-
1
-
-
0027935135
-
General properties and clinical possibilities of new selective inhibitors of catechol-O-methyl transferase
-
Kaakkola S, Gordin A, Mannisto PT. General properties and clinical possibilities of new selective inhibitors of catechol-O-methyl transferase. Gen Pharmacol 1994;25:813-824.
-
(1994)
Gen Pharmacol
, vol.25
, pp. 813-824
-
-
Kaakkola, S.1
Gordin, A.2
Mannisto, P.T.3
-
2
-
-
0028286186
-
Effect of peripheral catechol-O-methyl transferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients
-
Nutt JG, Woodward WR, Beckner RM, et al. Effect of peripheral catechol-O-methyl transferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. Neurology 1994;44:913-919.
-
(1994)
Neurology
, vol.44
, pp. 913-919
-
-
Nutt, J.G.1
Woodward, W.R.2
Beckner, R.M.3
-
3
-
-
0034095886
-
Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease
-
Kaakkola S. Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease. Drugs 2000;59:1233-1250.
-
(2000)
Drugs
, vol.59
, pp. 1233-1250
-
-
Kaakkola, S.1
-
4
-
-
0000182789
-
Entacapone efficacy in Parkinson's disease
-
Abstract
-
Stocchi F, De Pandis MF, Vacca L, Valente M, Brusa L, Ruggieri S. Entacapone efficacy in Parkinson's disease. Mov Disord 2000;15(suppl 3):S127. Abstract.
-
(2000)
Mov Disord
, vol.15
, Issue.SUPPL. 3
-
-
Stocchi, F.1
De Pandis, M.F.2
Vacca, L.3
Valente, M.4
Brusa, L.5
Ruggieri, S.6
-
5
-
-
0034126571
-
Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone
-
Jorga K, Banken L, Fotteler B, Snell P, Steimer JL. Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone. Clin Pharmacol Ther 2000;67:610-620.
-
(2000)
Clin Pharmacol Ther
, vol.67
, pp. 610-620
-
-
Jorga, K.1
Banken, L.2
Fotteler, B.3
Snell, P.4
Steimer, J.L.5
-
6
-
-
0031773064
-
Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations
-
Rinne UK, Larsen JP, Siden A, Worm-Petersen J, and the NOMECOMT Study Group. Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations. Neurology 1998;51:1309-1314.
-
(1998)
Neurology
, vol.51
, pp. 1309-1314
-
-
Rinne, U.K.1
Larsen, J.P.2
Siden, A.3
Worm-Petersen, J.4
-
7
-
-
0037208628
-
Position of COMT inhibition in the treatment of Parkinson's disease
-
Gordin A, Kaakkola S, Teravainen K. Position of COMT inhibition in the treatment of Parkinson's disease. Adv Neurol 2003;91:237-250.
-
(2003)
Adv Neurol
, vol.91
, pp. 237-250
-
-
Gordin, A.1
Kaakkola, S.2
Teravainen, K.3
-
8
-
-
0032547507
-
Tolcapone and fulminant hepatitis
-
Assal F, Spahr L, Hadengue A, Rubbia-Brandt L, Burkhard PR, Rubbici-Brandt L. Tolcapone and fulminant hepatitis. Lancet 1998;352:958.
-
(1998)
Lancet
, vol.352
, pp. 958
-
-
Assal, F.1
Spahr, L.2
Hadengue, A.3
Rubbia-Brandt, L.4
Burkhard, P.R.5
Rubbici-Brandt, L.6
-
9
-
-
0032735154
-
The rise and fall of tolcapone
-
Colosimo C. The rise and fall of tolcapone. J Neurol 1999;246:880-882.
-
(1999)
J Neurol
, vol.246
, pp. 880-882
-
-
Colosimo, C.1
-
10
-
-
0030778373
-
Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients
-
Parkinson Study Group. Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients. Ann Neurol 1997;42:747-755.
