A rational approach to the evaluation and treatment of the infected patient in the intensive care unit

Clinics in Chest Medicine

Volumn 24, Issue 4, 2003, Pages 645-669

  Avecillas, Jaime F ^a   Mazzone, Peter ^a   Arroliga, Alejandro C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; AZITHROMYCIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM; CEFEPIME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; GATIFLOXACIN; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; LINEZOLID; MACROLIDE; MEROPENEM; MONOBACTAM DERIVATIVE; MOXIFLOXACIN; NAFCILLIN; OXACILLIN; OXAZOLIDINONE DERIVATIVE; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TIMENTIN; UNINDEXED DRUG; VANCOMYCIN;

ALGORITHM; ANTIBIOTIC THERAPY; ASSISTED VENTILATION; CLINICAL PRACTICE; CRITICAL ILLNESS; DIAGNOSTIC PROCEDURE; HOSPITAL INFECTION; HUMAN; INFECTION; INTENSIVE CARE UNIT; PNEUMONIA; PRIORITY JOURNAL; REVIEW;

EID: 0346993079     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0272-5231(03)00099-6     Document Type: Review

References (157)

1. Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, Nicolas-Chanoin MH, et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. JAMA 1995;274(8):639-44.
2. Rello J, Paiva JA, Baraibar J, Barcenilla F, Bodi M, Castander D, et al. International Conference for the Development of Consensus on the Diagnosis and Treatment of Ventilator-associated Pneumonia. Chest 2001;120(3):955-70.
3. Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit Care Med 1999;27(5):887-92.
4. Fagon JY, Chastre J, Domart Y, Trouillet JL, Pierre J, Dame C, et al. Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques. Am Rev Respir Dis 1989;139(4):877-84.
5. Torres A, Aznar R, Gatell JM, Jimenez P, Gonzalez J, Ferrer A, et al. Incidence, risk, and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis 1990;142(3):523-8.
6. Jimenez P, Torres A, Rodriguez-Roisin R, de la Bellacasa JP, Aznar R, Gatell JM, et al. Incidence and etiology of pneumonia acquired during mechanical ventilation. Crit Care Med 1989;17(9):882-5.
7. Seidenfeld JJ, Pohl DF, Bell RC, Harris GD, Johanson Jr WG. Incidence, site, and outcome of infections in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1986;134(1):12-6.
8. Fagon JY, Chastre J, Vuagnat A, Trouillet JL, Novara A, Gibert C. Nosocomial pneumonia and mortality among patients in intensive care units. JAMA 1996;275(11):866-9.
9. Rello J, Quintana E, Ausina V, Castella J, Luquin M, Net A, et al. Incidence, etiology, and outcome of nosocomial pneumonia in mechanically ventilated patients. Chest 1991;100(2):439-44.
10. Craven DE, Kunches LM, Kilinsky V, Lichtenberg DA, Make BJ, McCabe WR. Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Respir Dis 1986;133(5):792-6.
11. Rello J, Ollendorf DA, Oster G, Vera-Llonch M, Bellm L, Redman R, et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002;122(6):2115-21.
12. American Thoracic Society. Hospital-acquired pneumonia in adults: diagnosis, assessment of severity, initial antimicrobial therapy, and preventive strategies. A consensus statement. Am J Respir Crit Care Med 1996;153(5):1711-25.
13. Luna CM, Videla A, Mattera J, Vay C, Famiglietti A, Vujacich P, et al. Blood cultures have limited value in predicting severity of illness and as a diagnostic tool in ventilator-associated pneumonia. Chest 1999;116(4):1075-84.
14. Leibovici L, Paul M, Poznanski O, Drucker M, Samra Z, Konigsberger H, et al. Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study. Antimicrob Agents Chemother 1997;41(5):1127-33.
15. Bryan CS, Reynolds KL. Bacteremic nosocomial pneumonia. Analysis of 172 episodes from a single metropolitan area. Am Rev Respir Dis 1984;129(5):668-71.
16. Chendrasekhar A. Are routine blood cultures effective in the evaluation of patients clinically diagnosed to have nosocomial pneumonia? Am Surg 1996;62(5):373-6.
17. Ioanas M, Ferrer R, Angrill J, Ferrer M, Torres A. Microbial investigation in ventilator-associated pneumonia. Eur Respir J 2001;17(4):791-801.
18. Cook D, Mandell L. Endotracheal aspiration in the diagnosis of ventilator-associated pneumonia. Chest 2000;117(4 Suppl 2):195S-7.
