Cutaneous paraneoplastic syndromes in dogs and cats: A review of the literature

Veterinary Dermatology

Volumn 14, Issue 6, 2003, Pages 279-296

  Turek, Michelle M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Alopecia; Cat; Dog; Exfoliative dermatitis; Feminization; Nodular dermatofibrosis; Paraneoplastic; Pemphigus; Skin; Superficial necrolytic dermatitis

Indexed keywords

ACANTHOSIS NIGRICANS; ACUTE FEBRILE NEUTROPHILIC DERMATOSIS; ALOPECIA; AMYLOIDOSIS; CANCER DIAGNOSIS; CAT; CLINICAL FEATURE; DERMATITIS; DERMATOMYOSITIS; DIAGNOSTIC TEST; DOG; ERYTHEMA; ERYTHRODERMA; ERYTHROMELALGIA; EXFOLIATIVE DERMATITIS; FEMINIZATION; HISTOPATHOLOGY; INCIDENCE; KERATOSIS; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PAPILLOMATOSIS; PARANEOPLASTIC SYNDROME; PEMPHIGUS; RETICULOHISTIOCYTOSIS; REVIEW; SKIN DISEASE; SKIN FIBROSIS; TESTIS TUMOR; THYMOMA;

ANIMALS; CAT DISEASES; CATS; DOG DISEASES; DOGS; HUMANS; NEOPLASMS; PARANEOPLASTIC SYNDROMES; SKIN DISEASES;

ANIMALIA; CANIS FAMILIARIS; FELIDAE; FELIS CATUS; PEMPHIGUS;

EID: 0346969742     PISSN: 09594493     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3164.2003.00346.x     Document Type: Review

References (101)

