Infrequent alteration in the p53R2 gene in human transitional cell carcinoma of the urinary tract

Pathobiology

Volumn 71, Issue 2, 2004, Pages 103-106

  Hayashi, Hideki ^a   Furihata, Mutsuo ^b   Kuwahara, Morimasa ^a   Kagawa, Susumu ^c   Shuin, Taro ^b   Ohtsuki, Yuji ^b  

^a Fujisaki Hospital   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Bladder cancer; Genetic analysis; p53R2; Renal pelvic cancer; Transitional cell carcinoma; Ureter cancer

Indexed keywords

GENOMIC DNA; PROTEIN P53; PROTEIN SUBUNIT;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; BLADDER CARCINOGENESIS; BLADDER CARCINOMA; CANCER GENETICS; CARCINOGENESIS; CODON; CONTROLLED STUDY; EXON; FEMALE; FUNGAL GENE; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; HUMAN; HUMAN TISSUE; INTRON; KIDNEY PELVIS CARCINOMA; MALE; NUCLEAR LOCALIZATION SIGNAL; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TRANSITIONAL CELL CARCINOMA; URETER CARCINOMA; URINARY TRACT CARCINOMA; YEAST;

AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; BASE SEQUENCE; CARCINOMA, TRANSITIONAL CELL; CELL CYCLE PROTEINS; DNA, NEOPLASM; FEMALE; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; RIBONUCLEOTIDE REDUCTASES; UROLOGIC NEOPLASMS;

EID: 0347594246     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074424     Document Type: Article

References (14)

1. Modrich P, Lahue R: Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu Rev Biochem 1996;65:101-133.
2. Ford JM, Hanawalt PC: Li-Fraumeni syndrome fibroblast homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proc Natl Acad Sci USA 1995;92:8876-8880.
3. Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 2000;404:42-49.
4. Nakano K, Balint E, Ashcroft M, Vousden KH: A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene 2000; 19:4283-4289.
5. Reichard P: From RNA to DNA, why so many ribonucleotide reductases? Science 1993;260: 1773-1777.
6. Byun DS, Chae KS, Ryu BK, Lee MG, Chi SG: Expression and mutation analyses of p53R2, a newly identified p53 target for DNA repair in human gastric carcinoma. Int J Cancer 2002; 98:718-723.
7. Smeds J, Kumar R, Hemminki K: Polymorphic insertion of additional repeat within an area of direct 8 bp tandem repeats in the 5′-untranslated region of the p53R2 gene and cancer risk. Mutagenesis 2001;16:547-550.
8. Ye Z, Parry JM: The discovery and confirmation of single nucleotide polymorphisms in the human p53R2 gene by EST database analysis. Mutagenesis 2002;17:361-364.
9. Engstrom Y, Rozell B: Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase. EMBO J 1988;7:1615-1620.
10. Furihata M, Takeuchi T, Matsumoto M, Kurabayashi A, Ohtsuki Y, Terao N, Kuwahara M, Shuin T: p53 mutation arising in Arg72 allele in the tumorigenesis and development of carcinoma of the urinary tract. Clin Cancer Res 2002;8:1192-1195.
11. Furihata M, Kurabayashi A, Matsumoto M, Sonobe H, Ohtsuki Y, Terao N, Kuwahara M, Shuin T: Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract. J Pathol 2002;197:82-88.
12. Elledge SJ, Davis RW: Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: A DNA damage-inducible gene required for mitotic viability. Mol Cell Biol 1987; 7:2783-2793.
13. Yamaguchi T, Matsuda K, Sagiya Y, Iwadate M, Fujino MA, Nakamura Y, Arakawa H: p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint. Cancer Res 2001;61:8256-8262.
14. Shiohara M, El-Deiry WS, Wada M, Nakamaki T, Takeuchi S, Yang R, Chen DL, Vogelstein B, Koeffler HP: Absence of WAF1 mutations in a variety of human malignancies. Blood 1994;84: 3781-3784.