19. Marquette CH, Copin MC, Wallet F, Neviere R, Saulnier F, Mathieu D, et al. Diagnostic tests for pneumonia in ventilated patients: prospective evaluation of diagnostic accuracy using histology as a diagnostic gold standard. Am J Respir Crit Care Med 1995;151(6):1878-88.
20. el-Ebiary M, Torres A, Gonzalez J, de la Bellacasa JP, Garcia C, Jimenez de Anta MT, et al. Quantitative cultures of endotracheal aspirates for the diagnosis of ventilator-associated pneumonia. Am Rev Respir Dis 1993;148(6 Pt 1):1552-7.
21. Marquette CH, Georges H, Wallet F, Ramon P, Saulnier F, Neviere R, et al. Diagnostic efficiency of endotracheal aspirates with quantitative bacterial cultures in intubated patients with suspected pneumonia. Comparison with the protected specimen brush. Am Rev Respir Dis 1993;148(1):138-44.
22. Torres A, Martos A, Puig de la Bellacasa J, Ferrer M, el-Ebiary M, Gonzalez J, et al. Specificity of endotracheal aspiration, protected specimen brush, and bronchoalveolar lavage in mechanically ventilated patients. Am Rev Respir Dis 1993;147(4):952-7.
23. Jourdain B, Novara A, Joly-Guillou ML, Dombret MC, Calvat S, Trouillet JL, et al. Role of quantitative cultures of endotracheal aspirates in the diagnosis of nosocomial pneumonia. Am J Respir Crit Care Med 1995;152(1):241-6.
24. Wu CL, Yang D, Wang NY, Kuo HT, Chen PZ. Quantitative culture of endotracheal aspirates in the diagnosis of ventilator-associated pneumonia in patients with treatment failure. Chest 2002;122(2):662-8.
25. Sauaia A, Moore FA, Moore EE, Haenel JB, Kaneer L, Read RA. Diagnosing pneumonia in mechanically ventilated trauma patients: endotracheal aspirate versus bronchoalveolar lavage. J Trauma 1993;35(4):512-7.
26. Morris AJ, Tanner DC, Reller LB. Rejection criteria for endotracheal aspirates from adults. J Clin Microbiol 1993;31(5):1027-9.
27. Timsit JF, Misset B, Francoual S, Goldstein FW, Vaury P, Carlet J. Is protected specimen brush a reproducible method to diagnose ICU-acquired pneumonia? Chest 1993;104(1):104-8.
28. Marquette CH, Herengt F, Mathieu D, Saulnier F, Courcol R, Ramon P. Diagnosis of pneumonia in mechanically ventilated patients. Repeatability of the protected specimen brush. Am Rev Respir Dis 1993;147(1):211-4.
29. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med 2002;165(7):867-903.
30. Montravers P, Fagon JY, Chastre J, Lecso M, Dombret MC, Trouillet JL, et al. Follow-up protected specimen brushes to assess treatment in nosocomial pneumonia. Am Rev Respir Dis 1993;147(1):38-44.
31. Torres A, El-Ebiary M. Bronchoscopic BAL in the diagnosis of ventilator-associated pneumonia. Chest 2000;117(4 Suppl 2):198S-202.
32. Timsit JF, Cheval C, Gachot B, Bruneel F, Wolff M, Carlet J, et al. Usefulness of a strategy based on bronchoscopy with direct examination of bronchoalveolar lavage fluid in the initial antibiotic therapy of suspected ventilator-associated pneumonia. Intensive Care Med 2001;27(4):640-7.
33. Unger M, Sterman D. Bronchoscopy, transthoracic needle aspiration, and related procedures. In: Fishman AP, editor. Fishman's pulmonary diseases and disorders, 3rd edition. Vol. 1. New York: McGraw-Hill; 1998. p. 589-606.
34. Flanagan PG, Jackson SK, Findlay G. Diagnosis of gram negative, ventilator associated pneumonia by assaying endotoxin in bronchial lavage fluid. J Clin Pathol 2001;54(2):107-10.
35. Pham LH, Brun-Buisson C, Legrand P, Rauss A, Verra F, Brochard L, et al. Diagnosis of nosocomial pneumonia in mechanically ventilated patients. Comparison of a plugged telescoping catheter with the protected specimen brush. Am Rev Respir Dis 1991;143(5 Pt 1):1055-61.
