The Chemical Development of LB71350

Organic Process Research and Development

Volumn 7, Issue 6, 2003, Pages 839-845

  Lee, Kyu Woong ^a   So, Byungran ^a   Cho, Sung Wook ^a   Shin, Hyunik ^a   Hwang, Sang Yeul ^a   Kim, Chung Ryeol ^a   Nam, Do Hyun ^a   Chang, Jay Hyok ^a   Choi, Sang Chul ^a   Choi, Bo Seung ^a   Choi, Hyeong Wook ^a   Lee, Ki Kon ^a  

^a LG Chemical Ltd   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBAMIC ACID; CARBONYL DERIVATIVE; LB 71350; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VALINE;

ARTICLE; DRUG SELECTIVITY; DRUG SYNTHESIS; EPOXIDATION; HUMAN IMMUNODEFICIENCY VIRUS 1; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0347365758     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op034062w     Document Type: Article

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17. 3) δ 8.39 (d, 1H, J = 4.1 Hz) 7.95 (d, 2H, J = 7.4 Hz), 7.85-7.65 (m, 15H), 7.55-7.42 (m, 2H), 5.08 (dd, 1H, J = 6.9, 5.5 Hz), 3.84-3.74 (m, 2H), 3.14-3.11 (m, 2H), 2.30 (m, 1H), 0.98 (d, 6H, J = 6.0 Hz). (Equation presented)
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36. 3, respectively.
37. 4 in methanol. Cbz-L-phenylalaninol and Cbz-D-phenylalaninol showed retention time 11.5 and 13.7 min, respectively, under the analysis conditions: Chiralpack (4.5 mm i.d. x 250 mm, Daicel, Japan), 210 nm, 1.0 mL/min, hexane/2-propanol = 90/10.
38. In-process analysis showed that the reaction was completed in 6 h.
39. Carbon tetrachloride is harmful to liver, kidney, and central nervous system. Exposure to 1000-2000 ppm for 30-60 min can be fatal to humans.