Recurrence of Acute Myelogenous Leukemia with the Same AML1/ETO Breakpoint as at Diagnosis after Complete Remission Lasting 15 Years: Analysis of Stored Bone Marrow Smears

International Journal of Hematology

Volumn 78, Issue 4, 2003, Pages 362-369

  Tsukamoto, Norifumi ^a   Karasawa, Masamitsu ^b   Tanaka, Yoko ^a   Yokohama, Akihiko ^a   Uchiumi, Hideki ^a   Matsushima, Takafumi ^a   Murakami, Hirokazu ^b   Nojima, Yoshihisa ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Acute leukemia; AML1 ETO gene; Bone marrow slides; Long term remission

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AML1 ETO GENE; ARTICLE; BLAST CELL; BONE MARROW BIOPSY; CANCER RECURRENCE; CANCER REGRESSION; CASE REPORT; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION; CLONE; EXCISION REPAIR; FEMALE; FUSION GENE; GENE EXPRESSION; GENE LOCATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; INTRON; INVERSE POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SOUTHERN BLOTTING;

EID: 0347480534     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02983563     Document Type: Article

References (37)

1. Swirsky DM, Li YS, Matthews JG, Flemans RL, Rees JKH, Hayhoe FGJ. 8;21 translocation in acute granulocytic leukemia: cytological, cytochemical and clinical features. Br J Haematol. 1984;56:199-213.
2. Berger R, Flandrin G, Bernheim A, et al. Cytogenetic studies on 519 consecutive de novo acute nonlymphocytic leukemias. Cancer Genet Cytogenet. 1987;29:9-21.
3. Nicifora G, Larson RA, Rowley JD. Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission. Blood. 1993;82:712-715.
4. Downing JR, Head JR, Curcio-Brint AM. et al. An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation. Blood. 1993;81:2860-2865.
5. Miyoshi H, Kozu T, Shimizu K, et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 1993;7:2715-2721.
6. Frank R, Zhang J, Uchida H, Meyers S, Hiebert SW, Nimer SD. The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene. 1995;11:2667-2674.
7. Meyers S, Lenny N, Hiebert SW. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol. 1995;15:1974-1982.
8. Burel SA, Harakawa N, Zhou L, Pabst T, Tenen DG, Zhang D-E. Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation. Mol Cell Biol. 2001;16:5577-5590.
9. Appelbaum FR, Kopecky KJ. Long-term survival after chemotherapy for acute myeloid leukemia: the experience of the Southwest Oncology Group. Cancer. 1997;80(suppl):2199-2204.
10. Miyamoto T, Nakafuji K, Akashi K, et al. Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia. Blood. 1996;87:4789-4796.
11. Jurlander J, Caligiuri MA, Ruutu T, et al. Persistence of the AML1/ ETO fusion transcript in patients treated with bone marrow transplantation for t(8;21) leukemia. Blood. 1996;88:2183-2191.
12. Tobel K, Newton J, Macheta M, et al. Molecular quantification of minimal residual disease in acute myeloid leukemia with t(8;21) can identify patients in durable remission and predict clinical relapse. Blood. 2000;95:815-819.
13. Satake N, Maseki N, Kozu T, et al. Disappearance of AML1-MTG8 (ETO) fusion transcript in acute myeloid leukaemia patients with t(8;21) in long-term remission. Br J Haematol 1995;91:892-898
14. Muto A, Mori S, Matsushita H, et al. Serial quantification of minimal residual disease of t(8;21) acute myelogenous leukemia with RT-competitive PCR assay. Br J Haematol. 1996;95:85-94.
15. Willis TG, Jadayel DM, Coignet LJA, et al. Rapid molecular cloning of rearrangements of the IGHJ locus using long-distance inverse polymerase chain reaction. Blood. 1997;90:2456-2464.
16. Akasaka H, Akasaka T, Kurata M, et al. Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays. Cancer Res. 2000;60:2335-2341.