36. Jorda R, Parras F, Ibanez J, Reina J, Bergada J, Raurich JM. Diagnosis of nosocomial pneumonia in mechanically ventilated patients by the blind protected telescoping catheter. Intensive Care Med 1993;19(7):377-82.
37. Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD, Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis 1991;143(5 Pt 1):1121-9.
38. Torres A, Puig de la Bellacasa J, Rodriguez-Roisin R, Jimenez de Anta MT, Agusti-Vidal A. Diagnostic value of telescoping plugged catheters in mechanically ventilated patients with bacterial pneumonia using the Metras catheter. Am Rev Respir Dis 1988;138(1):117-20.
39. Rouby JJ, Rossignon MD, Nicolas MH, Martin de Lassale E, Cristin S, Grosset J, et al. A prospective study of protected bronchoalveolar lavage in the diagnosis of nosocomial pneumonia. Anesthesiology 1989;71(5):679-85.
40. Rouby JJ, Martin De Lassale E, Poete P, Nicolas MH, Bodin L, Jarlier V, et al. Nosocomial bronchopneumonia in the critically ill. Histologic and bacteriologic aspects. Am Rev Respir Dis 1992;146(4):1059-66.
41. Leal-Noval SR, Alfaro-Rodriguez E, Murillo-Cabeza F, Garnacho-Montero J, Rey-Perez J, Munoz-Sanchez MA. Diagnostic value of the blind brush in mechanically ventilated patients with nosocomial pneumonia. Intensive Care Med 1992;18(7):410-4.
42. Kollef MH, Bock KR, Richards RD, Heams ML. The safety and diagnostic accuracy of minibronchoalveolar lavage in patients with suspected ventilator-associated pneumonia. Ann Intern Med 1995;122(10):743-8.
43. Lambert RS, Vereen LE, George RB. Comparison of tracheal aspirates and protected brush catheter specimens for identifying pathogenic bacteria in mechanically ventilated patients. Am J Med Sci 1989;297(6):377-82.
44. Pugin J, Suter PM. Diagnostic bronchoalveolar lavage in patients with pneumonia produces sepsis-like systemic effects. Intensive Care Med 1992;18(1):6-10.
45. Montravers P, Gauzit R, Dombret MC, Blanchet F, Desmonts JM. Cardiopulmonary effects of bronchoalveolar lavage in critically ill patients. Chest 1993;104(5):1541-7.
46. Krueger JJ, Sayre VA, Karetzky MS. Bronchoalveolar lavage-induced pneumothorax. Chest 1988;94(2):440-1.
47. Strumpf IJ, Feld MK, Cornelius MJ, Keogh BA, Crystal RG. Safety of fiberoptic bronchoalveolar lavage in evaluation of interstitial lung disease. Chest 1981;80(3):268-71.
48. Steinberg KP, Mitchell DR, Maunder RJ, Milberg JA, Whitcomb ME, Hudson LD. Safety of bronchoalveolar lavage in patients with adult respiratory distress syndrome. Am Rev Respir Dis 1993;148(3):556-61.
49. Corley DE, Kirtland SH, Winterbauer RH, Hammar SP, Dail DH, Bauermeister DE, et al. Reproducibility of the histologic diagnosis of pneumonia among a panel of four pathologists: analysis of a gold standard. Chest 1997;112(2):458-65.
50. Fagon JY, Chastre J, Wolff M, Gervais C, Parer-Aubas S, Stephan F, et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia. A randomized trial. Ann Intern Med 2000;132(8):621-30.
51. Sole Violan J, Fernandez JA, Benitez AB, Cardenosa Cendrero JA, Rodriguez de Castro F. Impact of quantitative invasive diagnostic techniques in the management and outcome of mechanically ventilated patients with suspected pneumonia. Crit Care Med 2000;28(8):2737-41.
52. Sanchez-Nieto JM, Torres A, Garcia-Cordoba F, El-Ebiary M, Carrillo A, Ruiz J, et al. Impact of invasive and noninvasive quantitative culture sampling on outcome of ventilator-associated pneumonia: a pilot study. Am J Respir Crit Care Med 1998;157(2):371-6.
53. Ruiz M, Torres A, Ewig S, Marcos MA, Alcon A, Lledo R, et al. Noninvasive versus invasive microbial investigation in ventilator-associated pneumonia: evaluation of outcome. Am J Respir Crit Care Med 2000;162(1):119-25.
