Initiation of Gonadotropin-Releasing Hormone Antagonist on Day 1 as Compared to Day 6 of Stimulation: Effect on Hormonal Levels and Follicular Development in in Vitro Fertilization Cycles

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 12, 2003, Pages 5632-5637

  Kolibianakis, Efstratios M ^a   Albano, Carola ^a   Camus, Michel ^a   Tournaye, Herman ^a   Van Steirteghem, Andre C ^a   Devroey, Paul ^a  

^a CENTRE FOR REPRODUCTIVE MEDICINE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; ESTRADIOL; ESTROGEN RECEPTOR; ESTRONE; GONADORELIN ANTAGONIST;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HORMONAL REGULATION; HORMONE DETERMINATION; HUMAN; LUTEINIZING HORMONE RELEASE; MAJOR CLINICAL STUDY; OOCYTE MATURATION; OVARY CYCLE; OVARY FOLLICLE DEVELOPMENT; OVULATION INDUCTION; PREGNANCY RATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; STEROIDOGENESIS; THECA CELL;

ADULT; CHORIONIC GONADOTROPIN; DRUG ADMINISTRATION SCHEDULE; EMBRYO IMPLANTATION; ESTRADIOL; FEMALE; FERTILIZATION; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HUMANS; INFERTILITY, FEMALE; LUTEINIZING HORMONE; OVARIAN FOLLICLE; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; RECOMBINANT PROTEINS;

EID: 0347362891     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030805     Document Type: Article

References (26)

