-
1
-
-
0345794238
-
-
(Takeda Chemical Industries, Ltd.). Tricyclic cpds., their production and use. EP 0885210, JP 1998287665, JP 1999152281, WO 9732871
-
Miyamoto, M., Ohkawa, S., Uchikawa, O., Fukatsu, K. (Takeda Chemical Industries, Ltd.). Tricyclic cpds., their production and use. EP 0885210, JP 1998287665, JP 1999152281, WO 9732871.
-
-
-
Miyamoto, M.1
Ohkawa, S.2
Uchikawa, O.3
Fukatsu, K.4
-
2
-
-
0347686104
-
Discovery of the novel melatonin agonist TAK-375
-
(Nov 27-29, Shizuoka), Abst IL 11
-
Ohkawa, S. Discovery of the novel melatonin agonist TAK-375. 22nd Symp Med Chem (Nov 27-29, Shizuoka) 2002, Abst IL 11.
-
(2002)
22nd Symp Med Chem
-
-
Ohkawa, S.1
-
3
-
-
0037068471
-
Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists
-
Uchikawa, O., Fukatsu, K., Tokunoh, R. et al. Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists. J Med Chem 2002, 45: 4222-39.
-
(2002)
J Med Chem
, vol.45
, pp. 4222-4239
-
-
Uchikawa, O.1
Fukatsu, K.2
Tokunoh, R.3
-
4
-
-
0037270505
-
Suprachiasmatic control of melatonin synthesis in rats: Inhibitory and stimulatory mechanisms
-
Perreau-Lenz, S., Kalsbeek, A., Garidou, M.L., Wortel, J., van der Vliet, J., van Heijningen, C., Simonneaux, V., Pevet, P., Buijs, R.M. Suprachiasmatic control of melatonin synthesis in rats: Inhibitory and stimulatory mechanisms. Eur J Neurosci 2003, 17: 221-8.
-
(2003)
Eur J Neurosci
, vol.17
, pp. 221-228
-
-
Perreau-Lenz, S.1
Kalsbeek, A.2
Garidou, M.L.3
Wortel, J.4
Van Der Vliet, J.5
Van Heijningen, C.6
Simonneaux, V.7
Pevet, P.8
Buijs, R.M.9
-
5
-
-
0035057808
-
Circadian rhythm sleep disorders: Pathophysiology and potential approaches to management
-
Zisapel, N. Circadian rhythm sleep disorders: Pathophysiology and potential approaches to management. CNS Drugs 2001, 15: 311-28.
-
(2001)
CNS Drugs
, vol.15
, pp. 311-328
-
-
Zisapel, N.1
-
6
-
-
0033755796
-
A critical assesment of the melatonin effect on sleep in humans
-
Monti, J.M., Cardinali, D.P. A critical assesment of the melatonin effect on sleep in humans. Biol Signals Recept 2000, 9: 328-39.
-
(2000)
Biol Signals Recept
, vol.9
, pp. 328-339
-
-
Monti, J.M.1
Cardinali, D.P.2
-
7
-
-
0036257955
-
Future of melatonin as a therapeutic agent
-
Karasek, M., Reiter, R.J., Cardinali, D.P., Pawlikowski, M. Future of melatonin as a therapeutic agent. Neuroendocrinol Lett 2002, 23(Suppl. 1): 118-21.
-
(2002)
Neuroendocrinol Lett
, vol.23
, Issue.SUPPL. 1
, pp. 118-121
-
-
Karasek, M.1
Reiter, R.J.2
Cardinali, D.P.3
Pawlikowski, M.4
-
8
-
-
5644288880
-
TAK-375 and its metabolites are selective agonists at MLs1s receptors
-
Abst 0193.C
-
Hirai, K., Kato, K., Nishiyama, H., Hinuma, S., Uchikawa, O., Ohkawa, S., Miyamoto, M. TAK-375 and its metabolites are selective agonists at MLs1s receptors. Sleep 2003, 26(Suppl.): Abst 0193.C.
-
(2003)
Sleep
, vol.26
, Issue.SUPPL.
-
-
Hirai, K.1
Kato, K.2
Nishiyama, H.3
Hinuma, S.4
Uchikawa, O.5
Ohkawa, S.6
Miyamoto, M.7
-
10
-
-
0030761518
-
Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock
-
Liu, C., Weaver, D., Jin, X., Shearman, L., Pieschl, R., Gribkoff, V., Reppert, S.M. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 1997, 19: 91-102.