54. George DL, Falk PS, Wunderink RG, Leeper Jr KV, Meduri GU, Steere EL, et al. Epidemiology of ventilator-acquired pneumonia based on protected bronchoscopic sampling. Am J Respir Crit Care Med 1998;158(6):1839-47.
55. Timsit JF, Chevret S, Valcke J, Misset B, Renaud B, Goldstein FW, et al. Mortality of nosocomial pneumonia in ventilated patients: influence of diagnostic tools. Am J Respir Crit Care Med 1996;154(1):116-23.
56. Meduri GU, Reddy RC, Stanley T, El-Zeky F. Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling. Am J Respir Crit Care Med 1998;158(3):870-5.
57. Dore P, Robert R, Grollier G, Rouffineau J, Lanquetot H, Charriere JM, et al. Incidence of anaerobes in ventilator-associated pneumonia with use of a protected specimen brush. Am J Respir Crit Care Med 1996;153(4 Pt 1):1292-8.
58. Marik PE, Careau P. The role of anaerobes in patients with ventilator-associated pneumonia and aspiration pneumonia: a prospective study. Chest 1999;115(1):178-83.
59. Baker AM, Meredith JW, Haponik EF. Pneumonia in intubated trauma patients. Microbiology and outcomes. Am J Respir Crit Care Med 1996;153(1):343-9.
60. Combes A, Figliolini C, Trouillet JL, Kassis N, Wolff M, Gibert C, et al. Incidence and outcome of polymicrobial ventilator-associated pneumonia. Chest 2002;121(5):1618-23.
61. Rello J, Ausina V, Ricart M, Puzo C, Quintana E, Net A, et al. Risk factors for infection by Pseudomonas aeruginosa in patients with ventilator-associated pneumonia. Intensive Care Med 1994;20(3):193-8.
62. Baraibar J, Correa H, Mariscal D, Gallego M, Valles J, Rello J. Risk factors for infection by Acinetobacter baumannii in intubated patients with nosocomial pneumonia. Chest 1997;112(4):1050-4.
63. Rello J, Torres A, Ricart M, Valles J, Gonzalez J, Artigas A, et al. Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes. Am J Respir Crit Care Med 1994;150(6 Pt 1):1545-9.
64. Carratala J, Gudiol F, Pallares R, Dorca J, Verdaguer R, Ariza J, et al. Risk factors for nosocomial Legionella pneumophila pneumonia. Am J Respir Crit Care Med 1994;149(3 Pt 1):625-9.
65. Fridkin SK, Steward CD, Edwards JR, Pryor ER, McGowan Jr JE, Archibald LK, et al. Surveillance of antimicrobial use and antimicrobial resistance in United States hospitals: project ICARE phase 2. Project Intensive Care Antimicrobial Resistance Epidemiology (ICARE) hospitals. Clin Infect Dis 1999;29(2):245-52.
66. Trouillet JL, Chastre J, Vuagnat A, Joly-Guillou ML, Combaux D, Dombret MC, et al. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 1998;157(2):531-9.
67. Rello J, Sa-Borges M, Correa H, Leal SR, Baraibar J. Variations in etiology of ventilator-associated pneumonia across four treatment sites: implications for antimicrobial prescribing practices. Am J Respir Crit Care Med 1999;160(2):608-13.
68. Trouillet JL, Vuagnat A, Combes A, Kassis N, Chastre J, Gibert C. Pseudomonas aeruginosa ventilator-associated pneumonia: comparison of episodes due to piperacillin-resistant versus piperacillin-susceptible organisms. Clin Infect Dis 2002;34(8):1047-54.
69. Hayon J, Figliolini C, Combes A, Trouillet JL, Kassis N, Dombret MC, et al. Role of serial routine microbiologic culture results in the initial management of ventilator-associated pneumonia. Am J Respir Crit Care Med 2002;165(1):41-6.
70. Pujol M, Pena C, Pallares R, Ariza J, Ayats J, Dominguez MA, et al. Nosocomial Staphylococcus aureus bacteremia among nasal carriers of methicillin-resistant and methicillin-susceptible strains. Am J Med 1996;100(5):509-16.
71. von Eiff C, Becker K, Machka K, Stammer H, Peters G. Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med 2001;344(1):11-6.
72. Ibrahim EH, Ward S, Sherman G, Schaiff R, Fraser VJ, Kollef MH. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med 2001;29(6):1109-15.
73. Ibrahim EH, Ward S, Sherman G, Kollef MH. A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting. Chest 2000;117(5):1434-42.
