Insulin-Mediated Increase in Sympathetic Nerve Activity Is Attenuated by C-Peptide in Diabetic Rats

Experimental Biology and Medicine

Volumn 229, Issue 1, 2004, Pages 80-84

  Rizk, Natalie ^a   Dunbar, Joseph C ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autonomic nervous system insulin; C peptide; Diabetes

Indexed keywords

C PEPTIDE; INSULIN; PROINSULIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; DIABETES MELLITUS; HEART RATE; HORMONE STRUCTURE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SYNTHESIS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; SENSORY NERVE; SYMPATHETIC NERVE; SYMPATHETIC TONE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0347133253     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020422900110     Document Type: Article

References (23)

1. Frost T, Kunt T, Pfutzner A, Beyer J, Wahren J. New aspects on biological activity of C-peptide in IDDM patients. Exp Clin Endocrinol Diabetes 106:270-276, 1998.
2. Horwitz DL, Kuzuya H, Rubenstein AH. Circulating serum C-peptide: a brief review of diagnostic implications. N Engl J Med 295:207-209, 1976.
3. Hoogwerf BJ, Bantle JP, Gaenslen HE, Greenberg BZ, Senske BJ, Francis R, Goetz FC. Infusion of synthetic human C-peptide does not affect plasma glucose, serum insulin, or plasma glucagons in healthy subjects. Metabolism 35:122-125, 1986.
4. Zierath JR, Galuska D, Johansson BL, Wallberg-Henriksson H. Effect of human C-peptide in glucose transport in in vitro incubated human skeletal muscle. Diabetologia 34:899-901, 1991.
5. Ido Y, Vindigni A, Chang K, Stramm L, Chance R, Heath WF, DiMarchi RD, Dicera E, Williamson JR. Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 277:563-566, 1997.
6. Johansson BL, Borg K, Fernqvist-Forbes E, Odergren T, Remahl S, Wahren J. C-peptide improves autonomic nerve function in IDDM patients. Diabetologia 39:687-695, 1996.
7. Johansson BL, Sjoberg, Wahren J. The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients. Diabetologia 35:121-128, 1992.
8. Sima AA, Nathaniel V, Bril V, McEwen T, Greene D. Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin-dependent diabetes, and demonstration of Axo-glial dysjunction in human diabetic neuropathy. J Clin Invest 81:349-364, 1988.
9. Sima AA, Zhang W, Sugimoto, Henry D, Li Z, Wahren, Grunberger G. C-peptide prevents and improves chronic type 1 diabetic polyneuropathy in the BB/Wor rat. Diabetologia 44:889-897, 2001.
10. Sandahl-Christiansen J, Frandsen M, Parving HH. The effect of intravenous insulin infusion on kidney function in insulin-dependent diabetes mellitus. Diabetologia 20:199-204, 1981.
11. Raccah D, Gallice P, Poeget J, Vague P. Hypothesis: low Na/K ATPase activity in red cell membrane, a potential marker of the predisposition to diabetic neuropathy. Diabetes Metab 18:236-241, 1992.
12. Frost T, Kunt T, Pohlmann T, Goitom K, Engelbach M, Beyer J, Pfutzner A. Biological activity of C-peptide on the skin microvasculation in patients with IDDM. J Clin Invest 101:2036-2041, 1998.
13. Dunbar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 46:2040-2043, 1997.
14. Grunberger G, Qiang X, Li ZG, Matthews ST, Sbrissa D, Shisheva A, Sima AA. Molecular basis for the insulinomimetric effects of C-peptide. Diabetologia 44:1247-1357, 2001.
15. Huiqing Lu, Zhengbo D, Tadeusz S, Dunbar JC. The co-existence of insulin-mediated decreased mean arterial pressure and increased sympathetic nerve activity is not mediated by the baroreceptor reflex and differentially by hypoglycemia. Clin Exp Hypertens 20:165-183, 1998.
16. Wright RJ, Schultz KS, Dunbar JC. The effect of ventral medial hypothalamic lesion on insulin induced hypotensive response in normal rats. Acta Diabetol 31:91-97, 1994.
17. Schultz KS, Wright RJ, Dunbar JC. The effect of insulin-induced hypoglycemia, 2-deoxyglucose induced glucopenia and hyperglycemia on cardiovascular tone in normal and diabetic rats. Diabet Res Clin Pract 26:81-89, 1994.
18. Kasuo K. Obesity related hypertension: role of the sympathetic nervous system, insulin and heptin. Curr Hypertens Rep 4:112-118, 2002.
19. Jensen ME, Messina EJ. C-peptide induces a concentration-dependent dilation of skeletal muscle arterioles only in the presence of insulin. Am J Physiol 276:(4 Pt 2)H1223-H1228, 1999.
20. Sima AA, Zhang W, Xu G, Sugimoto K, Guberski D, Yorek MA. A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. Diabetologia 43:786-793, 2000.
21. Mogensen CE, Andersen MJF. Increased kidney size and glomerular filtration rate in untreated juvenile diabetes. Normalisation by insulin treatment. Diabetologia 20:199-204, 1975.
22. Rubenstein AH, Steiner DF, Horwitz DL, Mako ME, Block MB, Starr JI, Kuzuya H, Melani F. Clinical significance of circulating proinsulin and C-peptide. Rec Prog Horm Res 33:435-475, 1977.
23. Toyry JP, Niskanen LK, Mantysaari MJ, Lansimies EA, Haffner SM, Miettinen HJ, Uusitupa MI. Do high proinsulin and C-peptide levels play a role in autonomic nervous dysfunction? Power spectral analysis in patients with NIDD and nondiabetic subjects. Circulation 96:1185-1191, 1997.