1. Nathanson, L., Hall, T.C. Introduction: paraneoplastic syndromes. Seminars in Oncology 1997; 24: 265-8.
2. Fox, L.E. The paraneoplastic disorders. In: Bonagura, J.D., Kirk, R.W, eds. Kirk's Current Veterinary Therapy XII: Small Animal Practice. W.B. Saunders, Philadelphia, 1995: 530-42.
3. Scott, D.W., Miller, W.H., Griffin, C.E. Muller and Kirk's Small Animal Dermatology, 6th edn. W.B. Saunders, Philadelphia, 2001.
4. Weiss, P., O'Rourke, M.E. Cutaneous paraneoplastic syndromes. Clinical Journal of Oncology Nursing 2000; 4: 257-62.
5. Sabir, S., James, W.D., Schuchter, L.M. Cutaneous manifestations of cancer. Current Opinion in Oncology 1999; 11: 139-44.
6. Politi, Y., Ophir, J., Brenner, S. Cutaneous paraneoplastic syndromes. Acta Dermato-Venereologica 1993; 73: 161-70.
7. Cohen, P.R., Kurzrock, R. Mucocutaneous paraneoplastic syndromes. Seminars in Oncology 1997; 24 (3): 334-59.
8. Kurzrock, R., Cohen, P.R. Cutaneous paraneoplastic syndromes in solid tumors. American Journal of Medicine 1995; 99: 662-71.
9. Kurzrock, R., Cohen, P.R. Mucocutaneous paraneoplastic manifestations of hematologic malignancies. American Journal of Medicine 1995; 99: 207-16.
10. Ellis, D.L., Kafka, S.P., Chow, J.C. et al. Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trélat, and multiple acrochordons: a possible role for alpha-transforming growth factor in cutaneous paraneoplastic syndromes. New England Journal of Medicine 1987; 317 (25): 1582-7.
11. Wilgenbus, K., Lentner, A., Kuckelkorn, R. et al. Further evidence that acanthosis nigricans maligna is linked to enhanced secretion by the tumour of transforming growth factor alpha. Archives of Dermatological Research 1992; 284 (25): 266-70.
12. Koyama, S., Kazuho, I., Sato, M. et al. Transforming growth factor-alpha (TGFα)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGFα in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus. Journal of Gastroenterology 1997; 32: 71-7.
13. Chosidow, O., Bécherel, P.-A., Piette, P.-C. et al. Tripe palms associated with systemic mastocytosis: the role of transforming growth factor-α and efficacy of interferon-alfa. British Journal of Dermatology 1998; 138: 698-703.
14. Bolognia, J.L., Brewer, Y.P., Cooper, D.L. Bazex syndrome (acrokeratosis paraneoplastica): an analytic review. Medicine 1991; 70 (4): 269-80.
15. 14a. Braverman, I.M. Skin manifestations of internal malignancy. Clinics in Geriatric Medicine 2002; 18 (1): 1-19.
16. Hashimoto, K. Regulation of keratinocyte function by growth factors. Journal of Dermatological Science 2000; 24 (Suppl. 1): S46-S50.
17. Mendelsohn, J. The epidermal growth factor receptor as a target for cancer therapy. Endocrine-Related Cancer 2001; 8: 3-9.
18. Normanno, N., Bianco, C., De Luca, A. et al. The role of EGF-related peptides in tumor growth. Frontiers in Bioscience 2001; 6: D685-707.
19. 17a. Agarwala, S.S. Paraneoplastic syndromes. Medical Clinics of North America 1996; 80 (1): 173-84.
20. Matsuoka, L.Y., Goldman, J.G., Wortsman, J. et al. Antibodies against the insulin receptor in paraneoplastic acanthosis nigricans. American Journal of Medicine 1987; 82: 1253-6.
21. Brooks, D.G., Campbell, K.L., Dennis, J.S. et al. Pancreatic paraneoplastic alopecia in three cats. Journal of the American Animal Hospital Association 1994; 30: 557-63.
22. Pascal-Tenorio, A., Olivry, T., Gross, T.L. et al. Paraneoplastic alopecia associated with internal malignancies in the cat. Veterinary Dermatology 1997; 8: 47-52.
23. Godfrey, D.R. A case of feline paraneoplastic alopecia with secondary Malassezia-associated dermatitis. Journal of Small Animal Practice 1998; 39: 394-6.
24. Tasker, S., Griffon, D.J., Nuttall, T.J. et al. Resolution of paraneoplastic alopecia following surgical removal of a pancreatic carcinoma in a cat. Journal of Small Animal Practice 1999; 40: 16-19.
25. Mauldin, E.A., Morris, D.O., Goldschmidt, M.H. Retrospective study. The presence of Malassezia in feline skin biopsies. A clinicopathological study. Veterinary Dermatology 2002; 13: 7-13.
26. Barrs, V.R., Martin, P., France, M. et al. What is your diagnosis? Journal of Small Animal Practice 1999; 40: 594-6.
27. Withrow, S.J. Exocrine cancer of the pancreas. In: Withrow, S.J., MacEwen, E.G., eds. Small Animal Clinical Oncology, 3rd edn. WB. Saunders, Philadelphia, 2001, 321-3.