74. Arroliga ME, Wagner W, Bobek MB, Hoffman-Hogg L, Gordon SM, Arroliga AC. A pilot study of penicillin skin testing in patients with a history of penicillin allergy admitted to a medical ICU. Chest 2000;118(4):1106-8.
75. Hilf M, Yu VL, Sharp J, Zuravleff JJ, Korvick JA, Muder RR. Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients. Am J Med 1989;87(5):540-6.
76. Korvick JA, Bryan CS, Farber B, Beam Jr TR, Schenfeld L, Muder RR, et al. Prospective observational study of Klebsiella bacteremia in 230 patients: outcome for antibiotic combinations versus monotherapy. Antimicrob Agents Chemother 1992;36(12):2639-44.
77. Gribble MJ, Chow AW, Naiman SC, Smith JA, Bowie WR, Sacks SL, et al. Prospective randomized trial of piperacillin monotherapy versus carboxypenicillin-aminoglycoside combination regimens in the empirical treatment of serious bacterial infections. Antimicrob Agents Chemother 1983;24(3):388-93.
78. Cometta A, Baumgartner JD, Lew D, Zimmerli W, Pittet D, Chopart P, et al. Prospective randomized comparison of imipenem monotherapy with imipenem plus netilmicin for treatment of severe infections in nonneutropenic patients. Antimicrob Agents Chemother 1994;38(6):1309-13.
79. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002;122(1):262-8.
80. Fink MP, Snydman DR, Niederman MS, Leeper Jr KV, Johnson RH, Heard SO, et al. Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin. The Severe Pneumonia Study Group. Antimicrob Agents Chemother 1994;38(3):547-57.
81. Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 1993;94(3):281-8.
82. Silver DR, Cohen IL, Weinberg PF. Recurrent Pseudomonas aeruginosa pneumonia in an intensive care unit. Chest 1992;101(1):194-8.
83. Singh N, Rogers P, Atwood CW, Wagener MM, Yu VL. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 2000;162(2 Pt 1):505-11.
84. Maki DG, Goldman DA, Rhame FS. Infection control in intravenous therapy. Ann Intern Med 1973;79(6):867-87.
85. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality. JAMA 1994;271(20):1598-601.
86. Martin MA, Pfaller MA, Wenzel RP. Coagulase-negative staphylococcal bacteremia. Mortality and hospital stay. Ann Intern Med 1989;110(1):9-16.
87. Arnow PM, Quimosing EM, Beach M. Consequences of intravascular catheter sepsis. Clin Infect Dis 1993;16(6):778-84.
88. Raad I, Darouiche R, Dupuis J, Abi-Said D, Gabrielli A, Hachem R, et al. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections. A randomized, double-blind trial. The Texas Medical Center Catheter Study Group. Ann Intern Med 1997;127(4):267-74.
89. Maki DG, Stolz SM, Wheeler S, Mermel LA. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter. A randomized, controlled trial. Ann Intern Med 1997;127(4):257-66.
90. Bryant JK, Strand CL. Reliability of blood cultures collected from intravascular catheter versus venipuncture. Am J Clin Pathol 1987;88(1):113-6.
91. Norberg A, Christopher NC, Ramundo ML, Bower JR, Berman SA. Contamination rates of blood cultures obtained by dedicated phlebotomy vs intravenous catheter. JAMA 2003;289(6):726-9.
92. Martinez JA, DesJardin JA, Aronoff M, Supran S, Nasraway SA, Snydman DR. Clinical utility of blood cultures drawn from central venous or arterial catheters in critically ill surgical patients. Crit Care Med 2002;30(1):7-13.
93. Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med 1977;296(23):1305-9.
94. Widmer AF. Central venous catheters. In: Seifert H, Jansen B, Farr BM, editors. Catheter-related infections. 1st edition. New York: Marcel Dekker; 1997. p. 183-215.
95. Hnatiuk OW, Pike J, Stoltzfus D, Lane W. Value of bedside plating of semiquantitative cultures for diagnosis of central venous catheter-related infections in ICU patients. Chest 1993;103(3):896-9.
96. Schmitt SK, Knapp C, Hall GS, Longworth DL, McMahon JT, Washington JA. Impact of chlorhexidine-silver sulfadiazine-impregnated central venous catheters on in vitro quantitation of catheter-associated bacteria. J Clin Microbiol 1996;34(3):508-11.
