Trypanosome apoptotic factor mediates apoptosis in human brain vascular endothelial cells

Molecular and Biochemical Parasitology

Volumn 133, Issue 2, 2004, Pages 229-240

  Stiles, Jonathan K ^a   Whittaker, Joseph ^a   Sarfo, Bismark Y ^a   Thompson, Winston E ^a   Powell, Michael D ^a   Bond, Vincent C ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

African trypanosomiasis; Apoptosis; Brain; Procyclin; SELDI; Trypanosoma

Indexed keywords

APOPTOSIS INDUCING FACTOR; PROTEIN DERIVATIVE; PROTOZOAL PROTEIN; SYNTHETIC PEPTIDE; TRYPANOSOME APOPTOTIC FACTOR; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOASSAY; BRAIN BLOOD VESSEL; BRAIN CELL; BRAIN TISSUE; CELL ASSAY; CELL LYSATE; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DESORPTION; DNA DETERMINATION; HUMAN; HUMAN CELL; IONIZATION; LASER; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE CULTIVATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DATABASE; PROTEIN EXPRESSION; PROTEIN MICROARRAY; SOLUBILITY; SUPERNATANT; TRYPANOSOMA BRUCEI; WESTERN BLOTTING;

EPICOCCUM; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0347418185     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2003.10.011     Document Type: Article

References (45)