28. Thamm, D.H. Hepatobiliary tumors. In: Withrow, S.J., MacEwen, E.G., eds. Small Animal Clinical Oncology, 3rd edn. WB. Saunders, Philadelphia, 2001, 327-34.
29. Scott, D.W., Yager, J.A., Johnston, K.M. Exfoliative dermatitis in association with thymoma in three cats. Feline Practice 1995; 23: 8-13.
30. Carpenter, J.L., Holzworth, J. Thymoma in 11 cats. Journal of American Veterinary Medical Association 1982; 181: 248-51.
31. Loveday, R.K. Thymoma in a Siamese cat. Journal of the South African Veterinary Medical Association 1959; 30: 33-4.
32. Forster-Van Hijfte, M.A., Curtis, C.F., White, R.N. Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. Journal of Small Animal Practice 1997; 38: 451-4.
33. Boyce, S., Harper, J. Paraneoplastic dermatoses. Dermatology Clinics 2002; 20: 523-32.
34. Godfrey, D.R. Dermatosis and associated systemic signs in a cat with thymoma and recently treated with an imidacloprid preparation. Journal of Small Animal Practice 1999; 40: 333-7.
35. Withrow, S.J. Thymoma. In: Withrow, S.J., MacEwen, E.G., eds. Small Animal Clinical Oncology, 3rd edn. W.B. Saunders, Philadelphia, 2001: 646-51.
36. Suter, M., Lott-Stolz, G., Wild, P. Generalized nodular dermatofibrosis in six Alsatians. Veterinary Pathology 1983; 20: 632-4.
37. Lium, B., Moe, L. Hereditary multifocal renal cystadenocarcinomas and nodular dermatofibrosis in the German shepherd dog: macroscopic and histologic changes. Veterinary Pathology 1985; 22: 447-55.
38. Cosenza, S.F., Seely, J.C. Generalized nodular dermatofibrosis and renal cystadenocarcinomas in a German shepherd dog. Journal of American Medical Association 1986; 189: 1587-90.
39. Gilbert, P.A., Griffin, C.E., Walder, E.J. Nodular dermatofibrosis and renal cystadenoma in a German shepherd dog. Journal of American Animal Hospital Association 1990; 26: 253-6.
40. Atlee, B.A., DeBoer, D.J., Ihrke, P.J. et al. Nodular dermatofibrosis in German shepherd dogs as a marker for renal cystadenocarcinoma. Journal of American Animal Hospital Association 1991; 27: 481-7.
41. Moe, L., Lium, B. Hereditary multifocal renal cystadenocarcinomas and nodular dermatofibrosis in 51 German shepherd dogs. Journal of Small Animal Practice 1997; 38: 498-505.
42. Jónasdóttir, T.J., Mellersh, C.S., Moe, L. et al. Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs. Proceeding of the National Academy of Science of the USA 2000; 97 (8): 4132-7.
43. Marks, S.L., Farman, C.A., Peaston, A. Nodular dermatofibrosis and renal cystadenomas in a golden retriever. Veterinary Dermatology 1994; 4: 133-7.
44. Moe, L., Gamlem, H., Jónasdóttir, T.J. et al. Renal microscopic tubular lesions in two 1-year-old dogs - an early sign of hereditary renal cystadenocarcinoma? Journal of Comparative Pathology 2000; 123: 218-21.
45. Hayes, H.M. Jr., Pendergrass, T.W. Canine testicular tumors: epidemiologic features of 410 dogs. International Journal of Cancer 1976; 18: 482-7.
46. Reif, J.S., Brodey, R.S. The relationship between cryptorchidism and canine testicular neoplasia. Journal of the American Veterinary Medical Association 1969; 155 (12): 2005-10.
47. Cooley, D.M., Waters, D.J. Tumors of the male reproductive system. In: Withrow, S.J., MacEwen, E.G., eds. Small Animal Clinical Oncology, 3rd edn. WB. Saunders, Philadelphia, 2001, 478-89.
48. Lipowitz, A.J., Schwartz, A., Wilson, G.P. et al. Testicular neoplasms and concomitant clinical changes in the dog. Journal of the American Veterinary Medical Association 1973; 163 (12): 1364-8.
49. Weaver, A.D. Survey with follow-up of 67 dogs with testicular Sertoli cell tumours. Veterinary Record 1983; 113: 105-7.
50. Morgan, R.V. Blood dyscrasias associated with testicular tumors in the dog. Journal of the American Animal Hospital Association 1982; 18: 970-5.
51. Suess, R.P. Jr., Barr, S.C., Sacre, B.J. et al. Bone marrow hypoplasia in a feminized dog with an interstitial cell tumor. Journal of the American Animal Hospital Association 1992; 200 (9): 1346-8.
52. Peters, M.A.J., de Jong, F.H., Teerds, K.J. et al. Ageing, testicular tumours and the pituitary-testis axis in dogs. Journal of Endocrinology 2000; 166: 153-61.
53. Peters, M.A.J., Teerds, K.J., van der Gaag, I. et al. Use of antibodies against LH receptor, 3β-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs. Reproduction 2001; 121: 287-96.
54. Sanpera, N., Masot, N., Janer, M. et al. Oestrogen-induced bone marrow aplasia in a dog with a Sertoli cell tumour. Journal of Small Animal Practice 2002; 43: 365-9.