97. Quilici N, Audibert G, Conroy MC, Bollaert PE, Guillemin F, Welfringer P, et al. Differential quantitative blood cultures in the diagnosis of catheter-related sepsis in intensive care units. Clin Infect Dis 1997;25(5):1066-70.
98. Blot F, Schmidt E, Nitenberg G, Tancrede C, Leclercq B, Laplanche A, et al. Earlier positivity of central-venous- versus peripheral-blood cultures is highly predictive of catheter-related sepsis. J Clin Microbiol 1998;36(1):105-9.
99. Smith RL, Meixler SM, Simberkoff MS. Excess mortality in critically ill patients with nosocomial bloodstream infections. Chest 1991;100(1):164-7.
100. Mermel LA, Farr BM, Sherertz RJ, Raad II, O'Grady N, Harris JS, et al. Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis 2001;32(9):1249-72.
101. Pettigrew RA, Lang SD, Haydock DA, Parry BR, Bremner DA, Hill GL. Catheter-related sepsis in patients on intravenous nutrition: a prospective study of quantitative catheter cultures and guidewire changes for suspected sepsis. Br J Surg 1985;72(1):52-5.
102. Mermel LA, Maki DG. Infectious complications of Swan-Ganz pulmonary artery catheters and peripheral arterial catheters. In: Seifert H, Jansen B, Farr BM, editors. Catheter-related infections. New York: Marcel Dekker; 1997. p. 259-305.
103. Armstrong CW, Mayhall CG, Miller KB, Newsome Jr HH, Sugerman HJ, Dalton HP, et al. Prospective study of catheter replacement and other risk factors for infection of hyperalimentation catheters. J Infect Dis 1986;154(5):808-16.
104. Jernigan JA, Farr BM. Short-course therapy of catheter-related Staphylococcus aureus bacteremia: a meta-analysis. Ann Intern Med 1993;119(4):304-11.
105. Lecciones JA, Lee JW, Navarro EE, Witebsky FG, Marshall D, Steinberg SM, et al. Vascular catheter-associated fungemia in patients with cancer: analysis of 155 episodes. Clin Infect Dis 1992;14(4):875-83.
106. Rex JH, Bennett JE, Sugar AM, Pappas PG, Serody J, Edwards JE, et al. Intravascular catheter exchange and duration of candidemia. NIAID Mycoses Study Group and the Candidemia Study Group. Clin Infect Dis 1995;21(4):994-6.
107. Raad I, Davis S, Khan A, Tarrand J, Elfing L, Bodey GP. Impact of central venous catheter removal on the recurrence of catheter-related coagulase-negative staphylococcal bacteremia. Infect Control Hosp Epidemiol 1992;13(4):215-21.
108. Raad II, Sabbagh MF. Optimal duration of therapy for catheter-related Staphylococcus aureus bacteremia: a study of 55 cases and review. Clin Infect Dis 1992;14(1):75-82.
109. Rosen AB, Fowler Jr VG, Corey GR, Downs SM, Biddle AK, Li J, et al. Cost-effectiveness of transesophageal echocardiography to determine the duration of therapy for intravascular catheter-associated Staphylococcus aureus bacteremia. Ann Intern Med 1999;130(10):810-20.
110. Herrmann M, Peters G. Catheter-associated infections caused by coagulase-negative staphylococci. Clinical and biological aspects. In: Seifert H, Jansen B, Farr BM, editors. Catheter-related infections. 1st edition. New York: Marcel Dekker; 1997. p. 79-109.
111. Dugdale DC, Ramsey PG. Staphylococcus aureus bacteremia in patients with Hickman catheters. Am J Med 1990;89(2):137-41.
112. Messing B, Peitra-Cohen S, Debure A, Beliah M, Bernier JJ. Antibiotic-lock technique: a new approach to optimal therapy for catheter-related sepsis in home-parenteral nutrition patients. JPEN J Parenter Enteral Nutr 1988;12(2):185-9.
113. Gaillard JL, Merlino R, Pajot N, Goulet O, Fauchere JL, Ricour C, et al. Conventional and nonconventional modes of vancomycin administration to decontaminate the internal surface of catheters colonized with coagulase-negative staphylococci. JPEN J Parenter Enteral Nutr 1990;14(6):593-7.
114. Kronberg FG, Goodwin Jr WJ. Sinusitis in intensive care unit patients. Laryngoscope 1985;95(8):936-8.
115. Rouby JJ, Laurent P, Gosnach M, Cambau E, Lamas G, Zouaoui A, et al. Risk factors and clinical relevance of nosocomial maxillary sinusitis in the critically ill. Am J Respir Crit Care Med 1994;150(3):776-83.