-
(1997)
Neuron
, vol.19
, pp. 91-102
-
-
Liu, C.1
Weaver, D.2
Jin, X.3
Shearman, L.4
Pieschl, R.5
Gribkoff, V.6
Reppert, S.M.7
-
11
-
-
0031821519
-
Cellular mechanisms of melatonin action
-
Vanecek, J. Cellular mechanisms of melatonin action. Physiol Rev 1998, 78: 687-721.
-
(1998)
Physiol Rev
, vol.78
, pp. 687-721
-
-
Vanecek, J.1
-
12
-
-
0345794231
-
TAK-375 and its active metabolite: Lack of binding to non-ML receptor binding sites
-
Abst 0194.C
-
Miyamoto, M., Kato, K., Hirai, K., Uchikawa, O., Ohkawa, S. TAK-375 and its active metabolite: Lack of binding to non-ML receptor binding sites. Sleep 2003, 26(Suppl.): Abst 0194.C.
-
(2003)
Sleep
, vol.26
, Issue.SUPPL.
-
-
Miyamoto, M.1
Kato, K.2
Hirai, K.3
Uchikawa, O.4
Ohkawa, S.5
-
13
-
-
60349126957
-
1-selective melatonin receptor agonist, on entrainment function in circadian rhythm
-
(March 24-26, Fukuoka), Abst 3D0854
-
1-selective melatonin receptor agonist, on entrainment function in circadian rhythm. 76th Annu Meet Jpn Pharmacol Soc(March 24-26, Fukuoka) 2003, Abst 3D0854.
-
(2003)
76th Annu Meet Jpn Pharmacol Soc
-
-
Inoue, S.1
Shimazoe, T.2
Moriya, T.3
Shinohara, K.4
Miyamoto, M.5
Watanabe, S.6
-
14
-
-
0347055530
-
1-selective melatonin receptor agonist, in experimental animals
-
Abst P.03.125
-
1-selective melatonin receptor agonist, in experimental animals. Int J Neuropsychopharmacol 2000, 3(Suppl. 1): Abst P.03.125.
-
(2000)
Int J Neuropsychopharmacol
, vol.3
, Issue.SUPPL. 1
-
-
Miyamoto, M.1
Nishikawa, H.2
Ohta, H.3
Hirai, K.4
Uchikawa, O.5
Fukatsu, K.6
Ohkawa, S.7
-
15
-
-
0347686101
-
Synthesis and sleep promoting action of TAK-375, a novel melatonin agonist
-
(Dec 6-8, Tokyo), Abst 1 P-28
-
Fukatsu, K., Uchikawa, O., Kato, K., Nishikawa, H., Hinuma, S., Miyamoto, M., Ohkawa, S. Synthesis and sleep promoting action of TAK-375, a novel melatonin agonist. 20th Symp Med Chem (Dec 6-8, Tokyo) 2000, Abst 1 P-28.
-
(2000)
20th Symp Med Chem
-
-
Fukatsu, K.1
Uchikawa, O.2
Kato, K.3
Nishikawa, H.4
Hinuma, S.5
Miyamoto, M.6
Ohkawa, S.7
-
16
-
-
0347686097
-
Effects of TAK-375, a novel melatonin receptor agonist, on sleep in freely moving monkeys
-
Abst P.03.127
-
Yukuhiro, N., Kimura, H., Nishikawa, H., Ohkawa, S., Miyamoto, M. Effects of TAK-375, a novel melatonin receptor agonist, on sleep in freely moving monkeys. Int J Neuropsychopharmacol 2000, 3(Suppl. 1): Abst P.03.127.
-
(2000)
Int J Neuropsychopharmacol
, vol.3
, Issue.SUPPL. 1
-
-
Yukuhiro, N.1
Kimura, H.2
Nishikawa, H.3
Ohkawa, S.4
Miyamoto, M.5
-
17
-
-
0347055536
-
Sleep in freely moving monkeys: Comparison of TAK-375, melatonin, and zolpidem
-
Abstract 0195.C
-
Yukuhiro, N., Nishikawa, H., Kimura, H., Ohkawa, S., Miyamoto, M. Sleep in freely moving monkeys: Comparison of TAK-375, melatonin, and zolpidem. Sleep 2003, 26(Suppl.): Abstract 0195.C.
-
(2003)
Sleep
, vol.26
, Issue.SUPPL.
-
-
Yukuhiro, N.1
Nishikawa, H.2
Kimura, H.3
Ohkawa, S.4
Miyamoto, M.5
-
18
-
-
0345794229
-
Effects of TAK-375, a novel melatonin receptor agonist, on sleep in freely moving monkeys at nighttime
-
Abst P-791
-
Yukuhiro, N., Nishikawa, H., Kimura, H., Ohkawa, S., Miyamoto, M. Effects of TAK-375, a novel melatonin receptor agonist, on sleep in freely moving monkeys at nighttime. Jpn J Pharmacol 2001, 85(Suppl. 1): Abst P-791.
