A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [ 123i]CNS 1261

Nuclear Medicine and Biology

Volumn 31, Issue 2, 2004, Pages 155-164

  Bressan, Rodrigo A ^a   Erlandsson, Kjell ^b   Mulligan, Rachel S ^b   Gunn, Roger N ^c   Cunningham, Vincent J ^d   Owens, Jonathan ^e   Cullum, Ian D ^b   Ell, Peter J ^b   Pilowsky, Lyn S ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

^e WESTERN INFIRMARY   (United Kingdom)

Author keywords

Constant infusion; Dynamic SPET; Equilibrium analysis; Kinetic modeling; NMDA receptors; Volume of distribution

Indexed keywords

CNS 1261; DIZOCILPINE; N (1 NAPHTHYL) N' (3 IODOPHENYL) N METHYLGUANIDINE I 123; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRACER; UNCLASSIFIED DRUG;

ADULT; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; BOLUS INJECTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; FEMALE; HUMAN; HUMAN EXPERIMENT; KINETICS; MALE; NORMAL HUMAN; QUANTITATIVE ANALYSIS; SIDE EFFECT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VENOUS BLOOD;

ADULT; ALGORITHMS; BRAIN; COMPUTER SIMULATION; FEMALE; GUANIDINES; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; INFUSIONS, INTRAVENOUS; IODINE RADIOISOTOPES; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; RADIOISOTOPE DILUTION TECHNIQUE; RADIOPHARMACEUTICALS; RECEPTORS, N-METHYL-D-ASPARTATE; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 1542345728     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2003.08.008     Document Type: Article

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