Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 368, Issue 6, 2003, Pages 487-495

  Chang, Ling Ling ^a   Wun, Wan Song Alfred ^b   Ho, L Low Tone ^c,d   Wang, Paulus S ^c,d  

^a CHINESE CULTURE UNIVERSITY   (Taiwan)

^b Obstetrical and Gynecological Associates   (United States)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

cAMP; DHEA; P450scc; StAR; Zona fasciculata reticularis cells

Indexed keywords

25 HYDROXYCHOLESTEROL; 8 BROMO CYCLIC AMP; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORTICOSTERONE; CORTICOTROPIN; CYCLIC AMP; DEOXYCORTICOSTERONE; FORSKOLIN; PRASTERONE; PREGNENOLONE; PROGESTERONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ADRENAL CORTEX; ANIMAL CELL; ARTICLE; BODY FAT; CANCER; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; DRUG MECHANISM; ENZYME INHIBITION; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLIPIDEMIA; NONHUMAN; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZONA FASCICULATA;

1-METHYL-3-ISOBUTYLXANTHINE; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELLS, CULTURED; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CORTICOSTERONE; CYCLIC AMP; DEHYDROEPIANDROSTERONE; DESOXYCORTICOSTERONE; DIHYDROTESTOSTERONE; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION; HYDROXYCHOLESTEROLS; PHOSPHOPROTEINS; PREGNENOLONE; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STEROID 11-BETA-HYDROXYLASE; ZONA FASCICULATA; ZONA RETICULARIS;

EID: 0347361474     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0846-9     Document Type: Article

References (35)