55. Fadok, V.A., Lothrop, C.D. Jr., Coulson, P. Hyperprogesteronemia associated with Sertoli cell tumor and alopecia in a dog. Journal of the American Veterinary Medical Association 1986; 188 (9): 1058-9.
56. Edwards, D.F. Bone marrow hypoplasia in a feminized dog with a Sertoli cell tumor. Journal of the American Veterinary Medical Association 1981; 178 (5): 494-6.
57. Lindberg, R., Jonsson, O.-J., Kasström, H. Sertoli cell tumours associated with feminization, prostatitis and squamous metaplasia of the renal tubular epithelium in a dog. Journal of Small Animal Practice 1976; 17: 451-8.
58. Sherding, R.G., Wilson, G.P., Kociba, G.J. Bone marrow hypoplasia in eight dogs with Sertoli cell tumor. Journal of the American Veterinary Medical Association 1981; 178 (5): 497-501.
59. Kawakami, E., Hori, T., Tsutsui, T. Relationship between testicular transferrin and plasma estradiol-17β concentrations of dogs with azoospermia and dogs with Sertoli cell tumors. Journal of Veterinary Medical Science 2001; 63 (5): 579-81.
60. Comhaire, F., Mattheeuws, D., Vermeulen, A. Testosterone and oestradiol in dogs with testicular tumours. Acta Endocrinologica 1974; 77: 408-16.
61. Siegel, E.T., Forchielli, E., Dorfman, R.I. et al. An estrogen study in the feminized dog with testicular neoplasia. Endocrinology 1967; 80: 272-7.
62. Pierrepoint, C.G. The metabolism in vitro of dehydroepiandrosterone and dehydroepiandrosterone sulfate by Sertoli cell tumors of the testis of two dogs with clinical signs of hyperestrogenism. Journal of Endocrinology 1968; 42: 99-107.
63. Mischke, R., Meurer, D., Hoppen, H.-O. et al. Blood plasma concentrations of oestradiol-17β, testosterone and testosterone/oestradiol ratio in dogs with neoplastic and degenerative testicular diseases. Research in Veterinary Science 2002; 73: 267-72.
64. Wermers, R.A., Fatourechi, V., Wynne, A.G. et al. The glucagonoma syndrome: clinical and pathologic features in 21 patients. Medicine 1996; 75 (2): 53-63.
65. Kasper, C.S. Necrolytic migratory erythema. Unresolved problems in diagnosis and pathogenesis. A case report and literature review. Cutis 1992; 49: 120-8.
66. Doyle, J.A., Schroeter, A.L., Rogers, R.S. III. Hyperglucagonaemia and necrolytic migratory erythema in cirrhosis - possible pseudoglucagonoma syndrome. British Journal of Dermatology 1979; 100: 581-7.
67. Kasper, C.S., McMurry, K. Necrolytic migratory erythema without glucagonoma versus canine superficial necrolytic dermatitis: is hepatic impairment a clue to pathogenesis? Journal of the American Academy of Dermatology 1991; 25: 534-41.
68. Marinkovich, M.P., Botella, R., Datloff, J. et al. Necrolytic migratory erythema without glucagonoma in patients with liver disease. Journal of the American Academy of Dermatology 1995; 32: 604-9.
69. Byrne, K.P. Metabolic epidermal necrosis-hepatocutaneous syndrome. Veterinary Clinics of North America: Small Animal Practice 1999; 29 (6): 1337-55.
70. Gross, T.L., O'Brien, T.D., Davies, A.P. et al. Glucagon-producing pancreatic endocrine tumors in two dogs with superficial necrolytic dermatitis. Journal of American Veterinary Medical Association 1990; 197: 1619-22.
71. Miller, W.H. Jr., Anderson, W.I., McCann, J.P. Necrolytic migratory erythema in a dog with a glucagon-secreting endocrine tumor. Veterinary Dermatology 1991; 2: 179-82.
72. Bond, R., McNeil, P.E., Evans, H. et al. Metabolic epidermal necrosis in two dogs with different underlying diseases. Veterinary Record 1995; 136: 466-71.
73. Torres, S.M.F., Caywood, D.D., O'Brien, T.D. et al. Resolution of superficial necrolytic dermatitis following excision of a glucagon-secreting pancreatic neoplasm in a dog. Journal of American Animal Hospital Association 1997; 33: 313-19.
74. Torres, S., Johnson, K., McKeever, P. et al. Superficial necrolytic dermatitis and a pancreatic endocrine tumor in a dog. Journal of Small Animal Practice 1997; 38: 246-50.
75. Allenspach, K., Arnold, P., Glaus, T. et al. Glucagon-producing neuroendocrine tumour associated with hypoaminoacidaemia and skin lesions. Journal of Small Animal Practice 2000; 41: 402-6.
76. Patel, A., Whitbread, T.J., McNeil, P.E. A case of metabolic epidermal necrosis in a cat. Veterinary Dermatology 1996; 7: 221-6.
77. Miller, W.H., Scott, D.W., Buerger, R.G. et al. Necrolytic migratory erythema in dogs: a hepatocutaneous syndrome. Journal of American Animal Hospital Association 1990; 26: 573-81.
