Rational design of powder formulations for tamp filling processes

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 12, 2003, Pages 1593-1599

  Hardy, Ian J ^a   Fitzpatrick, Shaun ^a   Booth, Steven W ^a  

^a Merck Sharp & Dohme Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CALCIUM PHOSPHATE; CALCIUM PHOSPHATE DIBASIC; CROSCARMELLOSE SODIUM; ELCEMA; GELATIN; LACTOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; SILICON DIOXIDE; STARCH; STARCH GLYCOLATE SODIUM; TALC;

BULK DENSITY; CAPSULE FILLING; DRUG CAPSULE; DRUG DESIGN; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG INDUSTRY; DRUG PELLET; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; EXPERIMENTATION; KINETICS; MEDICAL LITERATURE; PHARMACEUTICAL CARE; PHARMACOLOGICAL PARAMETERS; POWDER; PREDICTION; PUBLISHING; QUALITATIVE ANALYSIS; REVIEW; TABLET COMPRESSION; TABLET MACHINE;

CAPSULES; CHEMISTRY, PHARMACEUTICAL; POWDERS;

EID: 0347359073     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357022610     Document Type: Review

References (28)

1. Adams, M. J., McKeown, R. (1996) Micromechanical analyses of the pressure-volume relationships for powders under confined uniaxial compression. Powder Technol. 88: 155-163
2. Chopra, R., Podczeck, F., Newton, J. M., Alderborn, G. (2000) The influence of pellet shape and film coating on the filling of pellets into hard shell capsules. Eur. J. Pharm. Biopharm. 53: 327-333
3. Cropp, J. W., Augsburger, L. L., Marshall, K. (1991) Simultaneous monitoring of tamping force and pin displacement (F-D) on an Hofliger Karg capsule filling machine. Int. J. Pharm. 71: 127-136
4. Davar, N., Shah, R., Pope, D. G., Augsburger, L. L. (1997) The selection of a dosing disk on a Hofilger-Karg capsule-filling machine. Pharm. Technol. 21: 32-48
5. Hauer, B., Remmele, T., Zuge, O., Sucker, H. (1993) Gezieltes Endtwikeln und Optimieren von Kapsulformulierungen mit einer instrumentierten Dosierröhrchen-Kapselabfüllmaschine. 1. Mitt: Instrumentierung und Einfluβ der Füllgut und Maschinenparameter. Pharm. Ind. 55: 509-515
6. Hardy, I. J., Cook, W. G. (2003) Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms. J. Pharm. Pharmacol. 55: 3-18
7. Heda, P. K., Muteba, K., Augsburger, L. L. (2002) Comparison of the formulation requirements of dosator and dosing disk automatic capsule filling machines. AAPS Pharm. Sci. 4: article 17
8. Hogan, J., Shue, P. I., Podczeck, F., Newton, J. M. (1996) Investigations into the relationship between drug properties, filling, and the release of drugs from hard gelatin capsules using multivariate statistical analysis. Pharm. Res. 13: 944-949
9. Jones, B. E. (1988) Powder formulations for capsule filling. Manuf. Chem. 2: 28-33
10. Jones, B. E. (2001) The filling of powders into two-piece hard capsules. Int. J. Pharm. 227: 5-26
11. Mehta, A. M., Augsburger, L. L. (1981) A preliminary study of the effect of slug hardness on drug dissolution from hard gelatin capsules filled on an automatic capsule-filling machine. Int. J. Pharm. 7: 327-334
12. Mohammadi, M. S., Harnby, N. (1997) Bulk density modelling as a means of typifying the microstructure and flow characteristics of cohesive powders. Powder Technol. 92: 1-8
13. Mok, W. (2000) Effect of Process Parameters on Capsule Plug Formation Using Instrumented Encapsulator Tamping Blocks. Internal memorandum, Merck Research Laboratories, December 12th 2000
14. Newton, J. M., Bader, F. (1981) The prediction of the bulk densities of powder mixtures and its relationship to the filling of hard gelatin capsules. J. Pharm. Pharmacol. 33: 621-626
15. Newton, J. M., Bader, F. (1987) The angle of internal flow as an indicator of filling and drug release properties of capsule formulations. J. Pharm. Pharmacol. 39: 164-168
16. Podczeck, F. (2000) The development of an instrumented tamp filling machine. I. Instrumentation of a Bosch GKF 400S machine and feasibility study. Eur. J. Pharm Sci. 10: 267-274
17. Podczeck, F. (2001) The development of an instrumented tamp filling machine. II. Investigations of plug development and tamping pressure at different filling stations. Eur. J. Pharm Sci. 12: 515-521
18. Podczeck, F., Lee-Amies, G. (1996) The bulk volume changes of powders by granulation and compression with respect to capsule filling. Int. J. Pharm. 142: 97-192
19. Podczeck, F., Miah, Y. (1996) The influence of particle size and shape on the angle of internal friction and the flow factor of unlubricated and lubricated powders. Int. J. Pharm. 144: 187-194
20. Podczeck, F., Sharma, M. (1996) The influence of particle size and shape of components of binary powder mixtures on the maximum volume reduction due to packing. Int. J. Pharm. 137: 41-47
21. Podczeck, F., Newton, J. M. (1999) Powder filling into hard gelatin capsules on a tamp filling machine. Int. J. Pharm. 185: 237-254
22. Podczeck, F., Blackwell, S., Gold, M., Newton, J. M. (1999) The filling of granules into hard gelatin capsules. Int. J. Pharm. 188: 59-69
23. Shah, K., Augsburger, L. L., Small, L. E., G. P. (1983) Instrumentation of a dosing disk automatic capsule filling machine. Pharm. Technol. 7: 42-54
24. Shah, K. B., Augsburger, L. L., Marshall, K. (1986) An investigation into some of the factors influencing plug formation and fill weight in a dosing disk type automatic capsule filling machine. J. Pharm. Sci. 75: 291-296
25. Shah, K. B., Augsburger, L. L., Marshall, K. (1987) Multiple tamping effects on drug dissolution from capsules filled on a dosing-disk type automatic capsule filling machine. J. Pharm. Sci. 76: 639-645
26. Small, L. E., Augsburger, L. L. (1978) Aspects of the lubrication requirements for an automatic capsule filling machine. Drug Dev. Ind. Pharm. 4: 345-372
27. Stewart, A. G., Grant, D. J. W., Newton, J. M. (1979) The release of a model low dose drug (riboflavin) from hard gelatin capsule formulations. J. Pharm. Pharmacol. 31: 1-6
28. Varthalis, S., Pilpel, N. (1976) Anomalies in some properties of powder mixtures. J. Pharm. Pharmacol. 28: 415-419