Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol

Journal of Biological Chemistry

Volumn 277, Issue 47, 2002, Pages 45219-45225

  Avvakumov, George V ^a   Grishkovskaya, Irina ^b   Muller, Yves A ^b,c   Hammond, Geoffrey L ^a,d  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

^d LONDON REGIONAL CANCER PROGRAM   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CRYSTAL STRUCTURE; HORMONES; HYDROGEN BONDS; METABOLITES; PROTEINS; REACTION KINETICS; ZINC;

GLOBULIN;

BIOCHEMISTRY;

2 METHOXYESTRADIOL; ESTRADIOL DERIVATIVE; ESTROGEN; LIGAND; SEX HORMONE BINDING GLOBULIN; ZINC;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; HORMONE PROTEIN COMPLEX; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HUMAN; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN INTERACTION;

ALANINE; ASPARAGINE; ASPARTIC ACID; BINDING SITES; DIHYDROTESTOSTERONE; ESTRADIOL; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEX HORMONE-BINDING GLOBULIN; ZINC;

EID: 0346668365     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207762200     Document Type: Article

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