116. Bach A, Boehrer H, Schmidt H, Geiss HK. Nosocomial sinusitis in ventilated patients. Nasotracheal versus orotracheal intubation. Anaesthesia 1992;47(4):335-9.
117. George DL, Falk PS, Umberto Meduri G, Leeper Jr KV, Wunderink RG, Steere EL, et al. Nosocomial sinusitis in patients in the medical intensive care unit: a prospective epidemiological study. Clin Infect Dis 1998;27(3):463-70.
118. Hansen M, Poulsen MR, Bendixen DK, Hartmann-Andersen F. Incidence of sinusitis in patients with nasotracheal intubation. Br J Anaesth 1988;61(2):231-2.
119. Fassoulaki A, Pamouktsoglou P. Prolonged nasotracheal intubation and its association with inflammation of paranasal sinuses. Anesth Analg 1989;69(1):50-2.
120. Vandenbussche T, De Moor S, Bachert C, Van Cauwenberge P. Value of antral puncture in the intensive care patient with fever of unknown origin. Laryngoscope 2000;110(10 Pt 1):1702-6.
121. Kountakis SE, Burke L, Rafie JJ, Bassichis B, Maillard AA, Stiernberg CM. Sinusitis in the intensive care unit patient. Otolaryngol Head Neck Surg 1997;117(4):362-6.
122. Holzapfel L, Chevret S, Madinier G, Ohen F, Demingeon G, Coupry A, et al. Influence of long-term oroor nasotracheal intubation on nosocomial maxillary sinusitis and pneumonia: results of a prospective, randomized, clinical trial. Crit Care Med 1993;21(8):1132-8.
123. Holzapfel L, Chastang C, Demingeon G, Bohe J, Piralla B, Coupry A. A randomized study assessing the systematic search for maxillary sinusitis in nasotracheally mechanically ventilated patients. Influence of nosocomial maxillary sinusitis on the occurrence of ventilator-associated pneumonia. Am J Respir Crit Care Med 1999;159(3):695-701.
124. Michelson A, Schuster B, Kamp HD. Paranasal sinusitis associated with nasotracheal and orotracheal long-term intubation. Arch Otolaryngol Head Neck Surg 1992;118(9):937-9.
125. Desmond P, Raman R, Idikula J. Effect of nasogastric tubes on the nose and maxillary sinus. Crit Care Med 1991;19(4):509-11.
126. Bert F, Lambert-Zechovsky N. Pathogens responsible for concurrent sinusitis and pneumonia in intensive care unit patients. Infection 1996;24(1):52-3.
127. Zinreich SJ. Rhinosinusitis: radiologic diagnosis. Otolaryngol Head Neck Surg 1997;117(3 Pt 2):S27-34.
128. O'Reilly MJ, Reddick EJ, Black W, Carter PL, Erhardt J, Fill W, et al. Sepsis from sinusitis in nasotracheally intubated patients. A diagnostic dilemma. Am J Surg 1984;147(5):601-4.
129. Puidupin M, Guiavarch M, Paris A, Caroff P, Boutin JP, Le Bivic T, et al. B-mode ultrasound in the diagnosis of maxillary sinusitis in intensive care unit. Intensive Care Med 1997;23(11):1174-5.
130. Hilbert G, Vargas F, Valentino R, Gruson D, Chene G, Bebear C, et al. Comparison of B-mode ultrasound and computed tomography in the diagnosis of maxillary sinusitis in mechanically ventilated patients. Crit Care Med 2001;29(7):1337-42.
131. Westergren V, Lundblad L, Forsum U. Ventilator-associated sinusitis: antroscopic findings and bacteriology when excluding contaminants. Acta Otolaryngol 1998;118(4):574-80.
132. Casiano RR, Cohn S, Villasuso III E, Brown M, Memari F, Barquist E, et al. Comparison of antral tap with endoscopically directed nasal culture. Laryngoscope 2001;111(8):1333-7.
133. Kountakis SE, Skoulas IG. Middle meatal vs antral lavage cultures in intensive care unit patients. Otolaryngol Head Neck Surg 2002;126(4):377-81.
134. Talmor M, Li P, Barie PS. Acute paranasal sinusitis in critically ill patients: guidelines for prevention, diagnosis, and treatment. Clin Infect Dis 1997;25(6):1441-6.
