Autoimmune Response in Mothers of Children with Congenital and Postnatally Diagnosed Isolated Heart Block: A Population Based Study

Journal of Rheumatology

Volumn 31, Issue 1, 2004, Pages 183-189

  Julkunen, Heikki ^a   Miettinen, Aaro ^b   Walle, Timo K ^b   Chan, Edward K L ^c   Eronen, Marianne ^d  

^a PEIJAS HOSPITAL   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Antibodies; Congenital heart block; Neonatal lupus; SSA; SSB

Indexed keywords

DNA ANTIBODY; DOUBLE STRANDED DNA; HISTONE; IMMUNOGLOBULIN; MATERNAL ANTIBODY; PROTEIN SSA; PROTEIN SSB; SJOGREN SYNDROME ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; CONGENITAL HEART BLOCK; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; FINLAND; HEART BLOCK; HUMAN; IMMUNOASSAY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; INFANT; MAJOR CLINICAL STUDY; MATERNAL DISEASE; MEDICAL RECORD; NEWBORN; PERINATAL PERIOD; POPULATION RISK; PRIORITY JOURNAL; RISK ASSESSMENT; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; TIME RESOLVED FLUOROIMMUNOASSAY;

ADULT; ANTIBODIES, ANTINUCLEAR; BIOLOGICAL MARKERS; CHILD; FEMALE; HEART BLOCK; HUMANS; INFANT, NEWBORN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; MOTHERS; PREDICTIVE VALUE OF TESTS; REGISTRIES; RISK FACTORS; SEROEPIDEMIOLOGIC STUDIES;

