The effect of hydrophobic character of drugs and 2 helix-coil transition of κ-carrageenan on the polyelectrolyte-drug interaction

Pharmaceutical Research

Volumn 13, Issue 6, 1996, Pages 920-925

  Caram Lelham, Ninus ^a   Sundelöf, Lars Olof ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

carrageenan; Amphiphile polyelectrolyte interaction; Charge to charge interaction; Drug adsorption; Helix coil transition; Hydrophobic interaction

Indexed keywords

AMITRIPTYLINE; CARRAGEENAN; CHLORPROMAZINE; CLOMIPRAMINE; DOXEPIN; IMIPRAMINE; POLYELECTROLYTE; POLYMER;

ARTICLE; CHEMICAL STRUCTURE; DRUG ADSORPTION; ELECTRICITY; HYDROPHOBICITY; MICELLE; PRIORITY JOURNAL; SOLUBILIZATION; SPECTROPHOTOMETRY;

ADSORPTION; CARRAGEENAN; CHEMISTRY, PHYSICAL; DIALYSIS; MOLECULAR CONFORMATION; PHARMACEUTIC AIDS; PHARMACEUTICAL PREPARATIONS; SPECTROPHOTOMETRY; THERMODYNAMICS;

EID: 0029996759     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016017515366     Document Type: Article

References (15)

1. A. T. Florence and D. Attwood. Physicochemical principles of pharmacy. (Second ed.) Macmillan, London, 1992.
2. E. D. Goddard. Polymer-surfactant interaction Part II. Polymer and surfactant of opposite charge. Colloids and Surfaces. 19:301-329 (1986).
3. N. Caram-Lelham and L.-O. Sundelöf. Changes in the polyelectrolyte-amphiphile interaction due to helix-coil transition induced by specific counterions or variations in temperature. Accepted for publication in Biopolymers.
4. N. Caram-Lelham and L.-O. Sundelöf. Some aspects on characterization and properties of charged polysaccharides. An investigation of the system carrageenan/amitriptyline/water with relation to amphiphile adsorption and charge density. Int. J. Pharm. 115:103-111 (1995).
5. N. Caram-Lelham, R. L. Cleland, and L.-O. Sundelöf. Temperature and salt optimization of κ-carrageenan fractionation by DEAE-cellulose. Int. J. Biol. Macromol. 16:71-75 (1994).
6. Y. Li, P. L. Dubin, H. A. Havel, S. L. Edwards, and H. Dautzenberg. Electrophoretic light scattering, dynamic light scattering, and turbidimetry studies of the effect of polymer concentration on complex formation between polyelectrolyte and oppositely charged mixed micelles. Macromolecules. 28:3098-3102 (1995).
7. K. Hayakawa, J. P. Santerre, and J. C. T. Kwak. Study of surfactant-polyelectrolyte interactions. Binding of dodecyl- and tetrade-cyltrimethylammonium bromide by some carboxylic polyelectrolytes. Macromolecules. 16:1642-1645 (1983).
8. A. Malovikova, K. Hayakawa, and J. C. T. Kwak. Surfactant-polyelectrolyte interactions. 4. Surfactant chain length dependence of the binding of alkylpyridinium cations to dextran sulfates. J. Phys. Chem. 88:1930-1933 (1983).
9. K. Hayakawa and J. C. T. Kwak. Surfactant-polyelectrolyte inter-actions. 1. Binding of dodecyltrimethylammonium ions by sodium dextran sulfate and sodium poly(styrenesulfonate) in aqueous solution in the presence of sodium chloride. J. Phys. Chem. 86:3866-3870 (1982).
10. A. C. Moffat. Clarke's isolation and identification of drugs. (Second ed.) The Pharmaceutical Press, London, 1986.
11. D. Attwood and J. Gibson. Aggregation of antidepressant drugs in aqueous solution. J. Pharm. Pharmac. 30:176-180 (1978).
12. D. Attwood and R. Natarajan. Miceliar properties of chlorpromazine hydrochloride in concentrated electrolyte solutions. J. Pharm. Pharmacol. 35:317-319 (1983).
13. C. Rochas and M. Rinaudo. Activity coefficients of counterions and conformation in kappa-carrageenan systems. Biopolymers 19:1675-1687 (1980).
14. T. H. M. Snoeren and T. A. J. Payens. On the sol-gel transition in solutions of kappa-carrageenan. Biochim. Biophys. Acta 437:264-272 (1976).
15. B. J. Kvam and H. Grasdalen. Probe for the conformational transition of carrageenans. Effect of Mn2+-induced 1H NMR relaxation of tetramethylammonium ions in aqueous tetramethylammonium carrageenate solutions. Macromolecules 22:3919-3928 (1989).