135. Meduri GU, Mauldin GL, Wunderink RG, Leeper Jr KV, Jones CB, Tolley E, et al. Causes of fever and pulmonary densities in patients with clinical manifestations of ventilator-associated pneumonia. Chest 1994;106(1):221-35.
136. Salord F, Gaussorgues P, Marti-Flich J, Sirodot M, Allimant C, Lyonnet D, et al. Nosocomial maxillary sinusitis during mechanical ventilation: a prospective comparison of orotracheal versus the nasotracheal route for intubation. Intensive Care Med 1990;16(6):390-3.
137. Le Moal G, Lemerre D, Grollier G, Desmont C, Klossek JM, Robert R. Nosocomial sinusitis with isolation of anaerobic bacteria in ICU patients. Intensive Care Med 1999;25(10):1066-71.
138. Ramadan HH, Owens RM, Tiu C, Wax MK. Role of antral puncture in the treatment of sinusitis in the intensive care unit. Otolaryngol Head Neck Surg 1998;119(4):381-4.
139. Bryan CS, Reynolds KL. Hospital-acquired bacteremic urinary tract infection: epidemiology and outcome. J Urol 1984;132(3):494-8.
140. Kreger BE, Craven DE, Carling PC, McCabe WR. Gram-negative bacteremia. III. Reassessment of etiology, epidemiology and ecology in 612 patients. Am J Med 1980;68(3):332-43.
141. Green MS, Rubinstein E, Amit P. Estimating the effects of nosocomial infections on the length of hospitalization. J Infect Dis 1982;145(5):667-72.
142. Givens CD, Wenzel RP. Catheter-associated urinary tract infections in surgical patients: a controlled study on the excess morbidity and costs. J Urol 1980;124(5):646-8.
143. Laupland KB, Zygun DA, Davies HD, Church DL, Louie TJ, Doig CJ. Incidence and risk factors for acquiring nosocomial urinary tract infection in the critically ill. J Crit Care 2002;17(1):50-7.
144. Barsic B, Beus I, Marton E, Himbele J, Klinar I. Nosocomial infections in critically ill infectious disease patients: results of a 7-year focal surveillance. Infection 1999;27(1):16-22.
145. Warren JW, Damron D, Tenney JH, Hoopes JM, Deforge B, Muncie Jr HL. Fever, bacteremia, and death as complications of bacteriuria in women with long-term urethral catheters. J Infect Dis 1987;155(6):1151-8.
146. Jain P, Parada JP, David A, Smith LG. Overuse of the indwelling urinary tract catheter in hospitalized medical patients. Arch Intern Med 1995;155(13):1425-9.
147. Abraham E, Wunderink R, Silverman H, Perl TM, Nasraway S, Levy H, et al. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA 1995;273(12):934-41.
148. Abraham E, Anzueto A, Gutierrez G, Tessler S, San Pedro G, Wunderink R, et al. Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group. Lancet 1998;351(9107):929-33.
149. Cohen J, Carlet J. INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996;24(9):1431-40.
150. Rosser CJ, Bare RL, Meredith JW. Urinary tract infections in the critically ill patient with a urinary catheter. Am J Surg 1999;177(4):287-90.
151. Krieger JN, Kaiser DL, Wenzel RP. Urinary tract etiology of bloodstream infections in hospitalized patients. J Infect Dis 1983;148(1):57-62.
152. Stamm WE, Martin SM, Bennett JV. Epidemiology of nosocomial infection due to Gram-negative bacilli: aspects relevant to development and use of vaccines. J Infect Dis 1977;136(Suppl):S151-60.
153. Stamm WE. Nosocomial urinary tract infections. In: Bennett JV, Brachman PS, editors. Hospital infections. 3rd edition. Boston: Little Brown; 1992. p. 597-610.
154. Falagas ME, Gorbach SL. Practice guidelines: urinary tract infections. Infect Dis Clin Pract 1995;4(4):241-56.
155. Johnson JR, Vincent LM, Wang K, Roberts PL, Stamm WE. Renal ultrasonographic correlates of acute pyelonephritis. Clin Infect Dis 1992;14(1):15-22.
156. Ayeni O, Riederer KM, Wilson FM, Khatib R. Clinicians' reaction to positive urine culture for Candida organisms. Mycoses 1999;42(4):285-9.
157. Fisher JF, Newman CL, Sobel JD. Yeast in the urine: solutions for a budding problem. Clin Infect Dis 1995;20(1):183-9.