EID: 0346688673     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Buyon JP, Kim MY, Copel JA, Friedman DM. Anti-Ro/SSA antibodies and congenital heart block: necessary but not sufficient. Arthritis Rheum 2001;44:1723-7.
2. Allan L, Hornberger L, Sharland G. Fetal cardiac tumors. In: Allan L, Hornberger L, Sharland G, editors. Textbook of fetal cardiology. London: Greenwich Medical Media Limited; 2000:358-65.
3. Hubscher O, Batista N, Rivero S, et al. Clinical and serological identification of 2 forms of complete heart block in children. J Rheumatol 1995;22:1352-5.
4. McCarron DP, Hellman DB, Traill TA, Watson RM. Neonatal lupus erythematosus syndrome: late detection of isolated heart block. J Rheumatol 1993;20:1212-4.
5. Geggel RL, Tucker L, Szer I. Postnatal progression from second- to third-degree heart block in neonatal lupus erythematosus syndrome. J Pediatrics 1998;113:1049-52.
6. Waltuck J, Buyon JP. Auto-antibody-associated congenital heart block: outcome of mothers and children. Ann Intern Med 1994;120:544-51.
7. Press J, Uziel Y, Laxer RM, Luy L, Hamilton RM, Silverman ED. Long-term outcome of mothers of children with congenital heart block. Am J Med 1996;100:328-32.
8. Julkunen H, Eronen M. Long-term outcome of mothers of children with isolated heart block in Finland. Arthritis Rheum 2001;44:647-52.
9. Nolan RJ, Shulman ST, Victorica BE. Congenital complete heart block associated with maternal mixed connective tissue disease. J Pediatr 1979;95:420-2.
10. Brucato A, Frassi M, Franceschini M, et al. Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women. Arthritis Rheum 2001;44:1832-5.
11. Buyon JP, Winchester RJ, Slade SG, et al. Identification of mothers at risk for congenital HB and other neonatal lupus syndromes in their children. Arthritis Rheum 1993;36:1263-73.
12. Julkunen H, Kaaja R, Siren MK, et al. Immune-mediated congenital heart block (CHB): Counseling pregnancies and identifying risk factors for CHB. Semin Arthritis Rheum 1998;28:97-106.
13. Buyon JP, Hiebert R, Copel J, et al. Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol 1998;31:1658-66.
14. Julkunen H, Eronen M. Rate of recurrence of congenital heart block - a population based study. Arthritis Rheum 2001;44:487-8.
15. Eronen M, Siren MK, Ekblad H, Tikanoja T, Julkunen H, Paavilainen T. Short and long-term outcome of the children with isolated congenital complete heart block diagnosed in utero or as newborn. Pediatrics 2000;106:86-91.
16. Julkunen H, Kurki P, Kaaja R, et al. Isolated congenital heart block: long-term outcome of mothers and characterization of the immune response to SSA/Ro and SSB/La. Arthritis Rheum 1993;36:1488-98.
17. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
18. Vitali C, Bombardieri S, Moutsopoulos HM, et al. Preliminary criteria for the classification of Sjögren's syndrome. Results of an EEC prospective concerted action. Arthritis Rheum 1993;36:340-7.
19. Alarcon-Segovia D, Cardiel MM. Comparison between three diagnostic criteria for mixed connective disease. Study of 593 patients. J Rheumatol 1989;16:328-34.
20. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980;23:581-90.
21. Bohan A, Peter JB. Polymyositis and dermatomyositis. Part I and part II. N Engl J Med 1975;292:344-7,403-7.
22. Chan EKL, Sullivan KF, Tan EM. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for DNA-binding. Nucl Acid Res 1989;17:2233-44.
23. Chan EKL, Hamel JC, Buyon JP, Tan EM. Molecular definition and sequence motifs of the 52-kd component of human SS-A/Ro autoantigen. J Clin Invest 1991;87:68-76.
24. Fritzler MJ, Hanson C, Miller J, Eystathioy T. Specificity of autoantibodies to SS-A/Ro on a transfected and overexpressed human 60 kDa Ro autoantigen substrate. J Clin Lab Anal 2002;16:103-8.
25. Keech CL, Howarth S, Coates T, Rischmueller M, McCluskey J, Gordon TP. Rapid and sensitive detection of anti-Ro (SS-A) antibodies by indirect immunofluorescence of 60kDa Ro HEp-2 transfectants. Pathology 1996;28:54-7.
26. Arnett FC, Bias WB, Reveille JD. Genetic studies in Sjögren's syndrome and systemic lupus erythematosus. J Autoimmun 1989;2:403-13.
27. Tseng CE, Di Donato F, Buyon JP. Stability of immunoblot profile of anti-SSA/Ro-SSB/La antibodies over time in mothers whose children have neonatal lupus. Lupus 1996;5:212-5.
28. Yamagata H, Akizuki M, Tojo T, Homma M. Anti-Ro/SSA and -La/SSB antibodies in patients with connective tissue diseases. Scand J Rheumatol 1986;15 Suppl:98-101.
29. Brucato A, Franceschini F, Gasparini M, et al. Isolated congenital HB: Long-term outcome of mothers, maternal antibody specificity and immunogenetic background. J Rheumatol 1995;22:533-40.
30. Scott JS, Maddison PJ, Taylor PV, Essher E, Scott O, Skinner P. Connective tissue disease, antibodies to ribonucleoprotein and congenital heart block. N Engl J Med 1983;309:209-12.
31. Bharati S, Lev M. Pathology of atrioventricular block. Cardiovasc Clin 1984;2:741-51.
32. Waterman SA, Gordon TP, Rischmueller M. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjögren's syndrome. Arthritis Rheum 2000;43:1647-54.
33. Eftekhari P, Salle L, Lezoualch F, et al. Anti-SSA/Ro52 autoantibodies blocking the cardiac 5-HT4 serotoninergic receptor could explain neonatal lupus congenital heart block. Eur J Immunol 2000;30:2782-90.
34. Buyon JP. Neonatal lupus syndrome. In: Lahita R, editor. Systemic lupus erythematosus. 3rd ed. New York: Academic Press; 1998:337-59.