1. Aragno M, Tamagno E, Boccuzzi G, Brignardello E, Chiarpotto E, Pizzini A, Danni O (1993) Dehydroepiandrosterone pretreatment protects rats against the pro-oxidant and necrogenic effects of carbon tetrachloride. Biochem Pharmacol 46:1689-1694
2. Aragno M, Brignardello E, Tamagno E, Gatto V, Danni O, Boccuzzi G (1997) Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats. J Endocrinol 155:233-240
3. Aragno M, Tamagno E, Gatto V, Brignardello E, Parola S, Danni O, Boccuzzi G (1999) Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress. Free Radic Biol Med 26:1467-1474
4. Bastianetto S, Ramassamy C, Poirier J, Quiron R (1999) Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Brain Res Mol Brain Res 66:35-41
5. Berdanier C, Parente J, McIntosh M (1993) Is DHEA an antiobesity agent? FASEB J 7:414-419
6. Boccuzzi G, Aragno M, Seccia M, Brignardello E, Tamagno E, Albano E, Danni O, Bellomo G (1997) Protective effect of dehydroepiandrosterone against copper-induced lipid peroxidation in the rat. Free Radic Biol Med 22:1289-1294
7. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
8. Brignardello E, Beltramo E, Molinatti PA, Aragno M, Gatto V, Tamagno E, Danni O, Porta M, Boccuzzi G (1998) Dehydroepiandrosterone protects bovine retinal capillary pericytes against glucose toxicity. J Endocrinol 158:21-26
9. Chang LL, Tseng YC, Lin YL, Wun WSA, Wang PS (2002) Effects of S-petasin on corticosterone release in rats. Chin J Physiol 45:137-142
10. Chen YH, Lo MJ, Kau MM, Tsai SC, Chiao YC, Chen JJ, Liaw C, Lu CC, Lee BP, Chen SC, Fang VS, Ho LT, Wang PS (1997) Inhibition of corticosterone secretion by thyroxine in male rats. Chin J Physiol 40:25-30
11. Clark BJ, Wells J, King SR, Stocco DM (1994) The purification, cloning and expression of a novel LH-induced mitochondrial protein in MA-10 mouse Leydig tumor cells: characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem 269:28314-28322
12. Cleary M (1990) Role of DHEA in obesity. In: Kalimi M, Regelson W (eds) The biological role of dehydroepiandrosterone. de Gruyter, Berlin, pp 356-361
13. Clegg CH, Abrahamsen MS, Degen JL, Morris DR, Mcknight GS (1992) Cyclic AMP-dependent protein kinase controls base gene activity and steroidogenesis in Y1 adrenal tumor cells. Biochemistry 31:3720-3726
14. Coleman DL (1989) Therapeutic effects of DHEA and its metabolites in diabetes-obesity mutants. In: Lardy H, Stratman F (eds) Hormones, thermogenesis, and obesity. Elsevier, New York, pp 377-384
15. Gordon G, Helzlouer K, Comstock G (1991) Serum levels of DHEA and its sulfate and the risk of developing bladder cancer. Cancer Res 51:1366-1369
16. Hu MC, Guo IC, Lin JH, Chung BC (1991) Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein. Biochem J 274:813-817
17. Kau MM, Chen JJ, Wang SW, Cho WL, Wang PS (1999a) Age-related impairment of aldosterone secretion in zona glomerulosa cells of ovariectomized rats. J Invest Med 47:425-432
18. Kau MM, Lo MJ, Wang SW, Tsai SC, Chen JJ, Chiao YC, Yeh JY, Lin H, Shum AY C, Fang VS, Ho LT, Wang PS (1999b) Inhibition of aldosterone production by testosterone in male rats. Metabolism 49:1108-1114
19. Lo MJ, Kau MM, Chen YH, Tsai SC, Chiao YC, Chen JJ, Liaw C, Lu CC, Lee BP, Chen SC, Fang VS, Ho LT, Wang PS (1998) Acute effects of thyroid hormones on the production of adrenal cAMP and corticosterone in male rats. Am J Physiol 274: E238-E245
20. Lo MJ, Kau MM, Cho WL, Wang PS (2000) Aging effects on the secretion of corticosterone in male rats. J Invest Med 48: 335-342
21. Lu SS, Lau CP, Tung YF, Huang SW, Chen YH, Shih HC, Tasi SC, Lu CC, Wang SW, Chen JJ, Chien EJ, Chien CH, Wang PS (1996) Lactate stimulates progesterone secretion via an increase in cAMP production in exercised female rats. Am J Physiol 271:E910-915
22. Orly J, Rei Z, Greenberg N, Richards JS (1994) Tyrosine kinase inhibitor AG18 arrests FSH-induced granulosa cell differentiation: use of semi-quantitative RT-PCR assay for multiple mRNA. Endocrinology 134:2336-2346
23. Penhoat A, Jaillard C, Saez JM (1994) Regulation of bovine adrenal cell corticotropin receptor mRNA levels by corticotropin (ACTH) and angiotensin-II (A-II). Mol Cell Endocrinol 103: R7-R10
24. Purdy SJ, Whitehouse BJ, Abayasekara DRE (1991) Stimulation of steroidogenesis by forskolin in rat adrenal zona glomerulosa preparations. J Endocrinol 129:391-397
25. Ronen-Fuhrmann T, Timberg R, King SR, Hales KH, Hales DB, Stocco DM, Orly J (1998) Spatio-temporal expression patterns of steroidogenic acute regulatory protein (StAR) during follicular development in the rat ovary. Endocrinology 139:303-315
26. Scheterson LC, McKnight GS (1991) Role of cyclic adenosine 3′,5′-monophosphate-dependent protein kinase in hormone-stimulated beta-endorphin secretion in AtT20 cells. Mol Endocrinol 5:170-178
27. Schimmer BP (1980) Cyclic nucleotides in hormonal regulation of adrenocortical function. Adv Cyclic Nucleotide Res 13:181-214
28. Schwartz A, Whitcomb J, Fairman D, Hastings L, Lewbart M (1989) Inhibition of tumorigenesis by DHEA and structural analogues. In: Lardy H, Stratman F (eds) Hormones, thermogenesis, and obesity. Elsevier, New York, pp 441-452
29. Simpson ER, Waterman MR (1988) Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. Annu Rev Physiol 50:427-440
30. Simpson ER, McCarthy JL, Peterson JA (1979) Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450. J Biol Chem 253:3135-3139
31. Steel ROD, Torrie JH (1960) Principles and procedures of statistics. McGraw Hill, New York
32. Stocco DM, Clark BJ (1996) Role of the steroidogenic acute regulatory protein (StAR) in steroidogenesis. Biochem Pharmacol 51:197-205
33. Svee F, Porter J (1998) The actions of exogenous dehydroepiandrosterone in experimental animals and humans. Proc Soc Exp Biol Med 218:174-191
34. Wellman M, McWhorter SL, Orlando PL, Jennings JP (1999) The role of dehydroepiandrosterone in diabetes mellitus. Pharmacotherapy 19:582-591
35. Wong M, Krolczyk AJ, Schimmer BP (1992) The causal relationship between mutations in cAMP-dependent protein kinase and the loss of adrenocorticotropin- regulated adrenocortical functions. Mol Endocrinol 6:1614-1624