-
(1997)
Ann Neurol
, vol.42
, pp. 747-755
-
-
-
11
-
-
0036113588
-
Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal levodopa response: A 6-month randomized placebo-controlled double-blind study in Germany and Austria
-
Poewe WH, Deuschl G, Gordin A, Kultalahti E-R, Leinonen M, and the CELOMEN Study Group. Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal levodopa response: a 6-month randomized placebo-controlled double-blind study in Germany and Austria. Acta Neurol Scand 2002;105:245-255.
-
(2002)
Acta Neurol Scand
, vol.105
, pp. 245-255
-
-
Poewe, W.H.1
Deuschl, G.2
Gordin, A.3
Kultalahti, E.-R.4
Leinonen, M.5
-
12
-
-
0035130228
-
Twelve-month safety of entacapone in patients with Parkinson's disease
-
Myllyla VV, Kultalahti E-R, Haapaniemi H, Leinonen M, and the FILOMEN Study Group. Twelve-month safety of entacapone in patients with Parkinson's disease. Eur J Neurol 2001;8:53-60.
-
(2001)
Eur J Neurol
, vol.8
, pp. 53-60
-
-
Myllyla, V.V.1
Kultalahti, E.-R.2
Haapaniemi, H.3
Leinonen, M.4
-
13
-
-
0041704637
-
Entacapone is beneficial in both fluctuating and non-fluctuating patients with Parkinson's disease. A randomized, placebo-controlled, doubleblind six-month study
-
Brooks DJ, Sagar H, and the UK-Irish Entacapone Study Group. Entacapone is beneficial in both fluctuating and non-fluctuating patients with Parkinson's disease. A randomized, placebo-controlled, doubleblind six-month study. J Neurol Neurosurg Psychiatry 2003;74:1064-1072.
-
(2003)
J Neurol Neurosurg Psychiatry
, vol.74
, pp. 1064-1072
-
-
Brooks, D.J.1
Sagar, H.2
-
14
-
-
0037338132
-
The tolerability and efficacy of entacapone over three years in patients with Parkinson's disease
-
Larsen JP, Worm-Petersen J, Siden A, Gordin A, Reinikainen K, Leinonen M, and the NOMESAFE Study Group. The tolerability and efficacy of entacapone over three years in patients with Parkinson's disease. Eur Neurol 2003;10:137-146.
-
(2003)
Eur Neurol
, vol.10
, pp. 137-146
-
-
Larsen, J.P.1
Worm-Petersen, J.2
Siden, A.3
Gordin, A.4
Reinikainen, K.5
Leinonen, M.6
-
15
-
-
0346576026
-
Entacapone is safe in long-term use in patient's with Parkinson's disease. An Austrian-German open two year safety and one year efficacy study
-
Abstract
-
Poewe W, Deuschl G, Kultalahti, E-R, Reinikainen K, Leinonen M, and the CELOSAFE Study Group. Entacapone is safe in long-term use in patient's with Parkinson's disease. An Austrian-German open two year safety and one year efficacy study. Eur J Neurol 2003;10(suppl 1):241. Abstract.
-
(2003)
Eur J Neurol
, vol.10
, Issue.SUPPL. 1
, pp. 241
-
-
Poewe, W.1
Deuschl, G.2
Kultalahti, E.-R.3
Reinikainen, K.4
Leinonen, M.5
-
16
-
-
0346576026
-
Entacapone is safe in long-term use in patients with Parkinson's disease. A North American open three year safety and one year efficacy study
-
Abstract
-
Waters C, Heikinen H, Holopainen A, Leinonen M, Gordin A, and the SEESAFE Study Group. Entacapone is safe in long-term use in patients with Parkinson's disease. A North American open three year safety and one year efficacy study. Eur J Neurol 2003;10(suppl 1):241. Abstract.
-
(2003)
Eur J Neurol
, vol.10
, Issue.SUPPL. 1
, pp. 241
-
-
Waters, C.1
Heikinen, H.2
Holopainen, A.3
Leinonen, M.4
Gordin, A.5
-
17
-
-
0346092407
-
Tolerability and safety of entacapone in the treatment of Parkinson's disease
-
Abstract
-
Haapaniemi H, Reinikainen K, Leinonen M, et al. Tolerability and safety of entacapone in the treatment of Parkinson's disease. Parkinsonism Relat Disord 2001;7(suppl 1):S57. Abstract.