1. Albano C, Smitz J, Camus M, Riethmuller-Winzen H, Siebert-Weigel M, Diedrich K, Van Steirteghem AC, Devroey P 1996 Hormonal profile during the follicular phase in cycles stimulated with a combination of human menopausal gonadotrophin and gonadotrophin-releasing hormone antagonist (Cetrorelix) Hum Reprod 11:2114-2118
2. Olivennes F, Alvarez S, Bouchard P, Fanchin R, Salat-Baroux J, Frydman R 1998 The use of a GnRH antagonist (Cetrorelix) in a single dose protocol in IVF-embryo transfer: a dose finding study of 3 versus 2 mg. Hum Reprod 13:2411-2414
3. Borm G, Mannaerts B 2000 Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle-stimulating hormone is effective, safe and convenient: results of a controlled, randomized, multicentre trial. The European Orgalutran Study Group. Hum Reprod 15:1490-1498
4. Fluker M, Grifo J, Leader A, Levy M, Meldrum D, Muasher SJ, Rinehart J, Rosenwaks Z, Scott Jr RT, Schoolcraft W, Shapiro DB 2001 Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. Fertil Steril 75:38-45
5. Albano C, Felberbaum RE, Smitz J, Riethmuller-Winzen H, Engel J, Diedrich K, Devroey P 2000 Ovarian stimulation with HMG: results of a prospective randomized phase III European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist Cetrorelix and the LHRH-agonist buserelin. European Cetrorelix Study Group. Hum Reprod 15:526-531
6. 2001 European and Middle East Orgalutran Study Group Comparable clinical outcome using the GnRH antagonist ganirelix or a long protocol of the GnRH agonist triptorelin for the prevention of premature LH surges in women undergoing ovarian stimulation. Hum Reprod 16:644-651
7. Olivennes F, Belaisch-Allart J, Emperaire JC, Dechaud H, Alvarez S, Moreau L, Nicollet B, Zorn JR, Bouchard P, Frydman R 2000 Prospective, randomized, controlled study of in vitro fertilization - embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (Cetrorelix) or a depot formula of an LH-RH agonist (triptorelin). Fertil Steril 73:314-320
8. Ludwig M, Katalinic A, Banz C, Schroder AK, Loning M, Weiss JM, Diedrich K 2002 Tailoring the GnRH antagonist Cetrorelix acetate to individual patients' needs in ovarian stimulation for IVF: results of a prospective, randomized study. Hum Reprod 17:2842-2845
9. Diedrich K, Diedrich C, Santos E, Zoll C, al-Hasani S, Reissmann T, Krebs D, Klingmuller D 1994 Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod 9:788-791
10. Al-Inany H, Aboulghar M 2001 Gonadotrophin-releasing hormone antagonists for assisted conception. Cochrane Database Syst Rev:CD001750
11. Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P 2002 Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin-releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril 78:1025-1029
12. Kolibianakis EM, Albano C, Kahn J, Camus M, Tournaye H, Van Steirteghem AC, Devroey P 2003 High exposure to LH and E2 in the early follicular phase of GnRH antagonist cycles is associated with a reduced chance of pregnancy. Fertil Steril 79:873-880
13. Elkind-Hirsch KE, Webster BW, Brown CP, Vernon MW 2003 Concurrent ganirelix and follitropin β-therapy is an effective and safe regimen for ovulation induction in women with polycystic ovary syndrome. Fertil Steril 79: 603-607
14. Falck S 1959 Site of the production of estrogen in rat ovary as studies in micro-transplants, PhD thesis, University of Lund, Sweden
15. Zeleznik AJ, Midgley Jr AR, Reichert Jr LE 1974 Granulosa cell maturation in the rat: increased binding of human chorionic gonadotropin following treatment with follicle-stimulating hormone in vivo. Endocrinology 95:818-825
16. Kessel B, Liu YX, Jia XC, Hsueh AJ 1985 Autocrine role of estrogens in the augmentation of luteinizing hormone receptor formation in cultured rat granulosa cells. Biol Reprod 32:1038-1050
17. Erickson GF, Wang C, Hsueh AJ 1979 FSH induction of functional LH receptors in granulosa cells cultured in a chemically defined medium. Nature 279:336-338
18. Zeleznik AJ, Hillier SG 1984 The role of gonadotropins in the selection of the preovulatory follicle. Clin Obstet Gynecol 27:927-940
19. Wang C, Hsueh AJ, Erickson GF 1981 LH stimulation of estrogen secretion by cultured rat granulosa cells. Mol Cell Endocrinol 24:17-28
20. Ben-Chetrit A, Gotlieb L, Wong PY, Casper RF 1996 Ovarian response to recombinant human follicle-stimulating hormone in luteinizing hormone-depleted women: examination of the two cell, two gonadotropin theory. Fertil Steril 65:711-717
21. Shoham Z, Mannaerts B, Insler V, Coelingh-Bennink H 1993 Induction of follicular growth using recombinant human follicle-stimulating hormone in two volunteer women with hypogonadotropic hypogonadism. Fertil Steril 59:738-742
22. School DC, Harlin J, Shoham Z, Mannaerts BM, Lahlou N, Bouchard P, Bennink HJ, Fauser BC 1994 Recombinant human follicle-stimulating hormone and ovarian response in gonadotrophin-deficient women. Hum Reprod 9:1237-42
23. The European Recombinant Human LH Study Group 1998 Recombinant human luteinizing hormone (LH) to support recombinant human follicle-stimulating hormone (FSH)-induced follicular development in LH-and FSH-deficient anovulatory women: a dose-finding study. J Clin Endocrinol Metab 83:1507-1514
24. Findlay JK, Britt K, Kerr JB, O'Donnell L, Jones ME, Drummond AE, Simpson ER 2001 The road to ovulation: the role of oestrogens. Reprod Fertil Dev 13:543-547
25. Drummond AE, Findlay JK 1999 The role of estrogen in folliculogenesis. Mol Cell Endocrinol 151:57-64
26. Marchini M, Fedele L, Bianchi S, Losa GA, Ghisletta M, Candiani GB 1991 Secretory changes in preovulatory endometrium during controlled ovarian hyperstimulation with buserelin acetate and human gonadotropins. Fertil Steril 55:717-721