The molecular basis of retinoid action in tumors

Trends in Molecular Medicine

Volumn 9, Issue 12, 2003, Pages 509-511

  Merino, Ramón ^a   Hurlé, Juan M ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; RETINOIC ACID; RETINOID; RETINOL;

APOPTOSIS; CANCER; CELL DEATH; CYTOTOXICITY; DRUG ACTIVITY; MEDULLOBLASTOMA; METABOLITE; MOLECULAR MECHANICS; PROPHYLAXIS; PROTEIN EXPRESSION; REVIEW;

EID: 0346993145     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2003.10.003     Document Type: Short Survey

References (25)

1. Sun, S-Y. and Lotan, R. (2002) Retinoids and their receptors in cancer development and chemoprevention. Crit. Rev. Oncol. Hematol. 41, 41-55
2. Niles, R.M. (2000) Recent advances in the use of vitamin A (retinoids) in the prevention and treatment of cancer. Nutrition 16, 1084-1089
3. Wei, L.N. (2003) Retinoid receptors and their coregulators. Annu. Rev. Pharmacol. Toxicol. 43, 47-72
4. Hogan, B.L.M. (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 1580-1594
5. Miyazono, K. (2000) Positive and negative regulation of TGF-β signaling. J. Cell Sci. 113, 1101-1109
6. Chimal-Monroy, J. et al. (2003) Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling. Dev. Biol. 257, 292-301
7. Langenfeld, E.M. (2003) The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 24, 1445-1454
8. Arihiro, K. and Inai, K. (2001) Expression of CD31, Met/hepatocyte growth factor receptor and bone morphogenetic protein in bone metastasis of osteosarcoma. Pathol. Int. 51, 100-106
9. Paez-Pereda, M. et al. (2003) Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor. Proc. Natl. Acad. Sci. U. S. A. 100, 1034-1039
10. Pouliot, F. and Labrie, C. (2002) Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein-induced growth arrest in human breast cancer cells. J. Endocrinol. 172, 187-198
11. Hjertner, O. et al. (2001) Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells. Blood 97, 516-522
12. Wach, S. et al. (2001) Overexpression of bone morphogenetic protein-6 (BMP-6) in murine epidermis suppresses skin tumor formation by induction of apoptosis and downregulation of fos/jun family members. Oncogene 20, 7761-7769
13. Hallahan, A.R. et al. (2003) BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nat. Med. 9, 1033-1038
14. Rodriguez-Leon, J. et al. (1999) Retinoic acid regulates programmed cell death through BMP signalling. Nat. Cell Biol. 1, 125-126
15. Ghatpande, S. et al. (2002) Retinoid signaling regulates primitive (yolk sac) hematopoiesis. Blood 99, 2379-2386
16. Glozak, M.A. and Rogers, M.B. (2001) Retinoic acid- and bone morphogenetic protein 4-induced apoptosis in P19 embryonal carcinoma cells requires p27. Exp. Cell Res. 268, 128-138
17. Tallman, M.S. (2002) Acute promyelocytic leukemia: evolving therapeutic strategies. Blood 99, 759-767
18. Altucci, L. (2001) Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL. Nat. Med. 7, 680-686
19. Sharov, A.A. (2003) Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. EMBO J. 22, 2992-3003
20. Caricasole, A. et al. (2000) Bone morphogenetic proteins (BMPs) induce epithelial differentiation of NT2D1 human embryonal carcinoma cells. Int. J. Dev. Biol. 44, 443-450
21. Sumantran, V.N. et al. (2003) BMP-6 and retinoic acid synergistically differentiate the IMR-32 human neuroblastoma cells. Anticancer Res. 23, 1297-1303
22. Fontana, J.A. and Rishi, A.K. (2002) Classical and novel retinoids: their targets in cancer therapy. Leukemia 16, 463-472
23. Sun, S.Y. (2000) Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells. Cancer Res. 60, 7149-7155
24. Shi, Y. and Massague, J. (2003) Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700
25. Yue, J. and Mulder, K.M. (2001) Transforming growth factor-β signal transduction in epithelial cells. Pharmacol. Ther. 91, 1-34