78. Outerbridge, C.A., Marks, S.L., Rogers, Q.R. Plasma amino acid concentrations in 36 dogs with histologically confirmed superficial necrolytic dermatitis. Veterinary Dermatology 2002; 13: 177-86.
79. Gross, T.L., Ihrke, P.J. Necrotizing diseases of the epidermis (superficial necrolytic dermatitis). In: Gross, T.L., Ihrke, P.J., Walder, E.J., eds. Veterinary Dermatopathology: A Macroscopic and Microscopic Evaluation of Canine and Feline Skin Disease. Mosby Year Book, St. Louis, MO, 1992, 46-8.
80. Gross, T.L., Song, M.D., Havel, P.J. et al. Superficial necrolytic dermatitis (necrolytic migratory erythema) in dogs. Veterinary Pathology 1993; 30: 75-81.
81. Nyland, T.G., Mattoon, J.S., Herrgesell, E.J. et al. Pancreas. In: Nyland, T.G., Mattoon, J.S., eds. Small Animal Diagnostic Ultrasound, 2nd edn. WB. Saunders, Philadelphia, 2002: 144-57.
82. Cartee, R.E., Selcer, B.A., Hudson, J.A. et al. Practical Veterinary Ultrasound. Williams & Wilkins, Philadelphia, 1995, 52-9.
83. Norton, J.A., Kahn, C.R., Schiebinger, R. et al. Amino acid deficiency and the skin rash associated with glucagonoma. Annals of Internal Medicine 1979; 91: 213-15.
84. Shepherd, M.E., Raimer, S.S., Tyring, S.K. et al. Treatment of necrolytic migratory erythema in glucagonoma syndrome. Journal of the American Academy of Dermatology 1991; 25: 925-28.
85. Walton, D.K., Center, S.A., Scott, D.W. et al. Ulcerative dermatitis associated with diabetes mellitus in the dog: a report of four cases. Journal of American Animal Hospital Association 1986; 22: 79-88.
86. Rosenbaum, A., Flourie, B., Chagnon, S. et al. Octreotide (SMS 201-995) in the treatment of metastatic glucagonoma: report of one case and review of the literature. Digestion 1989; 42: 116-20.
87. Nguyen, V.T., Ndoye, A., Bassler, D.D. et al. Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome. Archives of Dermatologica 2001; 137: 193-206.
88. Lemmens, P., de Bruin, A., de Meulemeester, J. et al. Paraneoplastic pemphigus in a dog. Veterinary Dermatology 1998; 9: 127-34.
89. de Bruin, A., Muller, E., Wyder, M. et al. Periplakin and envoplakin are target antigens in canine and human paraneoplastic pemphigus. Journal of the American Academy of Dermatology 1999; 40: 682-5.
90. Allen, C.M., Camisa, C. Paraneoplastic pemphigus: a review of the literature. Oral Diseases 2000; 6: 208-14.
91. Horn, T.D., Anhalt, G.J. Histologic features of paraneoplastic pemphigus. Archives of Dermatology 1992; 128: 1091-5.
92. Gross, T.L., Ihrke, P.J. Bullous and vesicular diseases of the epidermis and dermal-epidermal junction (pemphigus vulgaris). In: Gross, T.L., Ihrke, P.J., Walder, E.J., eds. Veterinary Dermatopathology: A Macroscopic and Microscopic Evaluation of Canine and Feline Skin Disease. Mosby Year Book, St. Louis, 1992: 31-4.
93. Hashimoto, T., Amagai, M., Watanabe, K. et al. Characterization of paraneoplastic pemphigus autoantigens by immunoblot analysis. Journal of Investigative Dermatology 1995; 104: 829-34.
94. Kiyodawa, C. Envoplakin and periplakin are the paraneoplastic pemphigus antigens. Kurume Medical Journal 1999; 46: 71-8.
95. Lee, M., Kossard, S., Ho, K.K.L. et al. Paraneoplastic pemphigus triggered by radiotherapy. Australian Journal of Dermatology 1995; 36: 206-10.
96. Fried, R., Lynfield, Y., Vitale, P. et al. Paraneoplastic pemphigus appearing as bullous pemphigoid-like eruption after palliative radiation therapy. Journal of the American Academy of Dermatology 1995; 29: 815-17.
97. Williams, M.A., Dowling, P.M., Angarano, D.W. et al. Paraneoplastic bullous stomatitis in a horse. Journal of the American Veterinary Medical Association 1995; 207: 331-4.
98. Finley, M.R., Rebhun, W.C., Dee, A. et al. Paraneoplastic pruritus and alopecia in a horse with diffuse lymphoma. Journal of the American Veterinary Medical Association 1998; 213: 102-4.
99. Schwartzman, R.M. Cutaneous amyloidosis associated with a monoclonal gammopathy in a dog. Journal of the American Veterinary Medical Association 1984; 185: 102-4.
100. Ashley, P.F., Bowman, L.A. Symmetric cutaneous necrosis of the hind feet and multicentric follicular lymphoma in a cat. Journal of the American Veterinary Medical Association 1999; 214: 211-14.
101. Miller, WH. Cutaneous flushing associated with intrathoracic neoplasia in a dog. Journal of the American Animal Hospital Association 1992; 28: 217-19.