 0030773876 scopus 로고    scopus 로고
    • Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
    • Cwirla, S.E. et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 276, 1696-1699 (1997).
    • (1997) Science , vol.276 , pp. 1696-1699
    • Cwirla, S.E.1
  • 29
    • 9444236174 scopus 로고    scopus 로고
    • Small peptides as potent mimetics of the protein hormone erythropoietin
    • Wrighton, N.C. et al. Small peptides as potent mimetics of the protein hormone erythropoietin. Science 273, 458-464 (1996).
    • (1996) Science , vol.273 , pp. 458-464
    • Wrighton, N.C.1
  • 30
    • 0031034591 scopus 로고    scopus 로고
    • Characterization of microwell cultures of dissociated brain tissue for studies of cell-cell interactions
    • Maar, T.E. et al. Characterization of microwell cultures of dissociated brain tissue for studies of cell-cell interactions. J. Neurosci. Res. 47, 163-172 (1997).
    • (1997) J. Neurosci. Res. , vol.47 , pp. 163-172
    • Maar, T.E.1
  • 31
    • 0028029162 scopus 로고
    • Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, NCAM, and N-cadherin
    • Williams, E.J., Furness, J., Walsh, F.S. & Doherty, P. Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, NCAM, and N-cadherin. Neuron 13, 583-594 (1994).
    • (1994) Neuron , vol.13 , pp. 583-594
    • Williams, E.J.1    Furness, J.2    Walsh, F.S.3    Doherty, P.4
  • 32
    • 0028290261 scopus 로고
    • Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF
    • Williams, E.J., Furness, J., Walsh, F.S. & Doherty, P. Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF. Development 120, 1685-1693 (1994).
    • (1994) Development , vol.120 , pp. 1685-1693
    • Williams, E.J.1    Furness, J.2    Walsh, F.S.3    Doherty, P.4
  • 33
    • 0028851543 scopus 로고
    • FGF inhibits neurite outgrowth over monolayers of astrocytes and fibroblasts expressing transfected cell adhesion molecules
    • Williams, E.J., Mittal, B., Walsh, F.S. & Doherty, P. FGF inhibits neurite outgrowth over monolayers of astrocytes and fibroblasts expressing transfected cell adhesion molecules. J. Cell Sci. 108, 3523-3530 (1995).
    • (1995) J. Cell Sci. , vol.108 , pp. 3523-3530
    • Williams, E.J.1    Mittal, B.2    Walsh, F.S.3    Doherty, P.4
  • 34
    • 0028213852 scopus 로고
    • Tyrosine kinase inhibitors can differentially inhibit integrin-dependent and CAM-stimulated neurite outgrowth
    • Williams, E.J., Walsh, F.S. & Doherty, P. Tyrosine kinase inhibitors can differentially inhibit integrin-dependent and CAM-stimulated neurite outgrowth. J. Cell Biol. 124, 1029-1037 (1994).
    • (1994) J. Cell Biol. , vol.124 , pp. 1029-1037
    • Williams, E.J.1    Walsh, F.S.2    Doherty, P.3
  • 35
    • 0025893762 scopus 로고
    • General method for rapid synthesis of multicomponent peptide mixtures
    • Furka, A., Sebestyen, F., Asgedom, M. & Dibo, G. General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Pept. Prot. Res. 37, 487-493 (1991).
    • (1991) Int. J. Pept. Prot. Res. , vol.37 , pp. 487-493
    • Furka, A.1    Sebestyen, F.2    Asgedom, M.3    Dibo, G.4
  • 36
    • 0028921285 scopus 로고
    • Novel avidin and streptavidin binding sequences found in synthetic peptide libraries
    • Østergaard, S., Hansen, P.H., Olsen, M. & Holm, A. Novel avidin and streptavidin binding sequences found in synthetic peptide libraries. FEBS Lett. 362, 306-308 (1995).
    • (1995) FEBS Lett. , vol.362 , pp. 306-308
    • Østergaard, S.1    Hansen, P.H.2    Olsen, M.3    Holm, A.4
  • 37
    • 0344448273 scopus 로고
    • Coherence transfer by isotropic mixing: Application to proton correlation spectroscopy
    • Braunsweiler, L. & Ernst, R.R. Coherence transfer by isotropic mixing: Application to proton correlation spectroscopy. J. Magn. Reson. 53, 521-528 (1983).
    • (1983) J. Magn. Reson. , vol.53 , pp. 521-528
    • Braunsweiler, L.1    Ernst, R.R.2
  • 38
    • 0005963761 scopus 로고
    • Multiple quantum filters for elucidating NMR coupling networks
    • Piantini, U., Sørensen, O.W. & Ernst, R.R. Multiple quantum filters for elucidating NMR coupling networks. J. Am. Chem. Soc. 104, 6800-6801 (1982).
    • (1982) J. Am. Chem. Soc. , vol.104 , pp. 6800-6801
    • Piantini, U.1    Sørensen, O.W.2    Ernst, R.R.3
  • 39
    • 12644267957 scopus 로고
    • Buildup rates of the nuclear Overhauser effect measured by two-dimensional proton magnetic resonance spectroscopy: Implications for studies of protein conformation
    • Kumar, A., Wagner, G., Ernst, R.R. & Wüthrich, K. Buildup rates of the nuclear Overhauser effect measured by two-dimensional proton magnetic resonance spectroscopy: implications for studies of protein conformation. J. Am. Chem. Soc. 103, 3654-3658 (1981).
    • (1981) J. Am. Chem. Soc. , vol.103 , pp. 3654-3658
    • Kumar, A.1    Wagner, G.2    Ernst, R.R.3    Wüthrich, K.4
  • 40
    • 0011491177 scopus 로고
    • Structure determination of a tetrasaccharide: Transient nuclear Overhauser effects in the rotating frame
    • Bothner-By, A.A., Stephens, R.L., Lee, J., Warren, C.D. & Jeanloz, R.W. Structure determination of a tetrasaccharide: transient nuclear Overhauser effects in the rotating frame. J. Am. Chem. Soc. 106, 811-813 (1984).
    • (1984) J. Am. Chem. Soc. , vol.106 , pp. 811-813
    • Bothner-By, A.A.1    Stephens, R.L.2    Lee, J.3    Warren, C.D.4    Jeanloz, R.W.5
  • 41
    • 0028673711 scopus 로고
    • Automated and semiautomated analysis of homo- and heteronuclear multidimensional nuclear magnetic resonance spectra of proteins: The program Pronto
    • Kjær, M., Andersen, M.K. & Poulsen, F.M. Automated and semiautomated analysis of homo- and heteronuclear multidimensional nuclear magnetic resonance spectra of proteins: the program Pronto. Methods Enzymol. 239, 288-307 (1994).
    • (1994) Methods Enzymol. , vol.239 , pp. 288-307
    • Kjær, M.1    Andersen, M.K.2    Poulsen, F.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.