-
(2001)
Parkinsonism Relat Disord
, vol.7
, Issue.SUPPL. 1
-
-
Haapaniemi, H.1
Reinikainen, K.2
Leinonen, M.3
-
18
-
-
25944436699
-
Predicting the need for levodopa dose reduction after entacapone initiation in PD patients with end-of-dose wearing-off (EODWO)
-
Abstract
-
Reinikainen K, Leinonen M, Isojarvi J, et al. Predicting the need for levodopa dose reduction after entacapone initiation in PD patients with end-of-dose wearing-off (EODWO). Mov Disord 2002;17(suppl 5):P111. Abstract.
-
(2002)
Mov Disord
, vol.17
, Issue.SUPPL. 5
-
-
Reinikainen, K.1
Leinonen, M.2
Isojarvi, J.3
-
20
-
-
0031028464
-
Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease experiencing motor fluctuations: A multicenter, doubleblind, randomized, placebo-controlled trial
-
Tolcapone Fluctuator Study Group I
-
Kurth MC, Adler CH, Hilaire MS, et al. Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease experiencing motor fluctuations: a multicenter, doubleblind, randomized, placebo-controlled trial. Tolcapone Fluctuator Study Group I. Neurology 1997;48:81-87.
-
(1997)
Neurology
, vol.48
, pp. 81-87
-
-
Kurth, M.C.1
Adler, C.H.2
Hilaire, M.S.3
-
21
-
-
0030880324
-
Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuating parkinsonian patients
-
Baas H, Beiske AG, Ghika J, et al. Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuating parkinsonian patients. J Neurol Neurosurg Psychiatry 1997;63:421-428.
-
(1997)
J Neurol Neurosurg Psychiatry
, vol.63
, pp. 421-428
-
-
Baas, H.1
Beiske, A.G.2
Ghika, J.3
-
22
-
-
0030669245
-
Tolcapone improves motor function in parkinsonian patients with the "wearing-off" phenomenon: A double-blind, placebo-controlled, multicenter trial
-
Rajput AH, Martin W, Saint-Hilaire MH, Dorflinger E, Pedder S. Tolcapone improves motor function in parkinsonian patients with the " wearing-off" phenomenon: a double-blind, placebo-controlled, multicenter trial. Neurology 1997;49:1066-1071.
-
(1997)
Neurology
, vol.49
, pp. 1066-1071
-
-
Rajput, A.H.1
Martin, W.2
Saint-Hilaire, M.H.3
Dorflinger, E.4
Pedder, S.5
-
23
-
-
0030833203
-
Tolcapone in stable Parkinson's disease: Efficacy and safety of long-term treatment
-
The Tolcapone Stable Study Group
-
Waters CH, Kurth M, Bailey P, et al. Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. The Tolcapone Stable Study Group. Neurology 1997;49:665-671.
-
(1997)
Neurology
, vol.49
, pp. 665-671
-
-
Waters, C.H.1
Kurth, M.2
Bailey, P.3
-
24
-
-
0028046134
-
COMT inhibition by entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise
-
Illi A, Sundberg S, Koulu M, Scheinin M, Heinavaara S, Gordin A. COMT inhibition by entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise. Int J Clin Pharmacol Ther 1994;32:582-588.
-
(1994)
Int J Clin Pharmacol Ther
, vol.32
, pp. 582-588
-
-
Illi, A.1
Sundberg, S.2
Koulu, M.3
Scheinin, M.4
Heinavaara, S.5
Gordin, A.6
-
26
-
-
0036868497
-
Entacaponeinduced hepatotoxicity and hepatic dysfunction
-
Fisher A, Croft-Baker J, Davis M, Purcell P, McLean AJ. Entacaponeinduced hepatotoxicity and hepatic dysfunction. Mov Disord 2002;17:1362-1365.
