Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes

Journal of Clinical Pharmacy and Therapeutics

Volumn 28, Issue 6, 2003, Pages 493-496

  Tanaka, Einosuke ^a   Kurata, N ^b   Yasuhara, H ^b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

B lymphoblast cells; Baculovirus infected insect cells; Cytochrome P450; Human liver microsomes; Inhibitor; Trimethadione

Indexed keywords

ANTICONVULSIVE AGENT; COMPLEMENTARY DNA; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; RECOMBINANT ENZYME; TRIMETHADIONE;

ANIMAL CELL; ARTICLE; B LYMPHOBLAST; BACULOVIRUS; CONTROLLED STUDY; DEMETHYLATION; DRUG OXIDATION; ENZYME ACTIVITY; EXPERIMENTAL INFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSECT CELL; LIVER FUNCTION; LIVER METABOLISM; LIVER MICROSOME; NONHUMAN; PROTEIN EXPRESSION; VIRUS INFECTION;

ANTICONVULSANTS; ARYL HYDROCARBON HYDROXYLASES; BACULOVIRIDAE; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MICROSOMES, LIVER; TRIMETHADIONE;

EID: 0346962900     PISSN: 02694727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2710.2003.00524.x     Document Type: Article

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