17. Peterson BA, Bloomfield CD. Prolonged maintained remissions of adult acute non-lymphocytic leukemia. Lancet. 1977;2:158-160.
18. Sauter C, Fehr J, Frick P, Gmuer J, Honegger H, Martz G. Acute myelogenous leukemia: successful treatment of relapse with cytosine arabinoside, VP 16-213, vincristine and vinblastine (A-triple V). Eur J Cancer Clin Oncol. 1982;18:733-737.
19. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning:A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2001.
20. Fey MF, Pilkington SP, Summers C, Wainscoat JS. Molecular diagnosis of haematological disorders using DNA from stored bone marrow slides. Br J Haematol. 1987;67:489-492.
21. Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA. 1991;88:10431-10434.
22. Shimizu K, Miyoshi H, Kozu T, et al. Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation. Cancer Res. 1992;52:6945-6948.
23. Erickson O, Gao J, Chang KS, et al. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood. 1992;80:1825-1831.
24. Kozu T, Miyoshi H, Shimizu K, et al. Junctions of the AML1/MTG8 (ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood. 1993;82:1270-1276.
25. Tighe JE, Daga T, Calabi F. Translocation breakpoints are clustered on both chromosome 8 and chromosome 21 in the t(8;21) of acute myeloid leukemia. Blood. 1993;81:592-596.
26. Jowitt SN, Yin JA, Saunders MJ. Relapse myelodysplastic clone differs from acute onset clone as shown by X-linked DNA polymorphism patterns in a patient with acute myeloid leukemia. Blood. 1993;82:613-618.
27. Hayashi Y, Raimondi SC, Behm FG, et al. Two karyotypically independent leukemic clones with the t(8;21) and 11q23 translocation in acute myeloblastic leukemia at relapse. Blood. 1989;73:1650-1655.
28. Bernstein ML, Esseltine DW, Emond J, Vekemans M. Acute lymphoblastic leukemia at relapse in a child with acute myeloblastic leukemia. Am J Pediatr Hematol Oncol. 1986;8:153-157.
29. Rhoades KL, Hetherington CJ, Harakawa N, et al. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood. 2000;96:2108-2115.
30. Lorsbach RB, Downing JR. The role of the AML1 transcription factor in leukemogenesis. Int J Hematol. 2001;74:258-265.
31. Marcucci G, Livak KI, Bi W, Strout MO, Bloomfield CD, Caligiuri MA. Detection of minimal residual disease in patients with AML1/ ETO-associated acute myeloid leukemia using a novel quantitative reverse transcription polymerase chain reaction assay. Leukemia. 1998;12:1482-1489.
32. Krauter J, Wattjes MP, Nagel S, et al. Real-time RT-PCR for the detection and quantification of AML1/MTG8 fusion transcripts in t(8;21) -positive AML patients. Br J Haematol. 1999;107:80-85.
33. Morschhauser F, Cayuela JM, Martini S, et al. Evaluation of minimal residual disease using reverse-transcription polymerase chain reaction in t(8;21) acute myeloid leukemia: a multicenter study of 51 patients. J Clin Oncol. 2000;18:788-794.
34. Sugimoto T, Das H, Imoto S, et al. Quantification of minimal residual disease in t(8;21)-positive acute myelogenous leukemia patients using real-time quantitative RT-PCR. Am J Hematol. 2000;64:101-106.
35. Grünewald K, Lyons J, Hansen-Hagge TE, Janssen JWG, Feichtinger H, Bartram CR. Molecular genetic analysis of DNA obtained from fixed, air dried or paraffin embedded sources. Ann Hematol. 1991;62:108-114.
36. Shibata D, Martin WJ, Arnheim N. Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology. Cancer Res. 1988;48:4564-4566.
37. Merkelbach S, Gehlen J, Handt S, Füzesi L. Novel enzyme immunoassay and optimized DNA extraction for the detection of polymerase-chain-reaction-amplified viral DNA from paraffin-embedded tissue. Am J Pathol. 1997;150:1537-1546.