-
(2002)
Mov Disord
, vol.17
, pp. 1362-1365
-
-
Fisher, A.1
Croft-Baker, J.2
Davis, M.3
Purcell, P.4
McLean, A.J.5
-
27
-
-
0036868498
-
Entacapone-induced hepatotoxicity and hepatic dysfunction
-
Letter
-
Beck S, Hubble J, Reinikainen K. Entacapone-induced hepatotoxicity and hepatic dysfunction. Mov Disord 2002;17:1397-1399. Letter.
-
(2002)
Mov Disord
, vol.17
, pp. 1397-1399
-
-
Beck, S.1
Hubble, J.2
Reinikainen, K.3
-
28
-
-
0027417592
-
Identification of major metabolites of the catechol-O-methyl transferase inhibitor entacapone in rats and humans
-
Wikberg T, Vuorela A, Ottoila P, Taskinen J. Identification of major metabolites of the catechol-O-methyl transferase inhibitor entacapone in rats and humans. Drug Metab Dispos 1993;21:81-92.
-
(1993)
Drug Metab Dispos
, vol.21
, pp. 81-92
-
-
Wikberg, T.1
Vuorela, A.2
Ottoila, P.3
Taskinen, J.4
-
29
-
-
0032878372
-
Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyl transferase
-
Jorga K, Fotteler B, Heizmann P, Gasser R. Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyl transferase. Br J Clin Pharmacol 1999;48:513-520.
-
(1999)
Br J Clin Pharmacol
, vol.48
, pp. 513-520
-
-
Jorga, K.1
Fotteler, B.2
Heizmann, P.3
Gasser, R.4
-
30
-
-
0031565076
-
Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production
-
Nissinen E, Kaheinen P, Penttila KE, Kaivola J, Linden I-B. Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production. Eur J Pharmacol 1997;340:287-294.
-
(1997)
Eur J Pharmacol
, vol.340
, pp. 287-294
-
-
Nissinen, E.1
Kaheinen, P.2
Penttila, K.E.3
Kaivola, J.4
Linden, I.-B.5
-
31
-
-
0033934604
-
Entacapone and selegiline with L-dopa in patients with Parkinson's disease: An interaction study
-
Lyytinen J, Kaakkola S, Gordin A, Kultalahti E-R, Teravainen H. Entacapone and selegiline with L-dopa in patients with Parkinson's disease: an interaction study. Parkinsonism Relat Disord 2000;6:215-222.
-
(2000)
Parkinsonism Relat Disord
, vol.6
, pp. 215-222
-
-
Lyytinen, J.1
Kaakkola, S.2
Gordin, A.3
Kultalahti, E.-R.4
Teravainen, H.5
-
32
-
-
0029881150
-
Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on hemodynamics and catecholamine metabolism in healthy volunteers
-
Illi A, Sundberg S, Ojala-Karlsson P, Scheinin M, Gordin A. Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: effects on hemodynamics and catecholamine metabolism in healthy volunteers. Clin Pharmacol Ther 1996;59:450-457.
-
(1996)
Clin Pharmacol Ther
, vol.59
, pp. 450-457
-
-
Illi, A.1
Sundberg, S.2
Ojala-Karlsson, P.3
Scheinin, M.4
Gordin, A.5
-
33
-
-
0030476572
-
Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: Lack of interactions
-
Illi A, Sundberg S, Ojala-Karlsson P, Scheinin M, Gordin A. Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: lack of interactions. Eur J Clin Pharmacol 1996;51:273-276.
-
(1996)
Eur J Clin Pharmacol
, vol.51
, pp. 273-276
-
-
Illi, A.1
Sundberg, S.2
Ojala-Karlsson, P.3
Scheinin, M.4
Gordin, A.5
-
34
-
-
0347836167
-
No indication for interactions between entacapone and anti-depressants
-
Abstract
-
Reinikainen K, Karonen T, Haapaniemi H. No indication for interactions between entacapone and anti-depressants. Parkinsonism Relat Disord 2001;7(supp 1):S67. Abstract.
-
(2001)
Parkinsonism Relat Disord
, vol.7
, Issue.SUPPL. 1
-
-
Reinikainen, K.1
Karonen, T.2
Haapaniemi, H.3
|