Pancreas Graft Thrombosis: Is There a Role for Trypsin

Pancreas

Volumn 28, Issue 1, 2004, Pages 75-79

  Benz, Stefan ^a,e   Busing, M ^b   Kruger, B ^c   Mayer, J M ^d   Obermaier, R ^a   Keck, T ^a   Pfeffer, F ^a   Hopt, U T ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Chirurgische Klinik Recklinghausen   (Germany)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d UNIVERSITY OF ULM   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Graft pancreatitis; Graft thrombosis; Ischemia; Pancreas transplantation; Proteases; Trypsin

Indexed keywords

ANTIPLASMIN; ANTITHROMBIN III; IMMUNOSUPPRESSIVE AGENT; PLASMIN; PREDNISOLONE; PROTEIN C; THROMBIN ANTITHROMBIN COMPLEX; TRYPSIN; TRYPSINOGEN;

ADULT; ARTICLE; BLOOD CLOTTING PARAMETERS; BLOOD SAMPLING; CADAVER DONOR; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; GRAFT REJECTION; HUMAN; HYPERCOAGULABILITY; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY ALLOGRAFT; KIDNEY FAILURE; ORGAN TRANSPLANTATION; PANCREAS TRANSPLANTATION; PANCREATITIS; PRIORITY JOURNAL; RADIAL ARTERY; SPLENIC VEIN; THROMBOSIS;

ANTIPLASMIN; ANTITHROMBINS; BLOOD COAGULATION; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; OLIGOPEPTIDES; PANCREAS; PANCREAS TRANSPLANTATION; PLASMIN; POSTOPERATIVE COMPLICATIONS; PROTEIN C; THROMBIN; THROMBOSIS; TIME FACTORS; TRYPSIN; TRYPSINOGEN;

EID: 0346787896     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200401000-00012     Document Type: Article

References (15)

1. Tyden G, Bolinder J, Solders G, et al, Improved survival in patients with insulin-dependent diabetes mellitus and end-stage diabetic nephropathy 10 years after combined pancreas and kidney transplantation. Transplantation. 1999;67:645-648.
2. Gruessner AC, Sutherland DE. Analysis of United States (US) and non-US pancreas transplants reported to the United network for organ sharing (UNOS) and the international pancreas transplant registry (IPTR) as of October 2001. Clin Transpl. 2001:41-72.
3. Nader A, Busing M, Blumenstock I, et al. Coagulation disorders after reperfusion of pancreatic allografts. Transplant Proc. 1993;25:1174-1175.
4. Benz S, Obermaier R, Pfeffer F, et al. Impairment of microcirculation in the early reperfusion period correlates with the degree of graft pancreatitis in simultaneous pancreas-/kidney transplantation. Transplantation. 2001;71:759-763.
5. Brigden ML The hypercoagulable state. Who, how, and when to test and treat. Postgrad Med. 1997;101:249-252, 254-246, 259-262 passim.
6. Nizzi FA Jr, Kaplan HS. Protein C and S deficiency. Semin Thromb Hemost. 1999;25:265-272.
7. Ottesen LH, Bladbjerg EM, Osman M, et al. Protein C activation during the initial phase of experimental acute pancreatitis in the rabbit. Dig Surg. 1999;16:486-495.
8. Petaja J, Pesonen E, Fernandez JA, Vento AE, Ramo OJ, Griffin JH. Cardiopulmonary bypass and activation of antithrombotic plasma protein C. J Thorac Cardiovasc Surg. 1999;118:422-429; discussion 429-431.
9. Ilmakunnas M, Petaja J, Hockerstedt K, et al. Activation of protein C during reperfusion in clinical liver transplantation. Transplantation. 2003;75:467-472.
10. Busing M, Hopt UT, Jochum M, et al. Characterization of early graft damage after pancreatic transplantation. Transplant Proc. 1992;24:811-812.
11. Kallen R, Montgomery A, Borgstrom A. Protease activation following reperfusion of porcine pancreatic allografts. J Surg Res. 1992;53:495-501.
12. Lasson A, Laurell AB, Ohlsson K. Correlation among complement activation, protease inhibitors, and clinical course in acute pancreatitis in man. Scand J Gastroenterol. 1985;20:335-345.
13. Ohlsson K, Olsson R, Bjork P, et al. Local administration of human pancreatic secretory trypsin inhibitor prevents the development of experimental acute pancreatitis in rats and dogs. Scand J Gastroenterol. 1989;24:693-704.
14. Bleeker WK, Agterberg J, Rigter G, et al. Protective effect of antithrombin iii in acute experimental pancreatitis in rats. Dig Dis Sci. 1992;37:280-285.
15. Inthorn D, Hoffmann JN, Hartl WH, et al. Effect of antithrombin III supplementation on inflammatory response in patients with severe sepsis. Shock. 1998;10:90-96.