Antimicrobial effects of a novel Triclosan/zinc citrate dentifrice against mixed culture oral biofilms

International Dental Journal

Volumn 53, Issue 6 SUPPL. 1, 2003, Pages 371-378

  Finney, Michelle ^a,b   Walker, James T ^a   Marsh, Philip D ^a   Brading, Melanie G ^a  

^a Ctr for Appl Microbiol and Res ^*

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Biofilms; Dental caries; Gram negative anaerobes; Periodontal disease; Triclosan; Zinc citrate

Indexed keywords

FLUORIDE; TOOTHPASTE; TRICLOSAN; ZINC CITRATE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIUM ISOLATE; BIOFILM; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG FORMULATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; MOUTH; NONHUMAN; STANDARD; TIME; TOOTH PLAQUE;

EID: 0347185041     PISSN: 00206539     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1875-595x.2003.tb00912.x     Document Type: Article

References (31)

1. Marsh PD, Bradshaw DJ. Microbiological effects of new agents in dentifrices for plaque control. Int Dent J 1993 43: 399-406.
2. Brading M G, Marsh P D. The oral environment; the challenge for antimicrobials in oral care products. Int Dent J 2003 53: 353-362.
3. Costerton JW, Cheng KJ, Geesey GG et al. Bacterial biofilms in nature and disease. Ann Revs Microbio 1987 41: 435-464.
4. Wilson M. Susceptibility of oral bacterial biofilms to antimicrobial agents. J Med Microbiol 1996 44: 79-87.
5. Marsh PD. Microbiological aspects of the chemical control of plaque and gingivitis. J Dent Res 1992 71: 1431-1438.
6. Marsh PD. Plaque as a biofilm: pharmacological principles of drug delivery and action in the sub-and supragingival environment. Oral Diseases 2003 9 (Suppl 1): 16-22.
7. Gilbert RJ, Williams PEO. The oral retention and antiplaque efficacy of Triclosan in human volunteers. Brit J Clin Pharmacol 1987 23: 579-583.
8. Ritchie JA, Jones CL. The inhibition of facultative and obligately anaerobic bacteria by Triclosan. In: Borriello S P, Hardie J M, editors. Anaerobes Today. pp. 240-241. John Wiley & Sons: Chichester, 1988.
9. Nabi N, Mukerjee C, Schmid R et al. In vitro and in vivo studies on triclosan/ PVM/MA copolymer/NaF combination as an antiplaque agent. Am J Dent 1989 2: 197-206.
10. Saxton CA. The effects of a dentifrice containing zinc citrate and 2,4,4′ trichloro-2′-hydroxydiphenyl ether. J Periodontol 1986 57: 555-561.
11. Jenkins S, Addy M, Newcombe R. Toothpastes containing 0.3% and 0.5% triclosan. I Effects on 4-day plaque regrowth. Am J Dent 1989 2: 211-214.
12. Creeth JE, Abraham PJ, Barlow J A et al. Oral delivery and clearance of antiplaque agents from Triclosan-containing dentifrices. Int Dent J 1993 43: 387-397.
13. van der Ouderaa FJ, Cummins D. Delivery systems for agents in supra-and sub-gingival plaque control. J Dent Res 1989 68: 1617-1624.
14. McKee AS, McDermid AS, Ellwood DC, Marsh PD. The establishment of reproducible, complex communities of oral bacteria in the chemostat using defined inocula. J App Bacteriol 1985 59: 263-275.
15. Bradshaw DJ, McKee AS, Marsh PD. The use of defined inocula stored in liquid nitrogen for mixed-culture chemostat studies. J Microbiol Methods 1989 9: 123-128.
16. Coombe RA, Tatevossian A, Wimpenny JWT. Bacterial thin films as in vitro models for dental plaque. In: Frank RM, Leach SA, editors. Surface and Colloid Phenomena in the Oral Cavity pp. 239-249 London: IRL Press, 1981.
17. Bradshaw DJ, McKee AS, Marsh PD. Effects of carbohydrate pulses and pH on population shifts within oral microbial communities in vitro. J Dent Res 1989 68: 1298-1302.
18. Wade WG, Addy M. Antibacterial activity of some triclosan-containing toothpastes and their ingredients. J Periodontol 1992 63: 280-282.
19. Baehni PC, Takeuch Y. Anti-plaque agents in the prevention of biofilm-associated oral diseases. Oral Diseases 2003 9(Suppl.1): 23-29.
20. Marsh PD. Dentifrices containing new agents for the control of plaque and gingivitis: microbiological aspects. J Clin Periodontol 1991 8: 462-467.
21. Marsh PD, Bradshaw DJ. Microbial community aspects of dental plaque. In: Newman H N, Wilson M, editors. Dental plaque revisited: oral biofilms in health and disease pp. 237-253 Cardiff: BioLine, 1999.
22. Marsh PD, Bowden GHW. Microbial community interactions in biofilms. In: Allison D G, Gilbert P, Lappin-Scott H M, et al. editors. Community structure and co-operation in biofilms pp. 167-198. Cambridge: Cambridge University Press, 2000.
23. Kinniment SL, Wimpenny JW, Adams D et al. Development of a steady-state oral microbial biofilm community using the constant-depth film fermenter. Microbiology 1996 142: 631-638.
24. Pratten J, Barnett P, Wilson M. Composition and susceptibility to chlorhexidine of multispecies biofilms of oral bacteria. App Env Microbiol 1998 64: 3515-3519.
25. Pratten J, Smith AW, Wilson M. Response of single species biofilms and microcosm dental plaques to pulsing with chlorhexidine. J Antimicrob Chemother 1998 42: 453-459.
26. Gjermo P, Saxton C A. Antibacterial dentifrices. Clinical data and relevance with emphasis on zinc/triclosan. J Clin Periodontol 1991 18: 468-473.
27. Harrap GJ, Saxton CA, Best JS. Inhibition of plaque growth by zinc salts. J Periodontal Res 1983 18: 634-642.
28. Bradshaw DJ, Marsh PD, Watson GK et al. The effects of Triclosan and zinc citrate, alone and in combination, on a community of oral bacteria grown in vitro. J Dent Res 1993 72: 25-30.
29. Cummins D, Creeth JE. Delivery of antiplaque agents from dentifrices, gels, and mouthwashes. J Dent Res 1992 71: 1439-1449.
30. Afseth J. Some aspects of the dynamics of Cu and Zn retained in plaque as related to their effect on plaque pH. Scand J Dent Res 1983 91: 169-174.
31. Hall PJ, Green AK, Horay CP et al. Plaque antibacterial levels following controlled food intake and use of a toothpaste containing 2% zinc citrate and 0.3% triclosan. Int Dent J 2003 53: 379-384.