-
(2001)
Jpn J Pharmacol
, vol.85
, Issue.SUPPL. 1
-
-
Yukuhiro, N.1
Nishikawa, H.2
Kimura, H.3
Ohkawa, S.4
Miyamoto, M.5
-
19
-
-
0347712871
-
Effect of age and gender on the pharmacodynamics of TAK-375: Tests of sedation, psychomotor function, and memory
-
Abst 0197.C.
-
Greenblatt, D.J., Harmatz, J.S. Effect of age and gender on the pharmacodynamics of TAK-375: Tests of sedation, psychomotor function, and memory. Sleep 2003, 26(Suppl.): Abst 0197.C.
-
(2003)
Sleep
, vol.26
, Issue.SUPPL.
-
-
Greenblatt, D.J.1
Harmatz, J.S.2
-
20
-
-
0346425198
-
Effect of age on the pharmacokinetics and pharmacodynamics of TAK-375: A novel selective ML-1 receptor agonist under investigation for the treatment of insomnia
-
(Aug 17-22, Chicago), Abst PA-015
-
Greenblatt, D.J., Harmatz, J.S., Stubbs, C. Effect of age on the pharmacokinetics and pharmacodynamics of TAK-375: A novel selective ML-1 receptor agonist under investigation for the treatment of insomnia. 11th Int Congr Int Psychogeriatr Assoc (Aug 17-22, Chicago) 2003, Abst PA-015.
-
(2003)
11th Int Congr Int Psychogeriatr Assoc
-
-
Greenblatt, D.J.1
Harmatz, J.S.2
Stubbs, C.3
-
21
-
-
0345794226
-
Age and gender effects on the pharmacokinetics of TAK-375
-
Abst 0198.C.
-
Greenblatt, D.J. Harmatz, J.S. Age and gender effects on the pharmacokinetics of TAK-375. Sleep 2003, 26(Suppl.): Abst 0198.C.
-
(2003)
Sleep
, vol.26
, Issue.SUPPL.
-
-
Greenblatt, D.J.1
Harmatz, J.S.2
-
22
-
-
0346452179
-
A safety, tolerance, and pharmacokinetic study of five single doses of TAK-375 in healthy adults
-
Abst 0187.C.
-
Stubbs, C., Karim, A. A safety, tolerance, and pharmacokinetic study of five single doses of TAK-375 in healthy adults. Sleep 2003, 26(Suppl.): Abst 0187.C.
-
(2003)
Sleep
, vol.26
, Issue.SUPPL.
-
-
Stubbs, C.1
Karim, A.2
-
23
-
-
0347082504
-
Phase II study of the selective ML-1 receptor agonist TAK-375 in a first night effect model of transient insomnia
-
Abst 0739.L.
-
Roth, T., Walsh, J. Phase II study of the selective ML-1 receptor agonist TAK-375 in a first night effect model of transient insomnia. Sleep 2003, 26(Suppl.): Abst 0739.L.
-
(2003)
Sleep
, vol.26
, Issue.SUPPL.
-
-
Roth, T.1
Walsh, J.2
-
24
-
-
0347082506
-
Phase II study of the selective ML-1 receptor agonist TAK-375 in subjects with primary chronic insomnia
-
Abst 0748.L.
-
Erman, M., Seiden, D., Zammit, G. Phase II study of the selective ML-1 receptor agonist TAK-375 in subjects with primary chronic insomnia. Sleep 2003, 26(Suppl.): Abst 0748.L.
-
(2003)
Sleep
, vol.26
, Issue.SUPPL.
-
-
Erman, M.1
Seiden, D.2
Zammit, G.3
-
25
-
-
0346425194
-
Synthesis of a novel series of tricyclic indan derivatives as melatonin agonists
-
(Sept 18-22, Bologna), Abst PB-108
-
Ohkawa, S., Uchikawa, O., Fukatsu, K., Tokunoh, R., Kawada, M., Matsumoto, K., Imai, Y., Kato, K., Nishikawa, H., Miyamoto, M. Synthesis of a novel series of tricyclic indan derivatives as melatonin agonists. 16th Int Symp Med Chem (Sept 18-22, Bologna) 2000, Abst PB-108.
-
(2000)
16th Int Symp Med Chem
-
-
Ohkawa, S.1
Uchikawa, O.2
Fukatsu, K.3
Tokunoh, R.4
Kawada, M.5
Matsumoto, K.6
Imai, Y.7
Kato, K.8
Nishikawa, H.9
Miyamoto, M.10
|