1. Reincke M., Arlt W., Heppner C., Petzke F., Chrousos G.P., Allolio B. Neuroendocrine dysfunction in African trypanosomiasis. The role of cytokines. Ann. N Y Acad. Sci. 840:1998;809-821.
2. Haller L., Adams H., Merouze F., Dago A. Clinical and pathological aspects of human African trypanosomiasis (T. b.gambiense) with particular reference to reactive arsenical encephalopathy. Am. J. Trop. Med. Hyg. 35:1986;94-99.
3. Greenwood B.M., Whittle H.C. The pathogenesis of sleeping sickness. Trans. R Soc. Trop. Med. Hyg. 74:1980;716-725.
4. Schmidt H. The pathogenesis of trypanosomiasis of the CNS. Studies on parasitological and neurohistological findings in Trypanosoma rhodesiense infected vervet monkeys. Virchows Arch A Pathol. Anat. Histopathol. 399:1983;333-343.
5. Adams J.H., Haller L., Boa F.Y., Doua F., Dago A., Konian K. Human African trypanosomiasis (Tb. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. Neuropathol. Appl. Neurobiol. 12:1986;81-94.
6. Blum J., Nkunku S., Burri C. Clinical description of encephalopathic syndromes and risk factors for their occurrence and outcome during melarsoprol treatment of human African trypanosomiasis. Trop. Med. Int. Health. 6:2001;390-400.
7. Dumas M., Bouteille B. Human African trypanosomiasis. C R Seances Soc. Biol. Fil. 190:1996;395-408.
8. Gear J.H., Miller G.B. The clinical manifestations of Rhodesian trypanosomiasis: an account of cases contracted in the Okavango swamps of Botswana. Am. J. Trop. Med. Hyg. 35:1986;1146-1152.
9. Mabbott N.A., Sutherland I.A., Sternberg J.M. Suppressor macrophages in Trypanosoma brucei infection: nitric oxide is related to both suppressive activity and lifespan in vivo. Parasite Immunol. 17:1995;143-150.
10. Manuelidis E.E., Robertson D.H., Amberson J.M., Polak M., Haymaker W. Trypanosoma rhodesiense encephalitis. Clinicopathological study of five cases of encephalitis and one of mel B hemorrhagic encephalopathy. Acta Neuropathol. (Berl). 5:1965;176-204.
11. Stiles J.K., Meade J.C., Kucerova Z.et al. Trypanosoma brucei infection induces apoptosis and up-regulates neuroleukin expression in the cerebellum. Ann. Trop. Med. Parasitol. 95:2001;797-810.
12. Quan N., Mhlanga J.D., Whiteside M.B.et al. Chronic overexpression of proinflammatory cytokines and histopathology in the brains of rats infected with Trypanosoma brucei. J. Comp. Neurol. 414:1999;114-130.
13. van Deursen F.J., Shahi S.K., Turner M.R.et al. Characterization of the growth and differentiation in vivo and in vitro of bloodstream-form Trypanosoma brucei strain TREU 927. Mol. Biochem. Parasitol. 112:2001;163-171.
14. Lanham, Godfrey. Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose. Exp Parasitol 1970;28:521-34.
15. Cunningham I., Honigberg B.M. Infectivity reacquisition by Trypanosoma brucei brucei cultivated with tsetse salivary glands. Science. 197:1977;1279-1282.
16. Acosta-Serrano A., Cole R.N., Mehlert A., Lee M.G., Ferguson M.A., Englund P.T. The procyclin repertoire of Trypanosoma brucei. Identification and structural characterization of the Glu-Pro-rich polypeptides. J. Biol. Chem. 274:1999;29763-29771.
17. Acosta-Serrano A., Vassella E., Liniger M.et al. The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly. Proc. Natl. Acad. Sci. USA. 98:2001;1513-1518.
18. Magez S., Radwanska M., Beschin A., Sekikawa K., De Baetselier P. Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections. Infect. Immun. 67:1999;3128-3132.
19. Stennicke H.R., Salvesen G.S. Caspase assays. Methods Enzymol. 322:2000;91-100.
20. Namura S., Zhu J., Fink K.et al. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 18:1998;3659-3668.
21. Hartmann A., Hunot S., Michel P.P.et al. Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc. Natl. Acad. Sci. USA. 97:2000;2875-2880.
22. Zheng J., Thylin M.R., Ghorpade A.et al. Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1 associated dementia. J. Neuroimmunol. 98:1999;185-200.
23. Thompson W.E., Powell J.M., Whittaker J.A., Sridaran R., Thomas K.H. Immunolocalization and expression of prohibitin, a mitochondrial-associated protein within the rat ovaries. Anatomical. Record. 256:1999;40-48.
24. Vassella E., Acosta-Serrano A., Studer E., Lee S.H., Englund P.T., Roditi I. Multiple procyclin isoforms are expressed differentially during the development of insect forms of Trypanosoma brucei. J. Mol. Biol. 312:2001;597-607.
25. Pino P., Vouldoukis I., Kolb J.P.et al. Plasmodium falciparum - infected erythrocyte adhesion induces caspase activation and apoptosis in human endothelial cells. J. Infect. Dis. 187:2003;1283-1290.
26. Gavrilescu L.C., Denkers E.Y. IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection. J. Immunol. 167:2001;902-909.
27. el-Kowrany S.I., Sallam F.A., Nassar S.O., Ismail H.I., Eissa M.M. The role of Fas system [as-FasL]as an inducer of apoptosis in cutaneous leishmaniasis: a combined human and experimental study. J. Egypt Soc. Parasitol. 31:2001;245-256.
28. Acosta Rodriguez E.V., Zuniga E., Montes C.L., Gruppi A. Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation. J. Leukoc. Biol. 73:2003;127-136.
29. Zuniga E., Motran C., Montes C.L., Diaz F.L., Bocco J.L., Gruppi A. Trypanosoma cruzi-induced immunosuppression: B cells undergo spontaneous apoptosis and lipopolysaccharide (LPS) arrests their proliferation during acute infection. Clin. Exp. Immunol. 119:2000;507-515.
30. Adamo S.A. Modulating the modulators: parasites, neuromodulators and host behavioral change. Brain Behav. Evol. 60:2002;370-377.
31. Kristensson K., Mhlanga J.D., Bentivoglio M. Parasites and the brain: neuroinvasion, immunopathogenesis and neuronal dysfunctions. Curr. Top. Microbiol. Immunol. 265:2002;227-257.
32. Antunes A.C., Cecchini F.M., Bolli F.B.et al. Cerebral trypanosomiasis and AIDS. Arq. Neuropsiquiatr. 60:2002;730-733.
33. Enanga B., Burchmore R.J., Stewart M.L., Barrett M.P. Sleeping sickness and the brain. Cell Mol. Life Sci. 59:2002;845-858.
34. Schmahmann J.D., Sherman J.C. Cerebellar cognitive affective syndrome. Int. Rev. Neurobiol. 41:1997;433-440.
35. Burri C, Brun R. Human African trypanosomiasis. In: Cook GC, Zumla A, editors. Mansons tropical diseases. Elsevier, 2003;73:1303-1323.
36. Pays E., Coquelet H., Tebabi P.et al. Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters. EMBO J. 9:1990;3145-3151.
37. Roditi I., Furger A., Ruepp S., Schurch N., Butikofer P. Unravelling the procyclin coat of Trypanosoma brucei. Mol. Biochem. Parasitol. 91:1998;117-130.
38. Hotz H.R., Biebinger S., Flaspohler J., Clayton C. PARP gene expression: control at many levels. Mol. Biochem. Parasitol. 91:1998;131-143.
39. Furger A., Schurch N., Kurath U., Roditi I. Elements in the 3′ untranslated region of procyclin mRNA regulate expression in insect forms of Trypanosoma brucei by modulating RNA stability and translation. Mol. Cell Biol. 17:1997;4372-4380.
40. Schurch N., Furger A., Kurath U., Roditi I. Contributions of the procyclin 3′ untranslated region and coding region to the regulation of expression in bloodstream forms of Trypanosoma brucei. Mol. Biochem. Parasitol. 89:1997;109-121.
41. Girard M., Bisser S., Courtioux B.et al. In vitro induction of microglial and endothelial cell apoptosis by cerebrospinal fluids from patients with human African trypanosomiasis. Int. J. Parasitol. 33:2003;713-720.
42. Barcinski M.A., DosReis G.A. Apoptosis in parasites and parasite-induced apoptosis in the host immune system: a new approach to parasitic diseases. Braz. J. Med. Biol. Res. 32(4):1999;395-401.
43. Toure-Balde A., Sarthou J.L., Aribot G.et al. Plasmodium falciparum induces apoptosis in human mononuclear cells. Infect. Immun. 64:1996;744-750.
44. Nyakundi J.N., Crawley B., Pentreath V.W. The relationships between endotoxins, nitric oxide and inflammatory cytokines in blood and intestinal tissues in experimental Trypanosoma brucei brucei infections. Parasitology. 124:2002;597-604.
45. Carneiro-Santos P., Martins-Filho O., Alves-Oliveira L.F.et al. Apoptosis: a mechanism of immunoregulation during human Schistosomiasis mansoni. Parasite Immunol. 22:2000;267-277.